Olga Y. Gorlova
A5077624751- Genetic Associations and Epidemiology
- Systemic Sclerosis and Related Diseases
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Bioinformatics and Genomic Networks
- Celiac Disease Research and Management
- Molecular Biology Techniques and Applications
- Evolution and Genetic Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Systemic Lupus Erythematosus Research
- Genetic Syndromes and Imprinting
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
Baylor College of Medicine
2011-2025
Houston Institute for Clinical Research
2020-2024
Dartmouth College
2013-2023
Dartmouth–Hitchcock Medical Center
2015-2022
The University of Texas MD Anderson Cancer Center
2005-2020
Vitebsk State Academy of Veterinary Medicine
2019
Moscow Institute of Physics and Technology
2014
Cotton (United States)
2013
Feinstein Institute for Medical Research
2012
Brown Foundation
2012
The aim of this study was to determine, through a genome-wide association (GWAS), the genetic components contributing different clinical sub-phenotypes systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous involvement, relationships with presence SSc-specific auto-antibodies, anti-centromere (ACA), anti-topoisomerase I (ATA). Four GWAS cohorts, comprising 2,296 SSc patients 5,171 healthy controls, were meta-analyzed looking for associations in selected...
BackgroundConsiderable effort has been expended on tobacco control strategies in the United States since mid-1950s. However, we have little quantitative information how changes smoking behaviors impacted lung cancer mortality. We quantified cumulative impact of that started mid-1950s mortality over period 1975–2000.
<h3>Objective</h3> The first genome-wide association study (GWAS) of systemic sclerosis (SSc) demonstrated three non-major histocompatibility complex (MHC) susceptibility loci. goal this was to investigate the impact these gene variants on survival and severity interstitial lung disease (ILD) in SSc. <h3>Methods</h3> authors examined 1443 Caucasian SSc patients enrolled <b><i>G</i></b>enetics versus <b><i>E</i></b>nvironment <b><i>I</i></b>n <b><i>S</i></b>cleroderma <b><i>O</i></b>utcome...
Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian frequentist approaches to model the IRF5–TNPO3 locus association, now implicated in two immunotherapies seven autoimmune diseases. Specifically, systemic lupus erythematosus (SLE), resolved separate associations IRF5 promoter (all ancestries) with an extended European haplotype. We captured 3230 high-quality, common variants across 5 ethnicities 8395 SLE cases 7367 controls. The genetic effect...
A single-nucleotide polymorphism (SNP) at the IL12RB2 locus showed a suggestive association signal in previously published genome-wide study (GWAS) systemic sclerosis (SSc). Aiming to reveal possible implication of gene SSc, we conducted follow-up this different Caucasian cohorts. We analyzed 10 GWAS-genotyped SNPs region (2309 SSc patients and 5161 controls). then selected three (rs3790567, rs3790566 rs924080) based on their significance level GWAS, for an independent European cohort...
The existence of introns in eukaryotic genes is believed to provide an evolutionary advantage by increasing protein diversity through exon shuffling and alternative splicing. However, this feature associated with the necessity exclusion intronic sequences, which requires considerable energy expenditure can lead splicing errors. relationship between burden evolution poorly understood. goal study was analyze level conservation gene.We found a positive correlation gene its burden. estimated...
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, pathogenic pathways, through which SNPs within affects cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and expression quantitative trait loci (eQTL) on 409 to identify validate underlying pathways investigate combined effect of genes from pathways. The KEGG neuroactive ligand receptor...
Abstract We performed an analysis of potential epidemiological risk factors for lung cancer using data from 280 cases and 242 hospital‐based controls, all lifetime never smokers (those who had smoked <100 cigarettes in their lifetimes) frequency matched on age, gender ethnicity. The demographic characteristics, medical history respiratory diseases (asthma, emphysema, pneumonia hay fever), weight height, family history, female characteristics environmental tobacco smoke (ETS) dust exposure...
Abstract The authors evaluated the familial aggregation of lung and other cancers in first‐degree relatives cancer patients self‐reported to be lifetime never smokers. data, derived from a large case–control study, included 2,465 316 smoker cases 2,441 318 controls, frequency matched on age, gender ethnicity. median age controls was 61 years, about 2/3 were women, 80% Caucasian. Overall, there 25% excess risk [95% CI (1.05–1.50)] any type among cases, case offspring exhibited 2‐fold...
<h3>Introduction</h3> A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (<i>PSORS1C1</i>, <i>TNIP1</i> and <i>RHOB</i>) as novel genetic risk factors for the disease. The aim of this was to replicate previously mentioned findings a large multicentre independent SSc cohort Caucasian ancestry. <h3>Methods</h3> 4389 7611 healthy controls from different countries USA were included study. Six single nucleotide polymorphisms (SNP): rs342070,...
Evidence from human and animal research indicates that choline metabolic pathways may be activated during a variety of diseases, including cancer. We report results case-control study 2821 lung cancer cases 2923 controls assessed associations betaine dietary intakes with Using multivariable logistic regression analyses, we significant association between higher intake lower risk varied by smoking status. Specifically, no was observed among never-smokers. However, significantly associated...
Suboptimal cellular DNA repair capacity (DRC) has been shown to be associated with enhanced cancer risk, but genetic variants affecting the DRC phenotype have not comprehensively investigated. In this study, available data, we analyzed correlations between and genotypes detected by Illumina 317K platform in 1,774 individuals of European ancestry from a Texas lung genome-wide association study. The discovery phase was followed replication an independent set 1,374 cases controls ancestry. We...
Abstract Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals European ancestry and investigated gene expression levels in 7,773 samples. find a large-effect association with an ATM L2307F (rs56009889) mutation adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P 1.18 × 10 −15 ) replication OR 2.93, 2.22 −3 that is more pronounced females 6.81 3.19 replication). observe excess loss heterozygosity tumors among...
Objectives It is significant to know how much early detection and screening could reduce the proportion of occult metastases benefit NSCLC patients. Methods We used previously designed validated mathematical models obtain characteristics LC in population including undetectable at time diagnosis. The survival was simulated using functions from Surveillance, Epidemiology End Results (SEER) data stratified by stage. Based on simulations, 35.3% patients diagnosed with stage N0M0 56.9% those N1M0...