A5101697641- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Wildlife Ecology and Conservation
- Hedgehog Signaling Pathway Studies
- Species Distribution and Climate Change
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Environmental Changes in China
- Water Quality Monitoring and Analysis
- Birth, Development, and Health
- RNA modifications and cancer
- Avian ecology and behavior
- Cancer-related molecular mechanisms research
- Biochemical and Molecular Research
- Autophagy in Disease and Therapy
- Flavonoids in Medical Research
- Ecology and Vegetation Dynamics Studies
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
Nanjing University
2025
Shanghai Chengtou (China)
2025
Jilin University
2024
China Telecom (China)
2024
China Telecom
2024
Wenzhou Polytechnic
2022-2024
Shanghai Medical College of Fudan University
2013-2023
Fudan University Shanghai Cancer Center
2013-2023
Central South University
2023
Kunming Institute of Zoology
2016-2023
BACKGROUND Predicting survival is uniquely difficult in patients with pancreatic cancer who receive chemotherapy. The authors developed a systemic inflammation response index (SIRI) based on peripheral neutrophil, monocyte, and lymphocyte counts evaluated the ability of SIRI to predict received METHODS was training set 177 had advanced palliative patient's after chemotherapy validated 2 independent cohorts (n = 397). RESULTS Compared an <1.8, cohort ≥1.8 shorter time progression (TTP)...
Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression metastasis in various malignancies. The aim of this retrospective study was evaluate the prognostic significance pre-treatment systemic immune-inflammation index (SII) patients advanced pancreatic cancer. In total, 419 diagnosed cancer, between January 2011 December 2015, were retrospectively enrolled. SII developed based on a training set 197 from 2013 validated an independent cohort 222...
Pancreatic cancer (PC) is a highly lethal malignancy that requires effective novel therapies. M2 macrophages are abundant in the PC microenvironment and promote progression. Exosomes emerging mediators of crosstalk between cells microenvironment. This study was conducted to explore role macrophage-derived exosomes PC.Exosomes derived from were extracted. miR-193b-3p TRIM62 overexpressed or silenced examine their function PC. Luminescence assays used investigate interaction TRIM62. Cell...
Long non-coding RNA LINC00346 has been recently suggested as a prognostic marker in pancreatic cancer. However, its biological function cancer not yet determined. In this study, we attempted to ascertain the role of regulating aggressiveness cancer.The effects overexpression and knockdown on proliferation, cell cycle progression, apoptosis, gemcitabine resistance were investigated. Bioinformatic analysis, luciferase reporter assay, immunoprecipitation assay performed search for potential...
Polybrominated diphenyl ethers (PBDEs)-induced neurotoxicity is closely associated with mitochondrial abnormalities. Mitochondrial fusion and fission dynamics are required for the maintenance of homeostasis. However, little known about how PBDEs disrupt this whether such disruption contributes to impaired neurodevelopment. Methods: We investigated effects 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47), dominant congener in human samples, on using PC12 cells, a well-defined vitro...
Apoptosis is involved in 2,2',4,4'- tetrabromodiphenyl ether (PBDE-47)-induced developmental neurotoxicity. However, little known about the role of autophagy, especially its relationship with apoptosis underlying such neurotoxic process. Methods: Using female Sprague-Dawley rats exposed to low-dose PBDE-47 (0.1, 1.0 and 10 mg/kg/day) from pre-pregnancy until weaning offspring mimic human exposure, we investigated effects on autophagy relation cognitive impairment adult rats. We also...
Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, roles unknown. In this study, disrupted ciliogenesis was cancer cells pancreatic tissues, which facilitated oncogene-induced normal (HPDE6C7) NIH3T3 through activating mevalonate (MVA) pathway. Disruption up-regulated MVA enzymes β catenin-T factor (TCF) signaling, synchronized with sterol regulatory element binding transcription 2 (SREBP2), regulation by β-catenin-TCF signaling...
It is a therapeutic strategy for cancers including pancreatic to inhibit proteasome activity. Disulfiram (DSF) may bind copper (Cu) form DSF–Cu complex. capable of inducing apoptosis in cancer cells by inhibiting DSF rapidly converted diethyldithiocarbamate (DDTC) within bodies. Copper(II) absorbed bodies reduced copper(I) when it enters cells. We found that DDTC and could binuclear complex which might be entitled DDTC–Cu(I), had been synthesized us the laboratory. This study investigate...
Abstract High‐sensitivity, low‐power ultraviolet (UV) detection remains a major challenge in optoelectronics, with complex physical mechanisms requiring exploration as devices transition from thin‐film to low‐dimensional structures. Herein, high‐performance AlGaN p‐i‐n photodetector featuring vertical nanocolumn‐array architecture is presented. The device demonstrates an exceptional external quantum efficiency of 1090% and high responsivity 3 A W −1 at 0 V, significantly showcasing...
We aimed to evaluate the efficacy and safety of oxaliplatin, 5-fluorouracil (5-FU), leucovorin (LV) (FOLFOX-4) as second-line treatment in patients with advanced biliary tract cancer (BTC) failing gemcitabine/cisplatin first-line chemotherapy.Thirty-seven BTC refractory chemotherapy were included study. FOLFOX-4 regimen consisted oxaliplatin (85 mg/m(2)) a 2-hour infusion on day 1 LV (200 mg/m(2)/day) followed by 5-FU bolus (400 22-hour (600 for two consecutive days every 2 weeks. The...
Recent studies have suggested that sonic Hedgehog (Shh) signaling pathway is aberrantly activated in cancer stem cells (CSCs). A seven-herb Chinese medicinal formula composed of Amorphophallus rivieri Durieu, Oldenlandia diffusa (Wild) Roxb, Scutellaria barbata D. Don, Gynostemma pentaphyllum (Thunb.) Mak and Amomum cardamomum L, i.e. Qingyihuaji (QYHJ) formula, has been shown to inhibit proliferation pancreatic CSCs by inhibiting Shh thereby prolong the overall survival patients. Mass...
BACKGROUND: Circulating microRNAs (miRNAs) are emerging as novel biomarkers for various types of cancer including pancreatic (PC). OBJECTIVE: We aimed to explore the diagnostic and prognostic significance serum miR-373 in PC. METHODS: In current study, we recruited a total 103 PC p atients, 30 patients with benign tumor, 20 chronic pancreatitis 50 healthy volunteers. Total RNA was isolated from all blood samples, relative expression levels were detected by reverse transcription-quantitative...
Objective: The phenomenon that cancer cells avidly exhibit glycolysis with lactate secretion and decrease in mitochondrial activity under aerobic conditions is known historically as the Warburg effect. Rho GTPase-activating protein 4 (ARHGAP4) an important negative regulator of signaling pathway was associated tumorigenesis. Our study aims to determine function ARHGAP4 controlling glycolytic process pancreatic vitro possible molecular mechanism involved. Methods: PKM2 expressions tissues...
Abstract β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in Wnt signaling pathway that mediates multiple cellular processes, such cell migration invasion. HDAC2 (histone deacetylase 2), maintains histone H3 deacetylated state promoter region Wnt-targeted genes where bound, negatively regulating activation. However, regulation HDAC2/β-catenin remains unclear. Here, we report ARHGAP4 new regulator regulates invasion pancreatic cancer well...
Background/Aims: Although oxaliplatin is one of the most effective chemotherapeutic drugs used to treat colorectal cancer (CRC), long-term administration usually induces acquired drug resistance during course treatment. Thus, there an urgent need explore novel strategies improve efficiency therapy. The aim this study was effect microRNA-122 (miR-122) on reversing in CRC. Methods: expression miR-122 CRC cells examined by quantitative reverse transcriptase real-time PCR. cytotoxicity against...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient prognosis. A cellular stress response mechanism called the unfolded protein (UPR) has been implicated in PDAC progression. More recently, nucleobindin 1 (NUCB1), calcium-binding protein, shown to control UPR but its precise role not explored. Here, we found that downregulation of NUCB1 was associated prognosis patients PDAC. Functionally, overexpression suppressed pancreatic cell proliferation and showed...