A5068822487- COVID-19 Clinical Research Studies
- Plant Molecular Biology Research
- SARS-CoV-2 and COVID-19 Research
- Fatty Acid Research and Health
- Autophagy in Disease and Therapy
- Long-Term Effects of COVID-19
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Pharmacological Effects and Toxicity Studies
- Eicosanoids and Hypertension Pharmacology
- Epilepsy research and treatment
- Inflammasome and immune disorders
- Light effects on plants
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Plant nutrient uptake and metabolism
- Financial Literacy, Pension, Retirement Analysis
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- SARS-CoV-2 detection and testing
Peking University
2002-2024
John Innes Centre
2021-2024
Ningbo Center for Disease Control and Prevention
2022-2024
Norwich Research Park
2021-2024
Loudi Central Hospital
2020-2021
Center for Disease Control
2020
Taihe Hospital
2018-2019
Hubei University of Medicine
2018-2019
Ningbo University
2016-2018
Ningbo No. 2 Hospital
2018
Abstract Plants use seasonal temperature cues to time the transition reproduction. In Arabidopsis thaliana , winter cold epigenetically silences floral repressor locus FLOWERING LOCUS C ( FLC ) through POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) 1 . This vernalization process aligns flowering with spring. A prerequisite for silencing is transcriptional downregulation of but how this occurs in fluctuating regimes autumn unknown 2–4 Transcriptional repression correlates decreased local levels histone...
Abstract Cellular RNAs are heterogeneous with respect to their alternative processing and secondary structures, but the functional importance of this complexity is still poorly understood. A set alternatively processed antisense non-coding transcripts, which collectively called COOLAIR , generated at Arabidopsis floral-repressor locus FLOWERING LOCUS C ( FLC ) 1 . Different isoforms influence transcriptional output in warm cold conditions 2–7 Here, further investigate function we developed...
Cytotoxin-associated-gene A (CagA) of Helicobacter pylori (H. pylori) is a virulence factor that plays critical roles in H. pylori-induced gastric inflammation. In the present study, biopsies were used for genotyping cagA and vacA genes, determining autophagic activity, severity inflammation response. It was revealed autophagy mucosal tissues infected with cagA-positive strains lower than levels produced by cagA-negative strains, accompanied accumulation SQSTM1 decreased LAMP1 expression....
Studies have shown that some cytokines in COVID-19 patients were elevated. This study aims to assess whether IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 serve as potential diagnostic biomarkers of COVID-19.The above serum non-COVID-19 detected by ELISA SARS-CoV-2 IgM IgG the chemiluminescence method. The independent-sample Mann-Whitney U test was utilised compare cytokine levels different groups courses, Levene T-test T'-test they genders Spearman correlation analyse between with ages...
Abstract The Helicobacter pylori vacuolating cytotoxin (VacA) can promote progressive vacuolation and gastric injury may be associated with human cancer. Increasing evidence indicates that autophagy is involved in the cell death induced by VacA, but specific mechanisms need to further elucidated. We show here VacA could induce increase cancer lines. Further investigations revealed inhibition of decrease VacA-induced AGS cells. Furthermore, numerous dilated endoplasmic reticula (ER) were...
Shiga toxins (Stxs) are a family of cytotoxic proteins that lead to the development bloody diarrhea, hemolytic-uremic syndrome, and central nervous system complications caused by bacteria such as S. dysenteriae, E. coli O157:H7 O104:H4. Increasing evidence indicates macroautophagy (autophagy) is key factor in cell death induced Stxs. However, associated mechanisms not yet clear. This study showed Stx2 induces autophagic Caco-2 cells, cultured line model human enterocytes. Inhibition...
Plants monitor many aspects of their fluctuating environments to help align development with seasons. Molecular understanding how noisy temperature cues are registered has emerged from dissection vernalization in Arabidopsis, which involves a multiphase cold-dependent silencing the floral repressor locus FLOWERING LOCUS C (FLC). Cold-induced transcriptional precedes low probability PRC2 epigenetic switching mechanism. The switch requires absence warm temperatures as well long-term cold...
Fusobacterium nucleatum (F. nucleatum) plays a critical role in gastrointestinal inflammation. However, the exact mechanism by which F. contributes to inflammation is unclear. In present study, it was revealed that could induce production of proinflammatory cytokines (IL-8, IL-1β and TNF-α) reactive oxygen species (ROS) Caco-2 colorectal) adenocarcinoma cells. Furthermore, ROS scavengers (NAC or Tiron) decrease during infection. addition, we observed autophagy impaired cells after The...
Abstract The situation of the coronavirus disease 2019 (COVID‐19) continues to evolve, our study explored significance serum levels matrix metalloproteinase 3 (MMP3) as a marker for patients with COVID‐19. Sixty‐two COVID‐19 in First Hospital Hunan University Chinese Medicine and Loudi Center Diseases Prevention Control, from January March 2020, were sampled novel pneumonia infected group. One hundred thirty‐one cases Medicine, including 67 healthy individuals 64 non‐COVID‐19 inpatients,...
Abstract Objectives Adamantinomatous craniopharyngiomas (adaCP) accounts for 5.6% to 15% of intracranial tumors. High expression chemokine (C‐X‐C motif) ligand 12 (CXCL12, also known as stromal cell‐derived factor 1 [SDF1]) and its receptor CXC type 4 (CXCR4) are widespread in various malignancy via multiple signal transduction pathways. This study aims investigate the mechanism CXCL12/CXCR4 promoting proliferation, migration, invasion adaCP. Methods Quantitative real‐time polymerase chain...
Objective To evaluate and compare long-term effectiveness of five antiepileptic drugs (AEDs) for monotherapy adult patients with focal epilepsy in routine clinical practice. Methods Adult epilepsy, who were prescribed carbamazepine (CBZ), valproate (VPA), lamotrigine (LTG), topiramate (TPM), or oxcarbazepine (OXC) as monotherapy, during the period from January 2004 to June 2012 registered Wenzhou Epilepsy Follow Up Registry Database (WEFURD), included study. Prospective follow-up was...
Ribosome production in eukaryotes requires the complex and precise coordination of several hundred assembly factors, including many small nucleolar RNAs (snoRNAs). However, at present, distinct role key snoRNAs ribosome biogenesis remains poorly understood higher plants. Here we report that a previously uncharacterized C (RUGAUGA)/D (CUGA) type snoRNA, HIDDEN TREASURE 2 (HID2), acts as an important regulator through snoRNA-rRNA interaction. Nucleolus-localized HID2 is actively expressed...
Noncoding polymorphism frequently associates with phenotypic variation, but causation and mechanism are rarely established. single-nucleotide polymorphisms (SNPs) characterize the major haplotypes of Arabidopsis thaliana floral repressor gene FLOWERING LOCUS C (FLC). This noncoding generates a range FLC expression levels, determining requirement for response to winter cold. The adaptive determinant these was shown be autumnal levels expression. Here, we investigate how SNPs influence...
Burkholderia pseudomallei is the causative agent of melioidosis, a disease with high mortality, which prevalent in tropical regions world. A recent study shows that B. can survive inside mammalian cells because its ability to actively evade cell autophagy. However, underlying mechanisms remain unclear. In present study, based on microarray screening, we found ATG10 was downregulated following infection A549 human lung epithelial cells. Forced expression accelerated elimination intracellular...
High-fat (HF) diets and low-grade chronic inflammation contribute to the development of insulin resistance type 2 diabetes (T2D), whereas n-3 polyunsaturated fatty acids (PUFAs), due their anti-inflammatory effects, protect against resistance. Interleukin (IL)-1β is implicated in resistance, yet how PUFAs modulate IL-1β secretion attenuate HF diet-induced remains elusive. In this study, a diet activated NLRP3 inflammasome via inducing reactive oxygen species (ROS) generation promoted...
Histone modifications affect gene expression, but the mechanism and biological consequence of natural variation in histone remain unclear. Here, we generated genome-wide integrated maps H3K27me3 modification transcriptome for Col, C24 their F1 hybrid. A total 1,828 genomic regions showing between Col were identified, most which associated with genic regions. Natural parents could result allelic bias hybrids. Furthermore, found that was negatively correlated expression differences two...
Summary CRISPR Cas9 and other sequence-specific endonucleases are fundamental genome editors supporting gene knockout therapy. A speedy accurate computational allele designer is required for a high through-put mutagenesis pipeline using these new techniques. An automatic system, online (COD), was created to screen targets off-targets, as well provide genotyping strategies. rat model successfully genotyped under the direction of this system confirming its ability predict real off-targets....