John Leung
A5049289797- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Asthma and respiratory diseases
- Gastrointestinal disorders and treatments
- Food Allergy and Anaphylaxis Research
- Parasites and Host Interactions
- Liver Diseases and Immunity
- Esophageal and GI Pathology
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Digestive system and related health
- Gastroesophageal reflux and treatments
- Plant Surface Properties and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Celiac Disease Research and Management
- Glycosylation and Glycoproteins Research
- Gallbladder and Bile Duct Disorders
- Parasite Biology and Host Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Helminth infection and control
Dermatology Specialists
2024-2025
Boston University
2015-2024
Stanford University
2024
Carney Hospital
2024
Allakos (United States)
2016-2023
Tufts Medical Center
2012-2022
Tufts University
2009-2022
Food Allergy Research and Education
2022
University Medical Center
2019-2021
Tufts Children's Hospital
2014-2018
Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, a lack adequate treatments. Mast-cell activity may contribute to the pathogenesis conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils inhibits mast cells has shown potential in animal models as treatment for eosinophilic duodenitis.In this phase 2 trial, we randomly assigned adults who had symptomatic gastritis,...
Background & AimsPharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial assess the ability budesonide oral suspension (BOS), novel muco-adherent topical steroid formulation, reduce symptoms and eosinophilia in adolescents adults with EoE.MethodsIn this multicenter, double-blind, placebo-controlled, parallel-group trial, 93 EoE patients between ages 11 40...
The CC chemokine ligand 18 (CCL18) is one of the most highly expressed chemokines in human chronic inflammatory diseases. An appreciation role CCL18 these diseases has been hampered by lack an identified receptor. We report that receptor CCR8 a induced chemotaxis and calcium flux CCR8-transfected cells. bound with high affinity to its internalization. Human CCL1, known endogenous ligand, competed for binding Further, CCL1 heterologous cross-desensitization cells Th2 activated polarized...
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as driver of the hyperinflammatory response seen in COVID-19. However, our understanding specific immune responses to remains limited. Mast cells (MCs) and eosinophils are innate that play pathogenic roles many inflammatory responses. Here we report MC-derived proteases eosinophil-associated mediators elevated...
Aberrant accumulation and activation of eosinophils potentially mast cells (MCs) contribute to the pathogenesis eosinophilic gastrointestinal diseases (EGIDs), including esophagitis (EoE), gastritis (EG), gastroenteritis (EGE). Current treatment options, such as diet restriction corticosteroids, have limited efficacy are often inappropriate for chronic use. One promising new approach is deplete inhibit MCs with a monoclonal antibody (mAb) against sialic acid-binding immunoglobulin-like...
<b><i>Introduction:</i></b> Pathologic accumulation and activation of mast cells eosinophils are implicated in allergic inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on cells, and, at a lower extent, basophils. When engaged with antibody, Siglec-8 can induce apoptosis activated inhibit cell activation. AK002 humanized, non-fucosylated IgG1 anti-Siglec-8 antibody undergoing clinical...
End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. We sought develop a core outcome set (COS) controlled observational studies pharmacologic diet interventions adult pediatric patients with EoE. Candidate were generated from systematic literature reviews patient...
Abstract Helminth exposure appears to protect hosts from inappropriate inflammatory responses, such as those causing bowel disease. A recently identified, strongly proinflammatory limb of the immune response is characterized by T cell IL-17 production. Many autoimmune type diseases are associated with release. Because helminths these diseases, we examined production in helminth-colonized mice. We colonized mice Heligmosomoides polygyrus, an intestinal helminth, and analyzed lamina propria...
Background Knowledge about determinants of quality life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify at risk experiencing poor QoL and tailor therapeutic interventions accordingly. Aim To evaluate the impact symptom severity, endoscopic histological activity on EoE-specific adult EoE patients. Methods Ninety-eight were prospectively included (64% male, median age 39 years). Patients completed two validated instruments assess (EoO-QoL-A) severity (adult index...
Immunological diseases such as inflammatory bowel disease (IBD) are infrequent in less developed countries, possibly because helminths provide protection by modulating host immunity. In IBD murine models, the helminth Heligmosomoides polygyrus bakeri prevents colitis. It was determined whether H. mediated altering dendritic cell (DC) function. We used a Rag model where animals were reconstituted with IL10⁻/⁻ T cells, making them susceptible to and OVA Ag-responsive OT2 allowing study of gut...
In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory whereby likely triggered by non-IgE stimuli (e.g., IL-33). Siglec-8 an inhibitory receptor expressed on MCs eosinophils that has been shown inhibit IgE-mediated MC responses reduce inflammation upon ligation a monoclonal antibody (mAb). Herein, we evaluated the effects anti-Siglec-8 mAb (anti-S8)...
INTRODUCTION: Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim this study was to prospectively evaluate endoscopic features in large series children adults with EG better understand manifestations develop standardized instrument for investigations. METHODS: Data were collected as part Consortium Gastrointestinal Disease Researchers, national collaborative...
Abstract Regulation of N ‐methyl‐ d ‐aspartate (NMDA) receptors is critical for the normal functioning central nervous system. There must be precise mechanisms to allow changes in receptor function required learning and synaptic transmission, but within tight constraints prevent pathology. Tyrosine phosphorylation a major means by which NMDA are regulated through equilibrium between activity Src family kinases tyrosine phosphatases. Identification phosphatases has been difficult, best...