A5059350220- Tracheal and airway disorders
- Vascular Malformations and Hemangiomas
- Health and Medical Research Impacts
- Tumors and Oncological Cases
- Airway Management and Intubation Techniques
- Teratomas and Epidermoid Cysts
- Head and Neck Anomalies
- Esophageal and GI Pathology
- Innovations in Medical Education
- Congenital Diaphragmatic Hernia Studies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Interpreting and Communication in Healthcare
- Patient-Provider Communication in Healthcare
- Health and Medical Education
- Emergency and Acute Care Studies
- Perfectionism, Procrastination, Anxiety Studies
- Hearing Loss and Rehabilitation
- Thyroid Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Health Sciences Research and Education
- Head and Neck Cancer Studies
- COVID-19 and healthcare impacts
- Voice and Speech Disorders
- Thyroid and Parathyroid Surgery
Seattle Children's Hospital
2019-2025
University of Washington
2019-2025
Seattle Institute for Biomedical and Clinical Research
2025
Massachusetts Eye and Ear Infirmary
2012-2023
Seattle University
2022
Massachusetts General Hospital
2022
Arkansas Children's Hospital
2017-2020
University of Arkansas for Medical Sciences
2013-2020
American College of Physicians
2019
Virginia Mason Medical Center
2019
Abstract Analysis of premalignant tissue has identified the typical order somatic events leading to invasive tumors in several cancer types. For other cancers, is unobtainable, leaving genetic progression unknown. Here, we demonstrate how infer from exome sequencing primary tumors. Our computational method, PhylogicNDT, recapitulated previous experimentally determined human papillomavirus-negative (HPV – ) head and neck squamous cell carcinoma (HNSCC). We then evaluated HPV + HNSCC, which...
OBJECTIVE Universal hearing screening is essential for early identification of infants with loss, yet there a lack low-cost, scalable equipment suitable resource-constrained settings. Here we test low-cost smartphone device infant screening. METHODS Infants aged 0 to 6 months were recruited from 3 ambulatory clinics at Seattle Children’s Hospital high prevalence loss. We compared results open-source distortion product otoacoustic emission (OAE) probe and app commercially available OAE...
Disparities have been described across racial and socioeconomic groups in adenotonsillectomy access surgical outcomes, but little is known about the impact of language. We studied effect race, ethnicity, language on frequency postoperative rates visits to emergency department, hospital admissions, return operating room. hypothesized that non-white, Hispanic, patients speaking a non-English would higher department visits, readmissions, Retrospective cohort analysis. Tertiary care academic...
Importance Head and neck lymphatic malformations (HNLMs) demonstrate considerable variability in their natural history. While some cause chronic severe functional impairment, others are asymptomatic spontaneously regress. Understanding the frequency features associated with regression will aid clinicians families making informed treatment choices avoid unnecessary risks of intervention for a subset patients. Objective To assess incidence, timing, factors spontaneous HNLMs. Design, Setting,...
Gaps between evidence-based research and clinical-public health practice have been evident for decades. One of the aims medical student is to close this gap. Accordingly, evaluating individual environmental factors that influence participation students in are needed understand identify potential targets action. This study characteristics researchers Colombia associated with scientific publications. A cross-sectional Colombian involved using a validated, self-administered, online survey. The...
Oropharyngeal squamous carcinoma (OPSC) continues to increase in incidence secondary human papillomavirus (HPV) infection. Despite the good overall prognosis for these patients, treatment with chemoradiation is associated morbidity and failure. Better predictors disease outcome are needed guide de-intensification regimens. We hypothesized that estrogen receptor α (ERα), a prognostic biomarker oncology therapeutic implications, might have similar utility OPSC.
Kruppel-like factor (KLF) proteins are emerging as key regulators of lipid metabolism, diabetes, and the biosynthesis immunological cytokines. However, their role in synthesis prostaglandins, widely known biochemical mediators that act a myriad cell biological processes remain poorly understood. Consequently, this study comprehensive investigation at cellular, biochemical, molecular levels reveal KLF11 inhibits prostaglandin E(2) via transcriptional silencing promoter its biosynthetic...
Coronavirus disease 2019 (COVID‐19) is a novel coronavirus resulting in high mortality the adult population but low pediatric population. The role children and adolescents play COVID‐19 transmission unclear, it possible that healthy patients serve as reservoir for virus. This article serves summary of single institution’s response to with goal protecting both health care providers while providing ongoing critically ill who require urgent interventions. A significant limitation this...
Objectives An increasing number of treatment modalities for lymphatic malformations are being described, complicating therapeutic decisions. Understanding malformation natural history is essential. We describe management head and neck where decisions primarily addressed lesion‐induced functional compromise (ie, breathing, swallowing) to identify factors associated with invasive active observation. hypothesize that non‐function threatening can be observed. Study Design Retrospective case...
Objectives/Hypothesis To delineate clinical characteristics and treatment outcomes of eosinophilic esophagitis (EoE) in the youngest children. Study Design Retrospective chart review. Methods A 7‐year retrospective review children with clinicopathologic diagnosis EoE was performed specific analysis patients under 5 years old. defined as presence symptoms esophageal dysfunction pathologically proven inflammation (≥15 eosinophils per high‐power field [EOS/HPF]) unresponsive to reflux therapy....
Abstract Background Assess the impact of a clinical pathway and progressive care unit (CPW/PCU) for patients undergoing head neck free flap reconstruction with regard to patient outcomes resource utilization. Methods Retrospective chart review 270 at an academic tertiary‐care center (2009‐2014). Outcomes were compared among control, CPW/PCU transition, groups. Results Compared group had significantly reduced medical complications (21.1%‐4.1%), intensive length stay (LOS, 5.02‐0.2 days),...
Evidence-based medicine (EBM) relies on scientific data to guide diagnosis and treatment is recognized as the current paradigm in medicine. Accordingly, every future physician should be knowledgeable about its principles methodologies. Embracing research EBM essential modern clinical practice; however, trainees physicians still struggle with value of research-related courses knowledge epidemiology methodology often poor. In this article we provide a cogent discussion importance an...
Objectives/Hypothesis The Seattle Children's Hospital implemented the Trach Safe Initiative to improve airway safety in tracheostomy‐dependent children (TDC). A key tenet of this initiative is surveillance endoscopy. objectives study were describe prevalence abnormal changes TDC, identify risk factors for these changes, and frequency interventions. Study Design Retrospective case series. Methods This a review 0 21 years old who underwent tracheostomy endoscopy from February 1, 2014 January...
Introduction Management of tracheostomy and laryngectomy is an important skill for physicians who often care patients with multiple, comorbid, chronic medical conditions. There little published literature on training during nonsurgical specialty residencies. This project was designed to assess improve comfort with, knowledge of, proficiency in care. Methods prospective observational study comprised 122 physician trainees from internal medicine, emergency anesthesia programs at the University...
Objective The objective of this study was to develop and assess multidisciplinary advanced surgical planning (ASP) sessions using three dimensional (3D) printed models for cervicothoracic slide tracheoplasty (CST). We hypothesized that these would improve surgeon confidence, streamline intraoperative planning, highlight the utility 3D modeling. Methods 3D‐printed patient‐specific trachea were used in pre‐operative ASP consisting a case discussion hands‐on simulation. Participants completed...