A5100365688- Dental materials and restorations
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Dental Research and COVID-19
- Endodontics and Root Canal Treatments
- Mesenchymal stem cell research
- Dental Erosion and Treatment
- Periodontal Regeneration and Treatments
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Dental Implant Techniques and Outcomes
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Dental Trauma and Treatments
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Retinal Diseases and Treatments
- Orthodontics and Dentofacial Orthopedics
- Titanium Alloys Microstructure and Properties
- Glaucoma and retinal disorders
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Corneal Surgery and Treatments
Songshan Lake Materials Laboratory
2024-2025
Anhui Medical University
2022-2025
Capital Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2022-2025
Kunming University of Science and Technology
2025
Zhejiang University
2025
Jinzhou Medical University
2023-2025
Zhongda Hospital Southeast University
2025
South China Normal University
2023-2025
The University of Texas Medical Branch at Galveston
2021-2024
Background— Essential hypertension has been recognized as a disease resulting from combination of environmental and genetic factors. Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy heart failure. However, little is known about the roles miRNAs essential hypertension. Methods Results— Using microarray-based miRNA expression profiling, we compared expressions plasma samples 13 hypertensive patients 5 healthy control subjects. Twenty-seven were found to...
Abstract Hard tissue repair and regeneration cost hundreds of billions dollars annually worldwide, the need has substantially increased as population aged. tissues include bone tooth structures that contain calcium phosphate minerals. Smart biomaterial-based engineering regenerative medicine methods have exciting potential to meet this urgent need. biomaterials constructs refer possess instructive/inductive or triggering/stimulating effects on cells by material’s responsiveness internal...
3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the printing technique has good control over macro-sturctures of Ti, surface properties that affect tissue response are beyond its control, adding need tailored treatment to improve osseointegration capacity. Here, one step microarc oxidation (MAO) process was applied a Ti6Al4V (Ti64) scaffold endow with homogeneous layer microporous TiO2 and significant amounts amorphous...
Abstract Background Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of (CSU) in which functional IgG autoantibodies to IgE or its high‐affinity receptor (FcεRI) induces mast cell degranulation and subsequent symptom development. However, it has not been tightly characterized. This study aimed better define the clinical immunological features explore potential biomarkers aiCSU. Methods was a multinational, multicenter 182 CSU patients. The studied included: activity...
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and common cause end-stage renal disease (ESRD). Mesenchymal stem cells (MSCs) possess potent anti-inflammatory immunomodulatory properties, which render them an attractive therapeutic tool for tissue damage inflammation.This study was designed to determine the protective effects underlying mechanisms human umbilical cord-derived MSCs (UC-MSCs) on streptozotocin-induced DN. Renal function histological staining were used...
Antibacterial bonding agents could combat recurrent caries at the tooth-composite margins. The objectives of this study were to develop novel antibacterial dentin primers containing quaternary ammonium dimethacrylate (QADM) and nanoparticles silver (NAg), investigate effects on bond strength dental plaque microcosm biofilms for first time. Scotchbond Multi-Purpose ("SBMP") agent was used. QADM NAg incorporated into SBMP primer, yielding 4 primers: primer (control), control + 10% (mass),...
Dental composites are commonly used restorative materials; however, secondary caries due to biofilm acids remains a major problem. The objectives of this study were (1) develop composite containing quaternary ammonium dimethacrylate (QADM), nanoparticles silver (NAg), and amorphous calcium phosphate (NACP), (2) conduct the first investigation mechanical properties, response acid production vs water-ageing time from 1 day 12 months. A 4 × 5 design was utilized, with four (NACP-QADM composite,...
Microglia-mediated inflammatory responses have been shown to play a crucial role in Parkinson's disease. In addition, exosomes derived from mesenchymal stem cells anti-inflammatory effects the treatment of variety diseases. However, whether they can protect neurons disease by inhibiting microglia-mediated is not yet known. this study, were isolated human umbilical cord and injected into 6-hydroxydopamine-induced rat model We found that through tail vein lateral ventricle absorbed...
Pancreatic cancer (PC) is a highly lethal malignancy that requires effective novel therapies. M2 macrophages are abundant in the PC microenvironment and promote progression. Exosomes emerging mediators of crosstalk between cells microenvironment. This study was conducted to explore role macrophage-derived exosomes PC.Exosomes derived from were extracted. miR-193b-3p TRIM62 overexpressed or silenced examine their function PC. Luminescence assays used investigate interaction TRIM62. Cell...
The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets urgently required. We conducted proteome-wide Mendelian randomization (MR) colocalization analysis to pinpoint potential OC. Data on protein quantitative trait loci (pQTL) 734 plasma proteins were obtained from large genome-proteome-wide association studies. Genetic associations with OC derived the Ovarian Cancer Association Consortium, which included 25,509 cases 40,941 controls. MR was performed...