A5010220689- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Intimate Partner and Family Violence
- Sexual Assault and Victimization Studies
- Lung Cancer Treatments and Mutations
- Child Abuse and Trauma
- Childhood Cancer Survivors' Quality of Life
- Genetic factors in colorectal cancer
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Surgical Treatments
- Cancer survivorship and care
- Prostate Cancer Treatment and Research
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Asthma and respiratory diseases
- Palliative Care and End-of-Life Issues
- Criminal Justice and Corrections Analysis
- Gastric Cancer Management and Outcomes
Harvard University
2011-2023
Harvard Pilgrim Health Care
2019-2023
Lancashire Teaching Hospitals NHS Foundation Trust
2021-2022
Our Lady of the Lake Children's Hospital
2012-2021
Our Lady of the Lake Regional Medical Center
2013-2019
Massachusetts General Hospital
2008-2017
Dana-Farber Cancer Institute
2008-2015
University of California, Los Angeles
2012-2015
University of Colorado Denver
2014
Duke Medical Center
2014
The optimum screening policy for lung cancer is unknown.
In the United States, 192,000 men were diagnosed as having prostate cancer in 2009, majority with low-risk, clinically localized disease. Treatment of these cancers is associated substantial morbidity. Active surveillance an alternative to initial treatment, but long-term outcomes and effect on quality life have not been well characterized.To examine quality-of-life benefits risks active compared treatment for cancer.Decision analysis using a simulation model was performed: treated at...
This study analyzed data from the 1995 National College Health Risk Behavior Survey (NCHRBS) to assess prevalence of lifetime rape among female college students and examine association between health-risk behaviors. The NCHRBS used a mail questionnaire behaviors nationally representative sample undergraduate students. Twenty percent reported ever having been forced have sexual intercourse, most often during adolescence. When analyses controlled for demographic characteristics, who had raped...
BACKGROUND Well‐differentiated thyroid cancer (WDTC) is a prevalent disease, which increasing in incidence faster than any other cancer. Substantial direct medical care costs are related to the diagnosis and treatment of newly diagnosed patients as well ongoing surveillance who have long life expectancy. Prior analyses aggregate health attributable WDTC United States not been reported. METHODS A stacked cohort cost analysis was performed on US population from 1985 2013 estimate number...
BackgroundConsiderable effort has been expended on tobacco control strategies in the United States since mid-1950s. However, we have little quantitative information how changes smoking behaviors impacted lung cancer mortality. We quantified cumulative impact of that started mid-1950s mortality over period 1975–2000.
Abstract BACKGROUND: Although breast cancer screening with mammography and magnetic resonance imaging (MRI) is recommended for cancer‐susceptibility gene (BRCA) mutation carriers, there no current consensus on the optimal regimen. METHODS: The authors used a computer simulation model to compare 6 annual strategies (film [FM], digital [DM], FM [MRI] or DM MRI contemporaneously, alternating FM/MRI DM/MRI at 6‐month intervals) beginning ages 25 years, 30 35 40 2 of delayed DM/FM versus clinical...
Chinese translation Background: Observation is underutilized among men with localized, low-risk prostate cancer. Objective: To assess the costs and benefits of observation versus initial treatment. Design: Decision analysis simulating treatment or observation. Data Sources: Medicare schedules, published literature. Target Population: Men aged 65 75 years who had newly diagnosed cancer (prostate-specific antigen level <10 µg/L, stage ≤T2a, Gleason score ≤3 + 3). Time Horizon: Lifetime....
The questionnaire included: ■Demographic items (age, race/ethnicity, parent's educational level...) ■Questions related to risk taking behaviors (physical fighting, cigarette smoking, marijuana use, episodic heavy drinking, driving under the influence of alcohol, multiple concurrent sexual partners, and suicidal ideation) ...AND ■The question: During your life, have you ever been forced intercourse against will?”
To use individual-level data provided from the single-arm study of helical computed tomographic (CT) screening at Mayo Clinic (Rochester, Minn) to estimate long-term effectiveness in participants and compare estimates an existing lung cancer simulation model with a different modeling approach that used same data.The was approved by institutional review boards HIPAA compliant. Deidentified (1520 current or former smokers aged 50-85 years) CT were populate Lung Cancer Policy Model,...
Abstract BACKGROUND: Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women susceptibility gene ( BRCA ) mutations. Unspecified details of schedules are a challenge implementing guidelines. METHODS: A Markov Monte Carlo computer model was used to simulate in asymptomatic who were BRCA1 BRCA2 mutation carriers. Three dual‐modality strategies compared digital (DM) alone: 1) DM MRI alternating at...
BACKGROUND The National Lung Screening Trial (NLST) demonstrated that low‐dose computed tomography screening is an effective way of reducing lung cancer (LC) mortality. However, optimal strategies have not been determined to date and it uncertain whether lighter smokers than those examined in the NLST may also benefit from screening. To address these questions, necessary first develop LC natural history models can reproduce outcomes simulate programs at population level. METHODS Five...
Background: Several trials have shown that integrated palliative and oncology care improves quality of life mood in patients with advanced cancers. However, the degree to which early involvement (PC) outpatient setting impacts cost remains unknown. Methods: Data for this secondary analysis came from a trial 151 metastatic nonsmall-cell lung cancer (NSCLC) who were randomized PC standard (SC) or SC alone. We abstracted costs hospital care, including intravenous chemotherapy, accounting...
An exploratory, qualitative study generated hypotheses about women in violent heterosexual relationships: reasons stay, what helps end the violence, barriers, potential early warning signs, resources, racial differences, and location differences. Twenty-two focus groups of urban rural African American White five U.S. regions were convened. Participants at least 18 years age, had experienced physical violence intimate relationships, been free for 6 months. Findings provide insights tangible...
The objective of our study was to prospectively determine how CT affects physicians' diagnostic certainty and management decisions in the setting patients with nontraumatic abdominal complaints presenting emergency department.We included 584 department from November 2006 through February 2008. Emergency clinicians were surveyed both before (pre-CT) after (post-CT) leading diagnosis, certainty, decisions. Changes assessed by Fisher's exact test log likelihood ratio.The most common diagnoses...
Purpose To evaluate the clinical effectiveness and cost-effectiveness of screening strategies in which MR imaging screen-film mammography were used, alone combination, women with BRCA1 mutations. Materials Methods Because this study did not involve primary data collection from individual patients, institutional review board approval was needed. By using a simulation model, we compared three annual for cohort 25-year-old mutation carriers, as follows: (a) mammography, (b) imaging, (c)...
This paper presents the public health approach to prevention of sexual violence. The addresses primary, secondary, and tertiary levels prevention. An explanation each level is given as it relates area Additionally, attempts shift focus from potential victims perpetrators. four steps model are presented with examples how Centers for Disease Control Prevention applying this violence