A5075185179- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- Child Nutrition and Feeding Issues
- Respiratory and Cough-Related Research
- Gastrointestinal motility and disorders
- Eosinophilic Disorders and Syndromes
- Education Systems and Policy
- Diverse Educational Innovations Studies
- Infant Health and Development
- Childhood Cancer Survivors' Quality of Life
- Clinical Nutrition and Gastroenterology
- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Pain Management Techniques
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Photoacoustic and Ultrasonic Imaging
- Infant Development and Preterm Care
- Transplantation: Methods and Outcomes
- Esophageal Cancer Research and Treatment
- Privacy-Preserving Technologies in Data
Harvard University
2012-2025
Boston Children's Hospital
2016-2025
NHS England
2021-2025
Harvard University Press
2011-2024
Massachusetts General Hospital
2024
Boston Children's Museum
2005-2022
Bridge University
2022
Google (United States)
2022
S.P.E.C.I.E.S.
2021
Fundación Juan March
2011-2020
ABSTRACT This document serves as an update of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) European (ESPGHAN) 2009 clinical guidelines diagnosis management gastroesophageal reflux disease (GERD) in infants children is intended to be applied daily practice a basis trials. Eight questions addressing diagnostic, therapeutic prognostic topics were formulated. A systematic literature search was performed from October 1, 2008 (if question...
Esophageal atresia (EA) is one of the most common congenital digestive anomalies. With improvements in surgical techniques and intensive care treatments, focus these patients has shifted from mortality to morbidity quality-of-life issues. These children face gastrointestinal (GI) problems not only early childhood but also through adolescence adulthood. There is, however, currently a lack systematic approach patients. The GI working group International Network on Atresia comprises members...
Machine learning models are commonly used to detect toxicity in online conversations. These trained on datasets annotated by human raters. We explore how raters' self-described identities impact they annotate comments. first define the concept of Specialized Rater Pools: rater pools formed based identities, rather than at random. three such for this study - specialized raters from U.S. who identify as African American, LGBTQ, and those neither. Each these same set comments, which contains...
Human annotated data plays a crucial role in machine learning (ML) research and development. However, the ethical considerations around processes decisions that go into dataset annotation have not received nearly enough attention. In this paper, we survey an array of literature provides insights crowdsourced annotation. We synthesize these insights, lay out challenges space along two layers: (1) who annotator is, how annotators' lived experiences can impact their annotations, (2)...
Previous evidence suggests an association between gastroesophageal reflux disease and chronic respiratory in children. Despite antisecretory antacid therapy, symptoms often persist supporting a role for nonacid reflux. The aim of this study was to determine whether occurs children with disease.Twenty-eight (mean age: 6.5 +/- 5.6 yr) persistent on medications underwent 24 h pH/multichannel intraluminal impedance (pH/MII) recording. symptom index (SI) the sensitivity (SSI) were calculated each...
The pathophysiology of dysphagia in patients with eosinophilic esophagitis (EoE) is unknown but may be related to abnormal esophageal motor function. Symptoms rarely occur during stationary manometry, so it has been difficult establish an association between symptoms and events. Our aim was evaluate function children EoE the use manometry ambulatory prolonged pH-metry (PEMP).PEMP performed compared controls gastroesophageal reflux disease (GERD). Peristalsis considered effective when...
To evaluate the clinical features of children with type I and II laryngeal cleft role conservative monitoring versus endoscopic repair in their management.Clinical presentation evaluation; findings at time laryngoscopy, bronchoscopy, esophagoscopy; efficacy outcome CO(2) laser repair.Eighty-one patients were evaluated for aspiration. Seventy-four diagnosed as having a clinically significant cleft. Thirty-two (14 males, 18 females) monitored conservatively. Forty-nine (26 23 required surgical...
The use of acid suppression has been associated with an increased risk upper and lower respiratory tract infections in the outpatient setting but mechanism behind this is unknown. We hypothesize that infection results from gastric bacterial overgrowth subsequent seeding lungs.To determine if acid-suppression overgrowth, there are changes lung microflora suppression, related to full-column nonacid gastroesophageal reflux.A 5-year prospective cohort study at a tertiary care center where...
Aerodigestive programs provide coordinated interdisciplinary care to pediatric patients with complex congenital or acquired conditions affecting breathing, swallowing, and growth. Although there has been a proliferation of programs, as well national meetings, interest groups early research activity, is, yet, no consensus definition an aerodigestive patient, standardized structure, functions program blueprint for prioritization. The Delphi method was used by multidisciplinary...
Discussing things you care about can be difficult, especially via online platforms, where sharing your opinion leaves open to the real and immediate threats of abuse harassment. Due these threats, people stop expressing themselves give up on seeking different opinions. Recent research efforts focus examining strengths weaknesses (e.g. potential unintended biases) using machine learning as a support tool facilitate safe space for discussions; example, through detecting various types negative...
Abstract Background Pepsin has been proposed as a biomarker of reflux‐related lung disease. The goal this study was to determine (i) if there is higher reflux burden measured by pH‐MII in patients that are pepsin positive the lung, and (ii) sensitivity predicting pathologic pH, MII, EGD. Methods We recruited children between ages 1–21 with chronic cough or asthma undergoing bronchoscopy, esophagogastroduodenoscopy (EGD), multichannel intraluminal impedance (pH‐MII) probe placement. profiles...
Abstract Objectives Nonacid gastroesophageal reflux (GER), particularly in patients taking acid suppression, has been implicated as a cause of respiratory infections. We hypothesize that children with cystic fibrosis (CF) and higher nonacid burden have greater rates Pseudomonas aeruginosa (Pa) infection than lower burden. Study Design reviewed the multichannel intraluminal impedance (pH‐MII) tracings 35 CF between 2003 2010. compared profiles those who were Pa positive negative. Results The...