A5103037600- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 detection and testing
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Herbal Medicine Research Studies
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Burn Injury Management and Outcomes
- Influenza Virus Research Studies
- Connective tissue disorders research
- Congenital Diaphragmatic Hernia Studies
- Apelin-related biomedical research
- Metabolism and Genetic Disorders
- Fibroblast Growth Factor Research
- Angiogenesis and VEGF in Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Extracellular vesicles in disease
Suzhou Guangji Hospital
2024-2025
Soochow University
2021-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2020-2025
Shanghai Jiao Tong University
2024
Zhongshan Hospital
2015-2023
Shanghai Medical College of Fudan University
2017-2023
Hunan University
2022
Second Affiliated Hospital of Soochow University
2021
National Patient Safety Foundation
2021
Anhui University
2020-2021
Studies have shown that some cytokines in COVID-19 patients were elevated. This study aims to assess whether IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 serve as potential diagnostic biomarkers of COVID-19.The above serum non-COVID-19 detected by ELISA SARS-CoV-2 IgM IgG the chemiluminescence method. The independent-sample Mann-Whitney U test was utilised compare cytokine levels different groups courses, Levene T-test T'-test they genders Spearman correlation analyse between with ages...
Xueshuantong injection (Lyophilized) (XSTI) is widely used to treat cardiovascular and cerebrovascular diseases. However, anaphylactoid reactions (ARs) are frequently reported as one of its side effects, the mechanisms ARs their relationship with different immune status still not well understood. This article aims examine sensitizing effect XSTI, explore impact normal immunocompromised states on ARs, analyze AR-related metabolic pathways by metabolomics. An mouse model was established...
<title>Abstract</title> Background Cognitive impairment in individuals with Major Depressive Disorder (MDD) may have an association the levels of Vascular Endothelial Growth Factor (VEGF). Methods In this case-control study, we recruited 60 patients diagnosed depression (33 males and 27 females, a mean age 41.17 years) from outpatient or inpatient unit Suzhou Guangji Hospital. Additionally, healthy controls (28 32 37.20 were local community Xiangcheng District. Subsequently, measured serum...
Abstract Many self-renewal-promoting factors of embryonic stem cells (ESCs) have been implicated in carcinogenesis, while little known about the genes that direct ESCs exit from pluripotency and regulate tumor development. Here, we show transcripts Gadd45 family genes, including Gadd45a, Gadd45b, Gadd45g, are gradually increased upon mouse ESC differentiation. Upregulation members decreases cell proliferation induces endodermal trophectodermal lineages. In contrast, knockdown can delay...
Abstract Lung cancer has high mortality, often accompanied with systemic metabolic disorders. The present study aimed at defining values of trans‐nodules cross‐clinical phenomic and lipidomic network layers in patients adenocarcinoma (ADC), squamous cell carcinomas, or small lung (SCLC). We measured plasma profiles found that altered lipid panels concentrations varied among subtypes, genders, ages, stages, metastatic status, nutritional clinical phenome severity. It was shown...
The tumor necrosis factor-α (TNF-α) and monocytic cells play a critical role in the development of atherosclerosis, which is major cause coronary heart disease (CHD). In this work, we investigated effect excess TNF-α on monocytes blood found that from CHD patients had potential to directly form cholesteryl ester (CE)-laden under vitro incubation with oxLDL. plasma levels proinflammatory cytokines, such as TNF-α, interleukin 6 (IL-6), C reactive protein (CRP), were significantly higher than...
Abstract T cells, with numerous classifications, are vital components of the adaptive immune system, which function to maintain homeostasis protect against pathogens. With rapid development single‐cell RNA sequencing (scRNA‐seq), specificity and functions high‐resolution characterizations identities cells continuously explored discovered. The exact cell provide new insights for deeply understanding heterogeneity identification previously unrecognized subsets. accuracy cluster annotation...
We explored the association between plasma growth differentiation factor 15 (GDF-15) levels and chronic heart failure (CHF) in coronary disease patients. measured GDF-15 N-terminal pro-B-type natriuretic peptide (NT-proBNP) 269 untreated patients (98 with CHF, 84 without 87 control patients) using an enzyme-linked immunosorbent assay. All subjects were examined by echocardiography left ventricular ejection fraction. found that atherosclerosis CHF [median 1622.48 (25-75th percentile:...
At the end of March 2013, first case human infection with avian influenza A(H7N9) virus was confirmed in Shanghai. From April to May 18 patients were hospitalized Shanghai Public Health Clinical Center, and finally, 12 them survived. The short-term prognosis these had been described previously,[1] but long-term remained unclear. September November 5 survivors discharged from Center admitted Zhongshan Hospital, Fudan University. Data demographic characteristics, diagnosis, underlying...
Abnormal glucose metabolism brings out joint inflammation and destruction in rheumatoid arthritis (RA). The aim of this study was to evaluate the potential circulating hexokinase-2 (HK2) peripheral blood mononuclear cells (PBMCs) (RA) patients.PBMCs were obtained from patients with RA or osteoarthritis (OA) healthy controls (HCs). expression HK2 assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). C-reactive protein (CRP) level, erythrocyte sedimentation rate...
Embryonic stem cells (ESCs) are progenitor that retain the ability to differentiate into various cell types and necessary for tissue repair. Improving culture conditions maintain pluripotency of ESCs in vitro is an urgent problem field regenerative medicine. Here, we reveal Spautin-1, a specific small-molecule inhibitor ubiquitin-specific protease (USP) family members USP10 USP13, promotes maintenance self-renewal mouse vitro. Functional studies only knockdown but not USP10, capable...
The serum proteins creatine kinase isoenzyme MB (CKMB) and cardiac troponin T are classic biomarkers of ischemic damage in clinical practice, which can sensitively detect myocardial necrosis, while other two proteins, ischemia-modified albumin N-terminal pro-B-type natriuretic peptide (NT-proBNP), have been recently identified as novel ischemia. In this study, the four were detected sera from 44 eligible patients with suspected coronary heart disease (CHD) before after treadmill exercise...
The identification of novel mechanisms to maintain embryonic stem cell (ESC) pluripotency is crucial importance, because the currently used culture conditions are not suitable for ESCs from all species. In this study, we showed that protein kinase D (PKD) inhibitor CID755673 (CID) able undifferentiated state mouse in combination with mitogen-activated (MEK) inhibitor. expression levels PKD members, including PKD1, PKD2 and PKD3, were low but significantly increased under differentiation...
Abstract Background Classical Ehlers‐Danlos syndrome (cEDS) is a heterogeneous connective tissue disorder that mainly results from the germline mutation of COL5A1 and COL5A2 . The majority mutations reported to date represent structural mutations, including missense or in‐frame exon‐skipping splice mutations. only synonymous was expected affect on splicing exon 29 by prediction programs which should be further confirmed. Methods Whole exome sequencing performed identify genetic variants...
COVID-19 has become a global pandemic, and close contacts asymptomatic patients are worthy of attention.A total 1844 people in with 76 were investigated, nasopharyngeal swabs venous blood collected for centralized medical quarantine observation. Real-time fluorescence was used to detect SARS-CoV-2 nucleic acid all contacts, the colloidal gold method serum-specific antibodies. Levels IgM- IgG-specific antibodies detected quantitatively through chemiluminescence from first turned negative date...
Changes of serum IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 in COVID-19 patientsQingqing Lu1,Zhenhua Zhu2,Chaochao Tan3, Hui Zhou2,Yan Hu2,Ge Shen4,Pan Zhu4,Gang Yang4,Xiaobing Xie2△(1. Hunan University Chinese Medicine, Changsha Postal Code: 410208; 2. The First Hospital 410007; 3. Provincial People's Hospital, 410005; 4.Loudi Center for Disease Control Prevention,Loudi 417000)△ Correspondence author, E-mail:xxiaobing888@163.com Abstract: Background purpose: Studies have shown that...