A5031689588- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Parasite Biology and Host Interactions
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parasites and Host Interactions
- Coccidia and coccidiosis research
- Vector-borne infectious diseases
- Yersinia bacterium, plague, ectoparasites research
- Heme Oxygenase-1 and Carbon Monoxide
- Dermatological diseases and infestations
- Vector-Borne Animal Diseases
- Mollusks and Parasites Studies
- Legionella and Acanthamoeba research
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Rabies epidemiology and control
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Bird parasitology and diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mycobacterium research and diagnosis
- Insect and Pesticide Research
- Insects and Parasite Interactions
University of Nottingham
2016-2025
Loughborough University
2009-2025
University of Liège
2022
Gansu Agricultural University
2020
Jilin Agricultural University
2020
Lanzhou Veterinary Research Institute
2017-2020
Chinese Academy of Agricultural Sciences
2017-2020
Yangzhou University
2020
Nottingham College
2007-2017
Sutton Hospital
2014
Abstract Sexual development in Toxoplasma gondii is a multistep process that culminates the production of oocysts, constituting approximately 50% human infections. However, molecular mechanisms governing sexual commitment this parasite remain poorly understood. Here, we demonstrate transcription factors AP2XI-2 and AP2XII-1 act as negative regulators, suppressing merozoite-primed pre-sexual during asexual development. Depletion type II Pru strain induces merogony mature merozoites an...
Haemoproteus and Plasmodium species are widespread avian blood parasites. Several known for their high virulence have caused significant declines in naïve bird populations. The impact of closely related parasites is largely unknown. Recently we reported a lethal disease two parrot aviaries by Here show that the causative pathogen minutus responsible further 17 outbreaks Denmark, Germany Great Britain. All affected parrots endemic to Australasia South America. We sequenced cytochrome b gene...
Phenotypic switching between tachyzoite and bradyzoite is the fundamental mechanism underpinning pathogenicity adaptability of protozoan parasite Toxoplasma gondii. Although accumulation cytoplasmic starch granules a hallmark quiescent stage, regulatory factors mechanisms contributing to amylopectin storage in bradyzoites are incompletely known. Here, we show that T. gondii protein phosphatase 2A (PP2A) holoenzyme composed catalytic subunit PP2A-C, scaffold PP2A-A PP2A-B. Disruption any...
Campylobacter jejuni is a globally distributed cause of human food-borne enteritis and has been linked to chronic joint neurological diseases. We hypothesized that C. 11168 colonizes the gastrointestinal tract both C57BL/6 mice congenic interleukin-10-deficient (IL-10(-/-)) IL-10(-/-) experience 11168-mediated clinical signs pathology. Individually housed were challenged orally with 11168, course infection was monitored by examination, bacterial culture, jejuni-specific PCR, gross pathology,...
Toxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order maintain its survival. This parasite can modulate signaling pathways of through secretion polymorphic effector proteins localized rhoptry and dense granule organelles. One such effectors is T. gondii type II-specific protein 15, TgGRA15, which activates NF-κB pathway. The aim present study was identify interaction partner TgGRA15. We screened a yeast...
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, human and murine STAT2-deficient phenotypes suggest important additional currently unidentified IFN-independent activities. Here, we show that constitutively bound to STAT1, but not STAT3, via conserved interface. While this interaction was irrelevant interferon signaling STAT1 activation, precluded nuclear translocation specifically of in response IFN-γ,...
Abstract Background The cysteine proteinases in papaya latex have been shown to potent anthelmintic properties monogastric hosts such as rodents, pigs and humans, but this has not demonstrated ruminants. Methods In two experiments, sheep were infected concurrently with 5,000 infective larvae of Haemonchus contortus 10,000 Trichostrongylus colubriformis then treated the supernatant from a suspension day 28 32 post-infection. Faecal egg counts monitored week before treatment until end...
Abstract Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim this study was investigate dynamic in metabolic profile mouse sera during T. gondii infection. We carried out untargeted metabolomic analysis collected from female BALB/c mice experimentally infected Pru strain (Genotype II). Serum samples were at 7, 14 21 day post infection (DPI) control subjected liquid...
Toxoplasmosis remains a world-threatening disease largely because of the lack fully effective vaccine. Here, we created ΔGRA17 mutant by disrupting virulence factor GRA17 using CRISPR-Cas9 method. Then, tested whether tachyzoites can be used as live-attenuated vaccine against acute, chronic, and congenital Toxoplasma gondii infection in mice. Immune response evoked immunization suggested sequential Th1 Th2 T cell response, indicated high levels mixed Th1/Th2 cytokines at 28 70 days after...
Toxoplasma gondii remains a global public health problem. However, its pathophysiology is still not-completely understood particularly the impact of infection on host liver metabolism. We performed iTRAQ-based proteomic analysis to evaluate early protein responses in BALB/c mice following with T. PYS strain (genotype ToxoDB#9) infection. Our data revealed modification expression key metabolic pathways, as indicated by upregulation immune response and downregulation mitochondrial respiratory...