A5100744585- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Tissue Engineering and Regenerative Medicine
- Glycosylation and Glycoproteins Research
- Healthcare and Venom Research
- Inflammatory mediators and NSAID effects
- Mesenchymal stem cell research
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Transplantation: Methods and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Advanced Electron Microscopy Techniques and Applications
- Kruppel-like factors research
- Medical Research and Treatments
Beijing Children’s Hospital
2021-2025
Capital Medical University
2021-2025
Second Military Medical University
2009-2025
Changhai Hospital
2015-2025
Center for Children
2025
Shandong University of Traditional Chinese Medicine
2024
Zhongshan Hospital
2024
Fudan University
2024
Southwest Hospital
2023
Army Medical University
2023
Cancer stem cells (CSCs), also known as tumor-initiating (TICs), contribute to tumorigenesis, resistance chemoradiotherapy and recurrence in human cancers, suggesting targeting CSCs may represent a potential therapeutic strategy. In the current study, we found family with sequence similarity 83, member A (FAM83A) is significantly overexpressed associated poorer overall survival disease-free pancreatic cancer. Overexpression of FAM83A markedly promoted, whereas inhibition decreased, CSC-like...
This study aimed to determine the global distribution and molecular characteristics of carbapenemase-producing Pseudomonas aeruginosa isolates. A total 328 (11.1%, 328/2953) P. isolates from humans were obtained public databases as October 2019. Of which, blaVIM blaIMP genes most prevalent carbapenemases in These possessed 34 distinct sequence types (STs) six predominated: ST357, ST823, ST308, ST233, ST175 ST111. The ST357 ST823 primarily found detected Asia all Europe. ST233 ST111 spread...
Inflammatory responses can induce microvascular and endothelial dysfunction, which is associated with the development of sepsis. This study aimed at examining concentrations plasma tissue factor (TF), von Willebrand (vWF), tumor necrosis factor-α (TNF-α) in patients sepsis determining how septic (SP) regulates TF vWF expression p38 mitogen activated protein kinase (p38 MAPK)/nuclear factor-κB (NF-κB) pathways human cells. The TF, vWF, TNF-α 22 eight healthy controls (HCs) were examined by...
Abstract Objectives Adamantinomatous craniopharyngiomas (adaCP) accounts for 5.6% to 15% of intracranial tumors. High expression chemokine (C‐X‐C motif) ligand 12 (CXCL12, also known as stromal cell‐derived factor 1 [SDF1]) and its receptor CXC type 4 (CXCR4) are widespread in various malignancy via multiple signal transduction pathways. This study aims investigate the mechanism CXCL12/CXCR4 promoting proliferation, migration, invasion adaCP. Methods Quantitative real‐time polymerase chain...
Spinal muscular atrophy (SMA) is a fatal genetic disease, mainly affecting children. A number of recent studies show, aside from lower motor neuron degeneration and skeletal muscles, widespread defects present in the central nervous system (CNS) peripheral non-neuronal cell types SMA patients mouse models, particularly severe forms. However, molecular mechanisms underlying multi-organ manifestations were hardly understood. Here, using histology, flow cytometry gene expression analysis both...
Abstract Recurrent uncomplicated lower urinary tract infections (RULUTIs) are common among women without anatomical or physiological abnormalities and affect of all age groups, races, ethnicities. Herein, we summarized the sources epidemiology, etiology, diagnosis, treatment, prophylaxis, follow-up evaluations in cases RULUTIs. Patients' medical histories, symptoms, signs were recorded. The review showed that urinalysis, culture, sensitivity should be tested before empiric treatment. A...
Objectives To conduct a retrospective analysis of the clinical characteristics and prognosis rhabdomyosarcoma middle ear mastoid (MERMS) in children. Methods Treatment outcome 37 children with MERMS from Beijing Children's Hospital (July 2016–April 2023) were evaluated. Results The median age this cohort was 54 months. Initially, 9 misdiagnosed otitis media and/or granulomas, whereas 11 underwent anti-infective therapy. disease manifested high level local aggressiveness (T2; 83.8%), often...
This study aimed to summarize the clinical and pathological characteristics of Malignant Ectomesenchymoma (MEM) provide an overview available treatment options. A retrospective analysis was conducted on data from 11 children diagnosed with MEM at Beijing Children's Hospital between 2012 2023. The included nine male two female patients, a median age 3 years (range, 1.5-11.0 years). most commonly affected sites were head neck (45.6%), followed by limbs (27.2%) pelvis/abdomen (27.2%). Nine...
Type 2 diabetes, a global health concern has been considered as major risk factor for cardiovascular diseases. Hinokinin, an emerging bioactive lignin, is reported to show wide range of pharmacological activities. However, the protective role and mechanisms Hinokinin against type diabetes-mediated cardiotoxicity are still remains unknown. An experimental diabetic mice model was created by treating animals with high fat diet four weeks intraperitoneal injection streptozotocin (35 mg/kg body...
Abstract Accurate and efficient detection of pathogenic bacteria plays a crucial role in the diagnosis infectious diseases. However, rapid highly sensitive specific clinical samples remains challenging. In this study, we developed ratiometric dual‐signal electrochemical biosensor for ultrasensitive bacteria, based on an aptamer recognition‐induced rolling circle amplification (RCA)/G‐quadruplex strategy. On surface gold electrode chip, used sequence (P1) conjugated to ferrocene (Fc) capture...
The diagnosis and treatment of hemospermia presents significant difficulty, especially if it persists or recurs.In this retrospective study, we assessed whether transurethral seminal vesiculoscopy is feasible effective in the hemospermia.To address complex condition, report our experience a population patients treated with vesiculoscopy.From February 2006 to July 2008, 72 hemospermic underwent examination at urology center.Transurethral was performed by 7-F 8-F rigid ureteroscope.The...
Contents To investigate the causes of occurrence and persistence porcine cystic follicles, we evaluated apoptosis proliferation follicular cells in these cysts. Apoptotic frequencies were examined by TUNEL assay expression regulators (XIAP, bax, bc1‐2 caspase‐3) immunohistochemistry, Western blotting real‐time quantitative PCR; cell activity was PCNA immunohistochemistry vitro cultured granulosa theca cells. The low apoptotic frequency weak proliferative found follicles. Low might be...
Cancer stem cells (CSCs) have been identified in various malignancies, and different properties examined to characterize CSCs: tumorigenicity immunocompromised mice, cell surface markers, label-retaining properties, proliferation as nonadherent spheres. This study explored the consistency efficiency among these methods. Among melanoma lines (A375, A875, MUM-2b, MUM-2c), only A375 MUM-2c grew spheres continuously propagated a defined serum-free medium vitro. Flow cytometry immunofluorescence...
Heart disease is one of the most important causes death in developed countries. Nε-carboxymethyllysine (CML) a major advanced glycation end product formed by combined reactions non-enzymatic and oxidation (glycoxidation), it represents general marker oxidative stress. CML has been suggested to be involved pathogenesis heart disease. Plasma elevated aging, atherosclerosis and/or diabetes. In this study, we measured cardiac levels elucidate its role Cardiac tissues were collected from 105...
Objective/Hypothesis To evaluate the efficacy of initial sirolimus therapy in treatment intractable head and neck lymphatic malformations (LMs) children. Study Design Prospective open‐label study. Methods In this study, Twenty‐seven children diagnosed with LMs were given oral as primary over a minimum 6‐month trial. The major parameter to therapeutic outcome was percentage lesion volume change compared baseline. Average serum concentrations, adverse side effects, monitored throughout study...
The endothelin system plays an important role in the development of pulmonary hypertension. Several studies have suggested that interfering with function will be helpful hypertension treatment. In present study, we investigated preventive and therapeutic effects sildenafil on monocrotaline-treated rats. level mean arterial pressure, right ventricular divide, left septum, small morphologic elastic fiber changes were highly improved treated group (P<0.05). expressions endothelin-1 A type...
BACKGROUND Based on current knowledge, hepatocellular carcinoma (HCC) is a condition with numerous etiologies and risk factors. However, the pathogenesis of HCC remains unclear. AIM To investigate roles senegenin O-GlcNAcylation in growth metastasis HCC. METHODS The levels O-linked N-acetylglucosamine transferase (OGT) cells tissues were detected using western blot analysis. effects proliferation investigated vitro cell counting kit-8 clonogenic assays. potential examined transwell migration...
Recent studies have found that cardiac stem cells (CSCs) are present in the adult heart. CSCs play an important role maintaining balance of number myocardial cells. The purpose this study was to examine characteristics human and their correlation with clinical patients. We collected heart auricles 105 patients (age range, 1–78 years; mean, 55.6 ± 17.0 years) undergoing surgery obtain CSCs. assayed percentage c-kit positive (c-kit + ) flow cytometry. Plasma N ɛ -(carboxymethyl)lysine (CML)...
Postoperative atrial fibrillation (POAF) is associated with increased morality rate, prolonged hospitalization, and reduced long-term survival after surgery. Thus, prediction of POAF important to assess surgical risk provide prophylaxis.It was a prospective study 207 consecutive patients who underwent routine preoperative laboratory testing before thoracic surgery from October 2016 May 2017. Comprehensive data were collected. Then stepwise multivariate logistic regression analysis adopted...