Elizabeth E. Brown
A5103052642- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- T-cell and Retrovirus Studies
- Cytomegalovirus and herpesvirus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Rheumatoid Arthritis Research and Therapies
- Glycosylation and Glycoproteins Research
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Galectins and Cancer Biology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
University of Alabama at Birmingham
2015-2024
University of Alabama
2010-2024
Northwestern University
2023-2024
Shirley Ryan AbilityLab
2023
O'Neal Comprehensive Cancer Center
2022
Medical University of South Carolina
2013
Oregon Health & Science University
1993-2013
Animal Health Trust
2011
St. Vincent's Birmingham
2010
National Institutes of Health
2005-2008
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals European (EA), African (AA) Hispanic Amerindian (HA) ancestry. identify 58 distinct non-HLA regions in EA, 9 AA 16 HA (∼50% these have multiple independent associations); include 24 novel (P<5 × 10-8), refined signals established regions, extended associations to additional...
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN more prevalent among African Americans than European Americans. This study was undertaken investigate the hypothesis apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in rare Americans, contribute ethnic disparity risk.APOL1 G1 G2 were genotyped 855 American SLE patients with LN-ESRD (cases) 534...
Prior improvements in multiple myeloma (MM) survival were not fully observed racial and ethnic minorities older individuals. We hypothesized that MM management recent years have reduced these disparities. used the Surveillance, Epidemiology, End Results registries to calculate incidence relative rates (RSRs) of United States for patients diagnosed from 1993 1997 (prethalidomide), 1998 2002 (introduction thalidomide), 2003 2007 (bortezomib lenalidomide), 2008 2012 (upfront bortezomib...
The heparan sulfate-degrading enzyme heparanase promotes the progression of many cancers by driving tumor cell proliferation, metastasis and angiogenesis. Heparanase accomplishes this via multiple mechanisms including its recently described effect on enhancing biogenesis exosomes. Because we discovered that expression is upregulated in myeloma cells survive chemotherapy, were prompted to investigate impact anti-myeloma drugs exosome biogenesis. When exposed commonly utilized bortezomib,...
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been multiple human diseases may contribute dysregulated activation predisposing SLE. We assessed 60 SNPs covering CFH-CFHRs region for association SLE in 15,864 case-control subjects derived from four ethnic groups....
Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. demonstrates familial aggregation accounts for significant morbidity mortality. We completed meta-analysis three genome-wide association studies to identify lupus nephritis-predisposing loci. Through genotyping imputation, >1.6 million markers were assessed in 2000 unrelated women European descent with (588 patients 1412 without nephritis). Tests computed using logistic regression...
Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease. A number of genetic loci that increase susceptibility have been established. This study examines if these also contribute to the clinical heterogeneity in lupus.
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with a strong genetic component. African-Americans (AA) are at increased risk of SLE, but the basis this largely unknown. To identify causal variants in SLE loci AA, we performed admixture mapping followed by fine AA and European-Americans (EA). Through genome-wide identified susceptibility locus 2q22–24 (LOD = 6.28), signal associated European ancestry (ancestry ratio ∼1.5). Large-scale genotypic analysis on 19,726...
We previously reported that the G allele of rs3853839 at 3′untranslated region (UTR) Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6.5×10−10, odds ratio (OR) (95%CI) 1.27 (1.17–1.36)]. Here, we conducted trans-ancestral fine-mapping 13,339 subjects including European Americans, African Amerindian/Hispanics confirmed as only variant within TLR7-TLR8 exhibiting consistent...
Abstract Objective Candidate gene and genome‐wide association studies have identified several disease susceptibility loci in lupus patients. These largely been performed patients who are Asian or of European ancestry. This study was undertaken to examine whether some these same increase risk African American individuals. Methods Single‐nucleotide polymorphisms tagging 15 independent were genotyped a set 1,724 2,024 healthy controls descent. The examined included PTPN22 , FCGR2A TNFSF4 STAT4...
This study examined the efficacy of C.E.R.A., a continuous erythropoietin receptor activator, for correcting anemia in patients who had chronic kidney disease (CKD) and were not on dialysis.In this open-label, randomized, parallel-group, Phase III study, 324 adult with CKD dialysis nor receiving treatment erythropoiesis-stimulating agents (ESAs) randomly assigned (1:1) to receive subcutaneous C.E.R.A. once every 2 wk or darbepoetin alfa weekly during an 18-wk correction period 10-wk...
Objectives Systemic lupus erythematosus (SLE) is a sexually dimorphic autoimmune disease which more common in women, but affected men often experience severe disease. The genetic basis of sexual dimorphism SLE not clearly defined. A study was undertaken to examine sex-specific effects among susceptibility loci. Methods total 18 autosomal loci for were genotyped large set patients with and controls European descent, consisting 5932 female 1495 male samples. Sex-specific association analyses...
<h3>Objectives</h3> The Xq28 region containing <i>IRAK1</i> and <i>MECP2</i> has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between <i>MECP2</i>, it remains unclear which gene is affected by underlying causal variant(s) conferring of SLE. <h3>Methods</h3> We fine-mapped ≥136 SNPs ∼227 kb on Xq28, <i>IRAK1, MECP2</i> seven adjacent genes (<i>L1CAM, AVPR2, ARHGAP4, NAA10,...
American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) a higher prevalence of nephritis than do Caucasians. The aim this study was to analyze the relationship between genetic ancestry sociodemographic characteristics clinical features in large cohort Indian-European SLE patients.A total 2,116 patients origin 4,001 European descent for whom we had data were included study. Genotyping 253 continental ancestry-informative...
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-κB is involved. We reported previously a knockin mouse expressing an inactive form ABIN1 (ABIN1[D485N]) develops lupus-like autoimmune disease and demonstrates enhanced activation NF-κB mitogen-activated protein kinases in immune cells after toll-like receptor stimulation. In current study, we show...
Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian frequentist approaches to model the IRF5–TNPO3 locus association, now implicated in two immunotherapies seven autoimmune diseases. Specifically, systemic lupus erythematosus (SLE), resolved separate associations IRF5 promoter (all ancestries) with an extended European haplotype. We captured 3230 high-quality, common variants across 5 ethnicities 8395 SLE cases 7367 controls. The genetic effect...
BACKGROUND Recent advances in the treatment of multiple myeloma (MM) have been associated with improved survival, predominantly among young and white patients. The authors hypothesized that sociodemographic factors, adjusted for race/ethnicity, influence survival younger patients MM. METHODS Overall (OS) data were obtained individuals included Surveillance, Epidemiology, End Results (SEER‐18) program who diagnosed MM before age 65 years between 2007 2012. variables addressed marital status,...