A5032842399- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Gastrointestinal motility and disorders
- Cardiovascular Function and Risk Factors
- Clostridium difficile and Clostridium perfringens research
- Lipid metabolism and disorders
- Microplastics and Plastic Pollution
- Circular RNAs in diseases
- Gut microbiota and health
- Chronic Disease Management Strategies
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Cardiac Health and Mental Health
Shantou University
2015-2025
Second Affiliated Hospital of Shantou University Medical College
2012-2025
Shantou University Medical College
2016-2023
Kailuan General Hospital
2022
Capital Medical University
2011-2016
Beijing Chao-Yang Hospital
2016
Dana-Farber Cancer Institute
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
First Affiliated Hospital of Shantou University Medical College
2010
The appropriate target for systolic blood pressure to reduce cardiovascular risk in older patients with hypertension remains unclear.
Background— Essential hypertension has been recognized as a disease resulting from combination of environmental and genetic factors. Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy heart failure. However, little is known about the roles miRNAs essential hypertension. Methods Results— Using microarray-based miRNA expression profiling, we compared expressions plasma samples 13 hypertensive patients 5 healthy control subjects. Twenty-seven were found to...
Abstract Background It has been suggested that the baseline triglyceride-glucose (TyG) index, a simple surrogate measure for insulin resistance, is significantly associated with occurrence of stroke. Nevertheless, impact longitudinal patterns TyG on stroke risk in hypertensive patients still unknown. Hence, this study aimed to investigate association between index trajectory and among patients. Methods This prospective included 19,924 from Kailuan Study who underwent three waves survey were...
Background: Studies have demonstrated that remnant cholesterol is correlated with the risk of ischemic stroke. However, it unknown whether visit-to-visit variability in concentration affects We sought to examine role subsequent development stroke general population. Methods: performed a post hoc analysis including eligible participants from Kailuan Study cohort who underwent 3 health examinations and were free atrial fibrillation, myocardial infarction, stroke, cancer, or known...
Abstract Background A single measurement of the triglyceride-glucose (TyG) index, a simple and reliable surrogate marker insulin resistance, is associated with ischemic stroke. However, evidence for an effect long-term elevation in TyG index on stroke limited. Therefore, we evaluated relationship between cumulative exposure risk Methods total 54,098 participants Kailuan study who had not experienced underwent three measurements fasting blood glucose triglycerides during 2006–2007, 2008–2009,...
Abstract Background Concurrent atherogenic dyslipidemia and elevated inflammation are commonly observed in overt hyperglycemia have long been proposed to contribute diabetogenesis. However, the temporal relationship between them effect of their cumulative co-exposure on future incident type 2 diabetes (T2D) remains unclear. Methods Longitudinal analysis data 52,224 participants from a real-world, prospective cohort study (Kailuan Study) was performed address high-sensitivity C-reactive...
Abstract Background High triglyceride-glucose index (TyG) is a major risk factor for heart failure, but the long-term effect of high TyG on developing failure remains unclear. Therefore, we aimed to determine relationship between cumulative exposure and failure. Methods A total 56,149 participants from Kailuan Study, who participated in three consecutive health examinations 2006, 2008, 2010 had no history or cancer were recruited this study. The was calculated as weighted sum (value × time)...
Abstract Background Atherogenic index of plasma (AIP) has been demonstrated as a surrogate marker for ischemic stroke, but there is limited evidence the effect long-term elevation AIP on stroke. Therefore, we aimed to characterize relationship between cumulative exposure and risk Methods A total 54,123 participants in Kailuan Study who attended consecutive health examinations 2006, 2008, 2010 had no history stroke or cancer were included. The time-weighted (cumAIP) was calculated weighted...
Although nonalcoholic fatty liver disease (NAFLD) is commonly seen in metabolic abnormalities patients, NAFLD also occurred the non-obese individuals. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) considered as a predictive factor NAFLD. However, it still difficult confirm correlation TG/HDL-C with among Chinese people normal blood lipid levels. In our study, aimed analyze population without dyslipidemia.In retrospective cohort 9838 subjects who were free...
Abstract Background The relationship of cumulative remnant-cholesterol (Cum-RC) concentration with the risk cardiovascular disease (CVD) in patients hypertension remains unclear. Methods We studied data for 28,698 individuals whom three consecutive total cholesterol, high-density lipoprotein-cholesterol (HDL-C), and triglyceride concentrations were available, who did not have CVD (14,349 14,349 without), that was collected between 2006 2010. Participants placed into four groups based on...
In 2010 the American Heart Association proposed a definition of ideal health behaviors and factors to measure cardiovascular health, from which Huffman et al. created Cardiovascular Health Score (CVH score) estimate these metrics on an individual level. We performed prospective cohort study among employees Kailuan Group Corporation, who underwent physical examination in 2006–2007 investigate relationship between CVH score risk disease (CVD). A total 91,598 individuals free stroke myocardial...
A higher ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is considered as the independent risk index cardiovascular (CV) events. However, cohort studies regarding this correlation are rarely reported, especially in Chinese population. The aim present study was explore relationship TG/HDL-C with CV risks among adults during 10-year follow-up period.
The aim of this study was to examine the association between age at onset overweight and incident hypertension.We analysed 4742 participants with new-onset from Kailuan 2006 2015 age-matched sex-matched controls selected randomly same cohort but normal weight. Participants were compared respect subsequent risk hypertension, sub-HR calculated Fine Gray model, according overweight.Over a mean follow-up period 5.17 years, 1642 (34.6%) 1293 normal-weight (27.3%) subsequently diagnosed...
Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed investigate the age-specific risks of type 2 (T2D) upon concomitant chronic dyslipidemia.Age-stratified Cox regression analysis risk incident co-exposure time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) index plasma (CumAIP) among 42,925 nondiabetic participants from a...
BACKGROUND The aim of this study was to investigate the association between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) in hypertensive males. MATERIAL AND METHODS Altogether, 14 866 male participants were included analysis. Participants divided into 3 groups: low BMI group (BMI <24 kg/m²), moderate (24 kg/m² ≤BMI <28 high ≥28 kg/m²). According baPWV values, arteriosclerosis (AS) set as degrees: mild AS (baPWV ≥1400 cm/s), ≥1700 cm/s) severe ≥2000 cm/s). Multivariate...
Abstract Background Hypertension is currently the leading modifiable cause of global morbidity and mortality, to substantial health financial burdens. Although multiple studies management models innovative therapeutic strategies for hypertension have been conducted, there are still gaps in field, with a poor control rate reflecting lack novel, effective, clinically translated medication or intervention options. Recent animal human repeatedly confirmed link between microbiota hypertension. Of...
The atherogenic index of plasma (AIP) has been shown to be positively correlated with cardiovascular events. However, it remains unclear whether hypertensive patients long-term high AIP levels are at greater risk developing heart failure (HF). Therefore, the aim this study was investigate association between trajectory and incidence HF in patients. This prospective included 22,201 from Kailuan Study who underwent three waves surveys 2006 2010. Participants were free or cancer before during...
Obesity and overweight are related to changes in blood pressure, but existing research has mainly focused on the impact of body mass index (BMI) short-term pressure variability (BPV). The study aimed examine BMI long-term BPV. Participants Kailuan who attended all five annual physical examinations 2006, 2008, 2010, 2012, 2014 were selected as observation subjects. In total, 32,482 cases included statistical analysis. According definition obesity China, was divided into four groups:...
Abstract On the basis of 45,092 participants (mean age 54.04 ± 13.09 years) from Kailuan study, this study was performed to explore relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) quantify their separate effects. The correlations TC, SBP, BaPWV were analyzed using multivariate linear regression models. Mediation analysis determine whether effect TC on SBP can be explained by arterial stiffness. Multivariate showed that...
Background Metabolic syndrome (MetS) is associated with an increased risk of incident cardiovascular diseases (CVD), but the association between new-onset MetS at different ages and CVD remain unclear. Methods This was a prospective study comprising total 72,986 participants without who participated in Kailuan baseline survey (July 2006 to October 2007). All received biennial follow-up visit until December 31, 2019. In addition, 26,411 patients were identified from follow-up, one control...
Abstract Background Concurrent insulin resistance and elevated blood pressure are commonly observed in cardiovascular disease (CVD) have long been proposed to contribute CVD. However, the temporal relationship between them effect of their cumulative co-exposure on future incident CVD remains unclear. Methods Longitudinal analysis data 57,192 participants from a real-world, prospective cohort study (Kailuan Study) was performed address Triglyceride-Glucose Index (TyG, calculated as ln [TG...
Abstract Aim Previous reports found positive associations between RBC traits (RBC count and hemoglobin) hypertension, but their individual joint effects on new-onset hypertension by sex are unclear. Methods This longitudinal study involved 51,663 adults from the Kailuan Cohort. We utilized weighted Cox regression models to evaluate of hemoglobin sex. Restricted cubic splines Kaplan-Meier curves were employed nonlinear relationships depict differential survival probabilities, respectively....
Metabolic syndrome (MetS) is an important criterion for clinicians in assessing cardio-kidney-metabolic diseases, yet the association between longitudinal evolution of MetS and disease multimorbidity remains unclear. The purpose this study was to investigate extent increased risk individuals recovered from mediation Life's Essential 8 (LE8) score on transition patterns multimorbidity. A cohort using data Kailuan (2006-2010) conducted. Cox regression models were used assess with its...
The association between changes in cardiovascular health score (CHS) over time and myocardial infarction (MI) risk hypertensive patients remains unclear.This was a prospective study comprising 17 374 from the Kailuan cohort who underwent 3 surveys were identified to be free of MI, stroke, or cancer 2006 2010. CHS consisted 7 metrics (plasma glucose, total cholesterol, blood pressure, smoking, body mass index, physical activity, salt intake), ranging 0 (worst) 13 (best) study. trajectories...