A5056536370- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Cleft Lip and Palate Research
- Family Support in Illness
- Craniofacial Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Hearing, Cochlea, Tinnitus, Genetics
- Economic and Financial Impacts of Cancer
- dental development and anomalies
- Language Development and Disorders
- Connective tissue disorders research
- Ear Surgery and Otitis Media
- Cancer Diagnosis and Treatment
- Noise Effects and Management
- Hearing Loss and Rehabilitation
- Head and Neck Surgical Oncology
- Multiple and Secondary Primary Cancers
- BRCA gene mutations in cancer
- Tracheal and airway disorders
- Cancer Treatment and Pharmacology
- Management of metastatic bone disease
- Patient Dignity and Privacy
- Neutropenia and Cancer Infections
- Global Cancer Incidence and Screening
Seattle Children's Hospital
2017-2025
University of Washington
2017-2025
Seattle Institute for Biomedical and Clinical Research
2025
Massachusetts General Hospital
2014-2024
University of Wisconsin–Madison
2023
Louisiana State University Health Sciences Center New Orleans
2022
Louisiana State University
2022
Mount Sinai Hospital
2020
Florida Craniofacial Institute
2019
Sylvester Comprehensive Cancer Center
2017-2018
Patients with metastatic non-small-cell lung cancer have a substantial symptom burden and may receive aggressive care at the end of life. We examined effect introducing palliative early after diagnosis on patient-reported outcomes end-of-life among ambulatory patients newly diagnosed disease.We randomly assigned to either integrated standard oncologic or alone. Quality life mood were assessed baseline 12 weeks use Functional Assessment Cancer Therapy-Lung (FACT-L) scale Hospital Anxiety...
Purpose We evaluated the impact of early integrated palliative care (PC) in patients with newly diagnosed lung and GI cancer. Patients Methods randomly assigned incurable or noncolorectal cancer to receive either PC oncology (n = 175) usual between May 2011 July 2015. who were intervention met a clinician at least once per month until death, whereas those received consulted upon request. The primary end point was change quality life (QOL) from baseline week 12, scoring by Functional...
Understanding of prognosis among terminally ill patients impacts medical decision making. The aims this study were to explore perceptions and goals therapy in with metastatic non-small-cell lung cancer (NSCLC) examine the effect early palliative care on these views over time.Patients newly diagnosed NSCLC randomly assigned receive either integrated standard oncology or alone. Participants completed baseline longitudinal assessments their a 6-month period.We enrolled 151 participants study....
Prior research shows that introducing palliative care soon after diagnosis for patients with metastatic non-small-cell lung cancer (NSCLC) is associated improvements in quality of life, mood, and survival. We sought to investigate whether early also affects the frequency timing chemotherapy use hospice these patients.This secondary analysis based on a randomized controlled trial 151 newly diagnosed NSCLC presenting an outpatient clinic at tertiary center from June 2006 July 2009....
BACKGROUND Early ambulatory palliative care (PC) is an emerging practice, and its key elements have not been defined. We conducted a qualitative analysis of data from randomized controlled trial that demonstrated improved quality life, mood, survival in patients with newly diagnosed metastatic non-small cell lung cancer who received early PC integrated standard oncologic vs alone. Our objectives were to (1) identify clinic visits, (2) explore the timing elements, (3) compare content visit...
Patients with incurable cancer face many physical and emotional stressors, yet little is known about their coping strategies or the relationship between strategies, quality of life (QOL), mood.As part a randomized trial palliative care, this study assessed baseline QOL (Functional Assessment Cancer Therapy-General), mood (Hospital Anxiety Depression Scale), (Brief COPE) in patients within 8 weeks diagnosis lung gastrointestinal before randomization. To examine associations QOL, mood, we used...
Purpose We describe the key elements of early palliative care (PC) across illness trajectory and examine whether visit content was associated with patient-reported outcomes end-of-life care. Methods performed a secondary analysis patients newly diagnosed advanced lung or noncolorectal GI cancer (N = 171) who were randomly assigned to receive PC. Participants attended at least monthly visits board-certified PC physicians practice nurses Massachusetts General Hospital. clinicians completed...
BACKGROUND Patients' perception of their prognosis has an impact on decisions about medical care. However, the relations between prognostic understanding and quality life (QoL) mood are unknown. The objectives this study were to assess perceptions preferences for information among patients with advanced cancer explore associations QoL mood. METHODS Fifty assessed within 6 12 weeks initiating chemotherapy gastrointestinal cancers. A 13‐item questionnaire was used patients' preferences, goal...
In a randomized trial, early palliative care (EPC) in patients with metastatic non-small-cell lung cancer (NSCLC) was observed to improve survival. secondary analysis, we explored the hypothesis that survival benefit resulted from improving depression.In total, 151 newly diagnosed NSCLC participated trial of EPC integrated standard oncology versus alone. Depression assessed at baseline and 12 weeks Patient Health Questionnaire-9 (PHQ-9) scored diagnostically by using Diagnostic Statistical...
Abstract Background Patients with advanced cancer often experience muscle wasting (sarcopenia), yet little is known about the characteristics associated sarcopenia and relationship between patients’ quality of life (QOL) mood. Materials Methods As part a randomized trial, we assessed baseline QOL (Functional Assessment Cancer Therapy-General [FACT-G]) mood (Hospital Anxiety Depression Scale [HADS]) in patients within 8 weeks diagnosis incurable lung or gastrointestinal cancer, prior to...
Purpose Patients' understanding of their illness is key for making informed treatment decisions, yet studies suggest an association between prognostic awareness and worse quality life (QOL) mood among patients with advanced cancer. We sought to explore the relationships awareness, coping, QOL, in newly diagnosed, incurable Methods assessed patients' self-reported health status goal (Prognosis Treatment Perceptions Questionnaire), coping (Brief COPE), QOL (Functional Assessment Cancer...
BACKGROUND We conducted a study to investigate the impact of hospitalization for hematopoietic stem cell transplantation (HCT) on quality life (QOL) and mood patients family caregivers (FC). METHODS longitudinal who were hospitalized HCT their FC. assessed QOL (using Functional Assessment Cancer Therapy‐Bone Marrow Transplantation) Hospital Anxiety Depression Scale) at baseline (6 days before HCT), day +1, +8 HCT. administered Medical Outcomes Study Health Survey Short Form‐36 examine FC...
The family and friends (caregivers) of patients with advanced cancer often experience tremendous distress. Although early integrated palliative care (PC) has been shown to improve patient-reported quality life (QOL) mood, its effects on caregivers' outcomes is currently unknown.
Purpose The early integration of oncology and palliative care (EIPC) improves quality life (QOL) mood for patients with advanced cancer. However, the mechanisms by which EIPC benefits these outcomes remain unclear. We therefore examined whether improved patients’ coping strategies if changes in accounted intervention effects on QOL depressive symptoms. Patients Methods For this secondary analysis an trial, we data from 350 newly diagnosed incurable lung or GI Participants completed...
BACKGROUND During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact this on patients' QOL posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS We conducted prospective longitudinal study hospitalized HCT. They assessed using Functional Assessment Cancer Therapy‐Bone Marrow Transplantation (FACT‐BMT) depression anxiety were Patient Health...
OBJECTIVE Universal hearing screening is essential for early identification of infants with loss, yet there a lack low-cost, scalable equipment suitable resource-constrained settings. Here we test low-cost smartphone device infant screening. METHODS Infants aged 0 to 6 months were recruited from 3 ambulatory clinics at Seattle Children’s Hospital high prevalence loss. We compared results open-source distortion product otoacoustic emission (OAE) probe and app commercially available OAE...
Background: Early palliative care provides better quality of life, increased prognostic awareness, and even improved survival for patients with advanced cancer but how the integrated model achieves these outcomes has not been completely explained. Methods: To understand clinical approach to early outpatient from clinicians' perspective, we conducted focus groups clinicians who had participated in a randomized trial metastatic lung cancer. Results: Clinicians described their role providing as...
Background: Several trials have shown that integrated palliative and oncology care improves quality of life mood in patients with advanced cancers. However, the degree to which early involvement (PC) outpatient setting impacts cost remains unknown. Methods: Data for this secondary analysis came from a trial 151 metastatic nonsmall-cell lung cancer (NSCLC) who were randomized PC standard (SC) or SC alone. We abstracted costs hospital care, including intravenous chemotherapy, accounting...
Background: Studies show that early, integrated palliative care (PC) improves quality of life (QoL) and end-of-life (EoL) for patients with poor-prognosis cancers. However, the optimal strategy delivering PC those advanced cancers who have longer disease trajectories, such as metastatic breast cancer (MBC), remains unknown. We tested effect a intervention on documentation EoL discussions, patient-reported outcomes, hospice utilization in this population. Patients Methods: MBC clinical...
Abstract Background. Studies demonstrate that early palliative care (EPC) improves advanced cancer patients’ quality of life (QOL) and mood. However, it remains unclear whether the role differs based upon demographic characteristics. We explored age gender moderate improvements in QOL mood seen with EPC. Methods. performed a secondary analysis data from randomized controlled trial patients metastatic non-small cell lung cancer. Patients received either EPC integrated oncology or alone....