Rosalind Ramsey‐Goldman
A5010072602- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- Complement system in diseases
- Peripheral Neuropathies and Disorders
- Liver Diseases and Immunity
- Reproductive System and Pregnancy
- Drug-Induced Ocular Toxicity
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Adrenal Hormones and Disorders
- Eosinophilic Disorders and Syndromes
- Celiac Disease Research and Management
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
Northwestern University
2016-2025
Northwestern Medicine
2023-2024
University of North Carolina at Chapel Hill
2007-2023
University of Mississippi Medical Center
2006-2023
Lupus Research Alliance
2023
Columbia University
2023
KDH Research & Communication (United States)
2023
Emory University
2023
Center for Rheumatology
2007-2019
NIHR Manchester Biomedical Research Centre
2019
The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, incorporate new knowledge regarding immunology SLE.The were derived from a set 702 expert-rated patient scenarios. Recursive partitioning was used derive an initial rule that simplified refined based on SLICC physician...
Abstract Clinical criteria for the classification of patients with hip pain associated osteoarthritis (OA) were developed through a multicenter study. Data from 201 who had experienced most days prior month analyzed. The comparison group other causes pain, such as rheumatoid arthritis or spondylarthropathy. Variables medical history, physical examination, laboratory tests, and radiographs used to develop different sets serve investigative purposes. Multivariate methods included traditional...
To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR).This international initiative had four phases. 1) Evaluation antinuclear antibody (ANA) as an entry criterion through systematic review meta-regression literature generation Delphi exercise, early patient cohort, a survey. 2) Criteria reduction nominal group technique exercises. 3) definition weighting...
Abstract Objective To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. Methods Our sample was a multisite international SLE (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized ratio (SMR; of deaths observed to expected) estimates calculated for all and cause. The effects sex, age, duration, race, calendar‐year periods determined. Results overall SMR 2.4 (95% confidence interval 2.3–2.5)....
Abstract Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis (OA) hands were developed from data collected in a multi‐center study. Patients with OA compared group patients who had hand symptoms other causes, such as rheumatoid arthritis and spondylar‐thropathies. Variables medical history, physical examination, laboratory tests, radiographs analyzed. All pain, aching, or stiffness hands. classified having clinical if on examination there was hard...
We investigated the role of costimulatory molecules, CD40 and its ligand CD40L, in pathogenesis human SLE. In comparison to normal subjects or patients remission, PBMC from active lupus had a 21-fold increase frequency CD40L-expressing, CD4+T cells. However, expression CD40L induced either T cells by mitogenic stimulation could be down-regulated equally well molecules on autologous B Active also 22-fold percentage CD8+ expressing consistent with their unusual helper activity Surprisingly,...
Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. Methods. Patients the Systemic Lupus International Collaborating Clinics cohort (≤15 months of diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality life was measured by Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental physical component summary scores. Results....
Allelic variants of Fc gamma R confer distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Human RIIa has two codominantly expressed alleles, R131 and H131, which differ substantially in their ability ligate human IgG2. The RIIa-H131 is the only recognizes IgG2 efficiently optimal handling occurs homozygous state. Therefore, since clearance essential SLE, we hypothesized that RIIA genes are important disease factors particularly lupus...
<h3>Background and aims</h3> We studied damage accrual factors determining development progression of in an international cohort systemic lupus erythematosus (SLE) patients. <h3>Methods</h3> The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months developing four or more 1997 American College Rheumatology (ACR) criteria for SLE; the SLICC/ACR index (SDI) was measured annually. assessed relative rates transition using maximum...
Abstract Objective. To examine racial differences in the incidence of systemic lupus erythematosus (SLE). Methods. A population‐based registry SLE patients Allegheny County, Pennsylvania, was used to identify incident cases diagnosed between January 1, 1985 and December 31, 1990, from 3 sources, by medical record review (University Pittsburgh Lupus Databank, rheumatologists, hospitals). Capture‐recapture methods using log‐linear models were estimate level case‐finding calculate 95%...
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals European (EA), African (AA) Hispanic Amerindian (HA) ancestry. identify 58 distinct non-HLA regions in EA, 9 AA 16 HA (∼50% these have multiple independent associations); include 24 novel (P<5 × 10-8), refined signals established regions, extended associations to additional...
Abstract Objective There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but earlier studies the could not be quantified precisely. The present study was undertaken to ascertain incidence cancer SLE patients, compared with that general population. Methods We assembled a multisite (23 centers) international cohort patients diagnosed as having SLE. Patients at each center were linked regional tumor registries determine occurrence....
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events impact on quality life over 3 years in a large inception cohort patients with systemic lupus erythematosus (SLE). Methods The study was conducted by Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months SLE diagnosis. NP identified using American College Rheumatology case definitions, decision rules derived to proportion disease attributable SLE....
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN more prevalent among African Americans than European Americans. This study was undertaken investigate the hypothesis apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in rare Americans, contribute ethnic disparity risk.APOL1 G1 G2 were genotyped 855 American SLE patients with LN-ESRD (cases) 534...
To estimate the incidence of juvenile dermatomyositis (juvenile DM) in United States between 1995 and 1998.Physician referrals to National Institute Arthritis Musculoskeletal Skin Diseases Juvenile Dermatomyositis Research Registry Pediatric Rheumatology Disease from Indiana University were utilized for a 2-source capture-recapture estimation DM annual incidence.For children 2-17 years age, estimated rates 1998 US ranged 2.5 4.1 cases per million children, 4-year average rate was 3.2 (95%...
To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort systemic lupus erythematosus (SLE) patients.The study was conducted by Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months fulfilling American College Rheumatology (ACR) SLE classification criteria. All NP a predefined enrollment window identified using ACR case definitions 19 syndromes....
Abstract The success of organ transplantation is related to advances in immunosuppressive therapy. These medications are associated with medical complications including bone damage. objective this study was estimate and compare age, gender-specific fracture incidence between transplant recipients, a large sample representative the civilian noninstitutionalized United States population using 1994 National Health Interview Survey (NHIS). This cohort set tertiary care centers. Five hundred...
A combined forward and reverse genetic approach was undertaken to test the candidacy of IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor for systemic lupus erythematosus (SLE). In studying approximately 5,000 subjects healthy controls, 5 SNPs spanning gene showed disease association (P values reaching 10(-10), odds ratio >1.5) in both adult- childhood-onset SLE, 4 different ethnic groups, with a SNP haplotype (GGGG) being strongly disease. The...
The goal of this work was to develop an economical way tracking disease activity for large groups systemic lupus erythematosus (SLE) patients in clinical studies. A Systemic Lupus Activity Questionnaire (SLAQ) developed screen possible using items from the Measure (SLAM) and tested its measurement properties. SLAQ completed by 93 SLE just prior a scheduled visit. At visit, rheumatologist, blinded results, examined subject SLAM. Associations among SLAQ, SLAM (omitting laboratory items)...