A5100406589- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Natural Compound Pharmacology Studies
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Flavonoids in Medical Research
- Ubiquitin and proteasome pathways
- Natural product bioactivities and synthesis
- Cancer-related Molecular Pathways
- Synthesis of Organic Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Probiotics and Fermented Foods
- Cancer Immunotherapy and Biomarkers
- Fermentation and Sensory Analysis
- Cancer-related gene regulation
- Immune cells in cancer
- Phytochemical Studies and Bioactivities
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Pancreatic and Hepatic Oncology Research
- Hippo pathway signaling and YAP/TAZ
- Food Quality and Safety Studies
- Epigenetics and DNA Methylation
Tianjin Medical University
1990-2025
Bengbu Medical College
2013-2025
Kunming University of Science and Technology
2018-2025
Beijing Academy of Agricultural and Forestry Sciences
2019-2025
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
Jinan University
2018-2025
Nanjing Medical University
2000-2025
China Medical University
2019-2025
Affiliated Hospital of Qingdao University
2020-2025
BACKGROUND Predicting survival is uniquely difficult in patients with pancreatic cancer who receive chemotherapy. The authors developed a systemic inflammation response index (SIRI) based on peripheral neutrophil, monocyte, and lymphocyte counts evaluated the ability of SIRI to predict received METHODS was training set 177 had advanced palliative patient's after chemotherapy validated 2 independent cohorts (n = 397). RESULTS Compared an <1.8, cohort ≥1.8 shorter time progression (TTP)...
<b>Objective</b> To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) obesity. <b>Design</b> Prospective cohort study. <b>Setting</b> Health professionals United States. <b>Participants</b> 9623 women from Nurses’ Study, 6379 men Professionals Follow-up a replication 21 421 Women’s Genome Study. <b>Main outcome measure</b> Repeated measurement BMI over follow-up. <b>Results</b> There was an interaction risk score based...
Abstract The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) galactooligosaccharides (GOS) on glycemia during oral tolerance test (OGTT) intestinal microbiota. A double-blind cross-over study performed 35 adults treated FOS GOS for 14 days (16 g/day). Faeces sampling, OGTT...
Abstract As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute dysregulated oncogenic pathways. Integration of into networks offers opportunities protein–protein interactions (PPIs) with functional and therapeutic significance. Here, we report generation cancer-focused PPI network, termed OncoPPi, identification >260 cancer-associated PPIs not in other large-scale interactomes. hubs new regulatory mechanisms for like MYC , STK11...
Abstract Diffuse large B cell lymphoma (DLBCL) is the commonest disorder derived from B-lymphocytes. Inhibiting immune checkpoint through naturalizing programmed death-1 (PD-1) and death ligand 1 (PD-L1) proved to be a successful therapeutic regime for lymphoma. Long non-coding RNAs (lncRNAs) are unceasingly reported promising biological targets cancer therapies. This study planned explore regulation of small nucleolar RNA host gene 14 (SNHG14) on DLBCL. SNHG14 level in DLBCL samples lines...
Abstract ( R,S )-ketamine elicits rapid-acting and sustained antidepressant actions in treatment-resistant patients with depression. R produces longer-lasting effects than S rodents; however, the precise molecular mechanisms underlying of remain unknown. Using isobaric Tag for Relative Absolute Quantification, we identified nuclear receptor-binding protein 1 (NRBP1) that could contribute to different antidepressant-like two enantiomers chronic social defeat stress (CSDS) model. NRBP1 was...
Abstract Objective To examine, in an inception cohort of systemic lupus erythematosus (SLE) patients, the association between neuropsychiatric (NP) events and anti–ribosomal P (anti‐P), antiphospholipid (lupus anticoagulant [LAC], anticardiolipin), anti–β2‐glycoprotein I, anti–NR2 glutamate receptor antibodies. Methods NP were identified using American College Rheumatology case definitions clustered into central/peripheral diffuse/focal events. Attribution to SLE was determined decision...
Abstract Background Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive response contribute to psoriasis pathogenesis. The agents able attenuate keratinocytes are considered be potentially useful for treatment. Daphnetin exhibits broad bioactivities including anti-proliferation anti-inflammatory. This study aims evaluate the anti-psoriatic potential of daphnetin in vitro vivo, explore underlying mechanisms. Methods HaCaT was stimulated with...
Early detection and prognosis prediction are critical to improve patient survival in pancreatic cancer. This study aimed investigate whether interleukins could serve as indicators of cancer.Sixty-eight patients with cancer were enrolled the during period between 2012 2014. The serum levels a broad spectrum these determined, including IL-1β, IL-2, IL-6, IL-8, IL-10, IL-13, IL-15, IL-23.IL-6, IL-10 showed significant positive correlations each other. Moreover, high independently strongly...
The analysis of codon usage is a good way to understand the genetic and evolutionary characteristics an organism. However, there are only few reports related with domesticated silkworm, Bombyx mori (B. mori). Hence, B. was analyzed here reveal constraint factors it could be helpful improve bioreactor based on mori. A total 1,097 annotated mRNA sequences from were analyzed, revealing weak bias. It also shows that gene expression level GC content, amino acids higher general average...
Abstract The transcription factor erythroid 2-related 2 (Nrf2) and brain-derived neurotrophic (BDNF) play a key role in depression. However, the molecular mechanisms underlying crosstalk between Nrf2 BDNF depression remain unclear. We examined whether regulates of Bdnf by binding to its exon I promoter. Furthermore, brain regions from mice with depression-like phenotypes was examined. regulated Activation sulforaphane (SFN) showed fast-acting antidepressant-like effects activating as well...
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance antiangiogenic therapy. The current mechanisms underlying vessel have mainly focused on "hijacker" tumor cells, whereas the function of "hijackee" sinusoidal blood vessels not explored. Here, we found that occurrence in bevacizumab-resistant CRCLM xenografts was associated with increased expression fibroblast activation protein α (FAPα) co-opted hepatic stellate cells (HSCs), which...
Transglutaminase (TGase) was added to soy protein isolate (SPI) dispersion after the combination treatment of high intensity ultrasound (HIU) and hydrostatic pressure (HHP) catalyze formation cold gel, which used encapsulate riboflavin. The structure, physicochemical properties in vitro digestion characteristics riboflavin-loaded SPI gel were investigated. HIU-HHP combined enhanced strength, water retention, elastic property, thermal stability denaturation degree gels, improved network...