A5115592205- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory Biomarkers in Disease Prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- interferon and immune responses
- Neurosurgical Procedures and Complications
- Immune Response and Inflammation
- Acute Ischemic Stroke Management
- Sperm and Testicular Function
- Head and Neck Surgical Oncology
- Sepsis Diagnosis and Treatment
- Reproductive Biology and Fertility
- Immune cells in cancer
- Cerebrospinal fluid and hydrocephalus
- Cancer-related molecular mechanisms research
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Nasolacrimal Duct Obstruction Treatments
- Gastric Cancer Management and Outcomes
- Viral Infections and Vectors
- Chronic Kidney Disease and Diabetes
- Pancreatic and Hepatic Oncology Research
Chinese Academy of Agricultural Sciences
2024-2025
Shandong University
2012-2025
Gansu Agricultural University
2024-2025
Zhengzhou University
2012-2025
Yichang Central People's Hospital
2025
China Three Gorges University
2013-2025
Ningxia Medical University
2021-2025
Cotton Research Institute
2025
West China Hospital of Sichuan University
2021-2024
Zhengzhou Institute of Machinery
2024
BACKGROUND Predicting survival is uniquely difficult in patients with pancreatic cancer who receive chemotherapy. The authors developed a systemic inflammation response index (SIRI) based on peripheral neutrophil, monocyte, and lymphocyte counts evaluated the ability of SIRI to predict received METHODS was training set 177 had advanced palliative patient's after chemotherapy validated 2 independent cohorts (n = 397). RESULTS Compared an <1.8, cohort ≥1.8 shorter time progression (TTP)...
Mutations in or dys-regulation of the TDP-43 gene have been associated with proteinopathy, a spectrum neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular cellular defects, however, remain unclear. Here, we report systematic study combining analyses patient brain samples animal models for proteinopathy. Electron microscopy (EM) revealed prominent mitochondrial impairment, abnormal cristae loss cristae;...
Abstract Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pathway in the adipose, liver, kidney tissues. However, role mtDNA progression DCM unclear. In this study, with an obesity-related mouse model established feeding db/db mice a high-fat diet...
AIM:To establish the methylation profile of promoter CpG islands 31 genes that might play etiological roles in colon carcinogenesis. METHODS:The specific PCR conjunction sequencing verification was used to methylationprofile colorectal cancer (n = 65), neighboring non-cancerous tissues 5), adenoma 8), and normal mucosa 1).Immunohistochemically, expression 10 assessed on home-made tissue microarrays from 58 patients.The correlation tumor changes with each clinical-pathologic features...
Virus infection leads to the activation of transcription factor IRF3 and subsequent production type I inteferons, which induce various antiviral genes called interferon stimulated (ISGs) eliminate viral infection. requires phosphorylation, dimerization nuclear translocation. However, mechanisms for termination in nucleus are elusive. Here we report identification TRIM26 negatively regulate IFN-β response by targeting IRF3. bound promoted its K48-linked polyubiquitination degradation nucleus....
Objectives ‘National Special Stewardship in the Clinical Use of Antibiotics’ was put forward July 2011 China. We aimed to retrospectively evaluate impact antimicrobial stewardship (AMS) managed by clinical pharmacists on antibiotic utilisation, prophylaxis and resistance (AMR). Design This a retrospective observational study trends use AMR context AMS. Setting Beijing Chaoyang Hospital, 1400-bed tertiary hospital, Data participants Antibiotic prescriptions from 820 doctors included all...
Background: Coronavirus disease-2019 (COVID-19) epidemic is spreading globally. Sex differences in the severity and mortality of COVID-19 emerged. This study aims to describe impact sex on outcomes COVOD-19 with a special focus effect estrogen. Methods: We performed retrospective cohort which included 413 patients (230 males 183 females) from three designated hospitals China follow up time January 31, 2020, April 17, 2020. Women over 55 were considered as postmenopausal according previous...
In recent years, a small number of cells that have stem cell properties were identified in human gliomas called brain tumor (BTSCs), which thought to mainly contribute the initiation and development could be by surface marker CD133. However, studies indicated expression CD133 might regulated environmental conditions such as hypoxia there CD133(-) BTSCs. Genetic mouse models demonstrated some originated from transformed neural (NSCs). Therefore, we investigated CD15, for NSCs, spheres derived...
The systemic inflammation response index (SIRI) is a useful tool for predicting prognosis in some types of cancer. In this retrospective study, we evaluated the efficacy SIRI overall survival hepatocellular carcinoma (HCC) patients following local or therapy. A cutoff value 1.05 was identified using ROC analysis training patient cohort. validation cohort, revealed that median longer HCC with scores < than those ≥ 1.05. Cox cohort demonstrated associated and more predictive AFP level...
Recognition of RNA virus through TLR and RIG-I-like receptor results in rapid expression type I IFNs, which play an essential role host antiviral responses. However, the mechanisms to terminate production IFNs are not well defined. In current study, we identified a member tripartite motif (TRIM) family, TRIM38, as negative regulator TLR3/4- RIG-I-mediated IFN-β signaling. Knockdown TRIM38 by small interfering resulted augmented activation IFN regulatory factor 3 enhanced IFN-β, whereas...
Background: Nanobiotechnology can provide more efficient tools for diagnosis, targeted and personalized therapy, increase the chances of brain tumor treatment being successful. Use nanoparticles is a promising strategy overcoming blood–brain barrier delivering drugs to brain. Gelatin-siloxane (GS) modified with Tat peptide enhance plasmid DNA transfection efficiency compared commercial reagent. Methods: SynB-PEG-GS are membrane-penetrable, cross deliver drug its target site in The delivery...
The Belt and Road Initiative (BRI) stands as the most ambitious infrastructure project in history, marked by its scale of investment, extensive geographical reach across continents countries, a diverse array projects from roads to digital networks. While BRI's environmental sustainability has raised concerns, impacts construction materials used these have been overlooked, especially developing countries. Here, we map account for embodied BRI integrating, first time, official governmental...
Pancreatic lipase serves as a primary trigger for hyperlipidemia and is also crucial target in the inhibition of hypercholesterolemia. By synthesizing anti-hypercholesterolemic drugs such atorvastatin, which are used to treat hypercholesterolemia, there were some side effects associated with long-term use statins. Based on this idea, present study, we identified peptides that inhibited PL by virtual screening vitro activity assays. In addition, delve into underlying mechanisms, undertook...
Aphis gossypii Glover (Hemiptera: Aphididae) causes considerable damage to crop yields globally. Solanum nigrum (Solanales: Solanaceae), an annual malignant weed, serves as a crucial weed host for A. . However, the potential mechanisms by which adapts different hosts during transition between crops, such Gossypium hirsutum (Malvales: Malvaceae) and S. remain elusive. We calculated life table parameters of after rearing on ten generations. The fifth generation (T5) exhibited strongest...