Lung cancer, a deadly malignancy, often employs Docetaxel (DTX) as chemotherapy option. However, DTX non-selective distribution limits its therapeutic effectiveness due to adverse side effects. This study aims develop novel folate-targeted albumin polyester nanocarriers (FA-DTX-APs) encapsulating for precise delivery, enhancing lung cancer treatment efficacy. FA-DTX-APs were meticulously crafted utilizing the thin-film dispersion technique and subsequently evaluated their physicochemical...

Abstract Background Effective methods to deliver therapeutic genes solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development efficient non-viral vector with tumor-targeting has very important application value in field cancer Proteolipid integrated potential functional protein excellent delivery performance shown for targeted Results Herein, we prepared transferrin-modified liposomes (Tf-PL) acetylcholinesterase (AChE)...

Aims The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) pancreatic cancer (PC) is known, however, its mechanism unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand by identifying Gli1 targets cells. Methods First, investigated invasion, migration, and EMT PC cells transfected with lentiviral interference vectors or over-expression vitro vivo. Next, determined the target gene profiles using cDNA microarray assays....

We aimed to evaluate the efficacy and safety of oxaliplatin, 5-fluorouracil (5-FU), leucovorin (LV) (FOLFOX-4) as second-line treatment in patients with advanced biliary tract cancer (BTC) failing gemcitabine/cisplatin first-line chemotherapy.Thirty-seven BTC refractory chemotherapy were included study. FOLFOX-4 regimen consisted oxaliplatin (85 mg/m(2)) a 2-hour infusion on day 1 LV (200 mg/m(2)/day) followed by 5-FU bolus (400 22-hour (600 for two consecutive days every 2 weeks. The...

Dickkopf-related protein 4 (DKK4) is a target of the β-catenin/transcription factor complex in colorectal cancer. Previous research has demonstrated that its expression level may vary and indicated it have role development resistance to chemotherapy cancer cells. In present study, DKK4 was over expressed several cell lines. The over-expressing lines were screened using reverse transcription quantitative polymerase chain reaction analysis western blotting. Analysis viability control lines,...

The accuracy and efficiency are hardly acquired together in most wear analysis methods. Especially, the effect of contact stiffness is rarely considered process. Therefore, a method clearance joint considering presented. Massless link spring damping (MLSD) model used to conduct dynamic system stiffness. nonsymmetric Winkler surface taken compute pressure distribution. Archard theory adopted calculate amount surface. contour changes with calculation results over time. Then, trend acquired....

The Hh (hedgehog) signaling pathway is still waiting for further studies because its downstream molecular mechanism remains elusive. Because EIF5A2 (eukaryotic translation initiation factor 5A2) gene was up-regulated upon Gli1 (GLI family zinc finger 1) in pancreatic cancer (PC) cells, we speculated that this might promote tumor progression through regulating EIF5A2.We investigated regulation effect of to transcription by knockdown or overexpression PC cell lines first. Then, the studied at...

In order to standardize the design process of complex products and improve customer satisfaction intelligence specific scheme, a case Lower Limb Exoskeleton Rehabilitation Robot (LLERR) is presented in this paper. Under precondition that walk assistance rehabilitation training functions are achieved, higher demands for LLERR from psychological physiological needs users proposed. Based on research status market robots, conceptual with character customized gait exoskeleton presented. The...

In this paper, the material removal mechanism of copper chemical mechanical polishing was studied by quasicontinuum method that integrated molecular dynamics and finite element method. By analyzing abrasive process different particle sizes on single crystal copper, we investigated internal deformation, formation chips, stress distribution, change cutting force. Results showed shear band deformation generated along direction at approximately 45° inside workpiece material. The accompanied...

Under the precondition that walk assistance and rehabilitation functions are achieved, higher demands for lower limb exoskeleton robot from psychological physiological needs of users proposed. Based on analysis research status robots, Quality Function Deployment (QFD) method is adopted to conduct demand analysis, define design requirement make decision. A with character customized gait presented in this paper. Then, order standardize process improve customer satisfaction intelligence...

Background. Uveal Melanoma (UM) is a potentially lethal cancer, and epigenetics may participate in the regulation of MEK resistance. This study aimed at targeting epigenetic kinase to overcome resistance inhibitor. Method. We developed 92.1 OMM1 MEK-inhibitor resistant cell lines by culturing them trametinib (Tra) mixed medium. utilized CCK8 analysis for detecting viability cell. Western blot was used determine ERK1/2 Akt phosphorylation. Small compound library screening assays were carried...

Abstract With the proposal of “Double-Carbon” goal and acceleration energy transformation, a large number distributed new sources such as photovoltaics wind power, are connected to power distribution system, system has developed into novel with optimization coordination its core, thus put forward higher requirements for safety protection network. However, when line network is repaired or faulty, very easy cause islanding effect. Measures anti-islanding still implemented based on...

Chenopodium ambrosioides L. is an invasive plant native to the Neotropics that has seriously threatened ecological security of China, and allelopathy one mechanisms underlying its successful invasion. Maize (Zea mays L.) soybean (Glycine max (L.) Merr.), as main food crops, are usually affected by C. in their planting areas. The purpose this study was investigate ultrastructure, autophagy, release-related gene expression receptor root border cells (RBCs) after exposure volatile oil from...

PurposeThis study aimed to detect the role and mechanism of circTMEM59 in pancreatic ductal adenocarcinoma (PDAC).Methods66 paired PDAC tissues normal samples were harvested from patients diagnosed undergoing cancer surgery our hospital. The expression cell lines was detected. Based on bioinformatics information, mimics, miR-147b inhibitor si-suppressor cytokine signaling 1 (SOCS1) transfected into cells. levels circTMEM59, SOCS1 detected by quantitative real-time polymerase chain reaction...

The objective of this study was to prepare doxorubicin-loaded EGF modified PEG-nanoparticles and evaluate its targeting capability therapeutic effects with EGFR-expressing hepatocellular carcinoma cells. morphology, particle size distribution, doxorubicin content the nanoparticles were measured, drug loading encapsulation efficiency calculated. prepared regular circular, good dispersibility, no adhesion, average (136.7±9.3) nm. (76.67±8.63)%, (3.86±0.55)%; release rate 100% for 12 h,...

Abstract Effective methods to deliver therapeutic genes solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development efficient non-viral vector with tumor-targeting has very important application value in field cancer Proteolipid integrated potential functional protein excellent delivery performance shown for targeted Results: Herein, we prepared t ransferrin-modified liposomes (Tf-PL) acetylcholinesterase (AChE) liver...

Purpose Because of the various geometric descriptions different bearing types, performance calculation journal is complicated, and difficult in traditional model. This paper aims to simplify performance, reduce workload. Design/methodology/approach On basis previous research, a general model proposed this paper. Eccentricity ratio attitude angle axis each pad are calculated by coordinates spindle center establishing unified coordinate system. The surface deformation taken into consideration,...

The reliable operation of the shore power supply system greatly affects entire system. However, due to complex topological structure system, changeable mode, and numerous lines, fault detection is difficult. correct rate line selection various devices currently used not high. This paper proposes a single-phase-to-ground data driven method for small-current grounding systems based on big data. First, algorithm accesses stores related failure onshore raw processed into feature using...

Abstract Due to the complex environmental conditions of inland ports, it is great significance adopt associated protection ensure safe and reliable operation shore-to-ship power supply system. To accurately simulate operating system, simulation model ship system established completely. According characteristics port, shore-based designed established. Based on a low voltage meet its requirements it, an method including safety interlock, under-voltage protection, short-circuit proposed. verify...