A5091603108- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Obstructive Sleep Apnea Research
- Airway Management and Intubation Techniques
- Tumors and Oncological Cases
- Anesthesia and Pain Management
- Head and Neck Anomalies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Vascular Malformations and Hemangiomas
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Neurotransmitter Receptor Influence on Behavior
- Congenital Diaphragmatic Hernia Studies
- Teratomas and Epidermoid Cysts
- Ear and Head Tumors
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Pediatric Pain Management Techniques
- Reconstructive Surgery and Microvascular Techniques
- Cannabis and Cannabinoid Research
- Thyroid and Parathyroid Surgery
Seattle Children's Hospital
2016-2025
University of Missouri–Kansas City
2025
University of Kansas
2025
University of Washington
2015-2024
Temple University
2023-2024
Harvard University
2023-2024
American Academy of Otolaryngology — Head and Neck Surgery
2023-2024
Florida State University
2024
AID Atlanta
2023
Indiana University – Purdue University Indianapolis
2016-2020
Abstract Recent studies have indicated that the brain‐derived neurotrophic factor ( BDNF ) gene is involved in etiology of bipolar disorder (BPD). Two family‐based association showed Val allele functional polymorphism Val66Met associated with BPD; however, others could not confirm results. Here we performed a replication study an independent sample and tested hypothesis Val66 confers susceptibility to I (BPI). Six hundred twenty‐one patients BPI 998 control subjects were genotyped for...
Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well national meetings, interest groups early research activity, is, yet, no consensus definition an aerodigestive patient, standardized structure, functions program blueprint for prioritization. The Delphi method was used by multidisciplinary...
To evaluate outcomes of the endoscopic posterior cricoid split with rib graft (EPCS/RG) procedure in treatment subglottic stenosis (SGS), glottic (PGS), and bilateral vocal fold immobility (BVFI).Retrospective chart review.Chart review all patients who underwent EPCS/RG at a single tertiary-care facility between 1999 2014. Patients were grouped based on primary indication for procedure. Decannulation was endpoint. Secondary endpoints number subsequent airway procedures length...
Abstract Pain management following pediatric tonsillectomy and adenotonsillectomy surgery is challenging traditionally involves perioperative opioids. However, the recent national opioid shortage compelled anesthesiologists at Bellevue Surgery Center to identify an alternative analgesic regimen that minimizes opioids yet provides effective pain relief. We assembled interdisciplinary quality improvement team trial a series of protocols using Plan‐Do‐Study‐Act cycle. Initially, we replaced...
Developing neurons must respond to a wide range of extracellular signals during the process brain morphogenesis. One mechanism through which immature such is by altering cellular actin dynamics. A recently discovered link between signaling events and cytoskeleton WASP/WAVE (Wiscott-Aldrich Syndrome protein/WASP-family verprolin-homologous protein) family proteins. Through direct interaction with Arp2/3 (actin-related complex, this functions regulate mediating from cdc42 as well other small...
Background: The incidence of pediatric thyroid cancer has been increasing, and care varies due to socioeconomic disparities or differing practice patterns. Clinical guidelines call for in multidisciplinary teams minimize variance provide protocols. Based on expert opinion, we hope describe the form function such programs. Methods: A modified Delphi method reach consensus statements over two rounds. Twenty-one experts with varying backgrounds responded each statement a 9-point Likert scale....
Disparities have been described across racial and socioeconomic groups in adenotonsillectomy access surgical outcomes, but little is known about the impact of language. We studied effect race, ethnicity, language on frequency postoperative rates visits to emergency department, hospital admissions, return operating room. hypothesized that non-white, Hispanic, patients speaking a non-English would higher department visits, readmissions, Retrospective cohort analysis. Tertiary care academic...
Abstract Objective Endoscopy is the gold‐standard diagnostic modality for many pediatric airway disorders but does not enable quantitative assessment of morphology. In a series patients, we aim to demonstrate that structure from motion (SfM) photogrammetry, computer‐vision algorithm, can accurately reconstruct three‐dimensional (3D) models laryngeal anatomy directly bronchoscopy videos. Study Design Prospective case series. Setting Tertiary academic hospital. Methods Pediatric patients...
Objective To determine whether the degree of lateral pharyngeal wall (LPW) obstruction on pediatric drug‐induced sleep endoscopy (DISE) correlates with preprocedure tonsillar hypertrophy score physical examination, and to if clinically small tonsils are obstructive. Methods Retrospective review 154 patients who underwent DISE at a single tertiary care center over 4‐year period. Inclusion criteria were documentation Brodsky tonsil preoperative examination. Exclusion previous tonsillectomy,...
Objective To describe the Trach Safe Initiative and assess its impact on unanticipated tracheostomy‐related mortality in outpatient tracheostomy‐dependent children (TDC). Methods An interdisciplinary team including parents providers designed initiative with quality improvement methods. Three practice changes were prioritized: (1) surveillance airway endoscopy prior to hospital discharge from tracheostomy placement, (2) education for community‐based nurses TDC‐focused emergency management,...
Objective Nanofiber‐supported, in vitro–generated cartilage may represent an optimal starting material for the development of a implant use microtia reconstruction. To do so, authors aim to first characterize molecular composition endogenous auricular and determine if human umbilical cord mesenchymal stem cells (hUCMSCs) can be differentiated into vitro. Study Design Prospective, controlled. Setting Academic research laboratory. Subjects Methods Human ear from normal adults, pediatric...
More than 50 individuals with activating variants in the receptor tyrosine kinase PDGFRB have been reported, separated based on clinical features into solitary myofibromas, infantile myofibromatosis, Penttinen syndrome premature aging and osteopenia, Kosaki overgrowth syndrome, fusiform aneurysms. Despite their descriptions as distinct entities, review of previous reports demonstrates substantial phenotypic overlap. We present a case series 12 patients literature. describe five whose overlap...
Coronavirus disease 2019 (COVID‐19) is a novel coronavirus resulting in high mortality the adult population but low pediatric population. The role children and adolescents play COVID‐19 transmission unclear, it possible that healthy patients serve as reservoir for virus. This article serves summary of single institution’s response to with goal protecting both health care providers while providing ongoing critically ill who require urgent interventions. A significant limitation this...
We have examined the relationship between Na,K-ATPase and FGF-2 secretion in transfected primate cells. lacks a classic hydrophobic export signal, mechanisms mediating its are unknown. To monitor secretion, FLAG epitope tag was inserted into carboxyl terminus of 18 kDa form human FGF-2, construct either HEK 293 or monkey CV-1 Exported detected culture medium using FLAG-specific monoclonal antibody M2. from cells linear over time sensitive to inhibition by cardiac glycoside ouabain, specific...
Abstract The endogenous opioid system has been shown to have a role in the biological processes involved addiction numerous drugs of abuse including cocaine. It recently reported that variable nucleotide tandem repeat (VNTR) polymorphism 5′ promoter region prodynorphin gene, which encodes precursor for three peptides, is associated with cocaine dependent phenotype. In order confirm this finding, we genotyped (n = 167) and control 88) individuals African descent. results from experiment...