A5116130509- COVID-19 Clinical Research Studies
- Mast cells and histamine
- Long-Term Effects of COVID-19
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Food Allergy and Anaphylaxis Research
- Intensive Care Unit Cognitive Disorders
- Gastric Cancer Management and Outcomes
- T-cell and Retrovirus Studies
- Liver Disease Diagnosis and Treatment
- COVID-19 and Mental Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Public Health and Nutrition
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Endometriosis Research and Treatment
- Glycosylation and Glycoproteins Research
- Dermatology and Skin Diseases
- Mobile Health and mHealth Applications
- Allergic Rhinitis and Sensitization
- Ubiquitin and proteasome pathways
- Polyamine Metabolism and Applications
- Growth Hormone and Insulin-like Growth Factors
- Nerve injury and regeneration
Allakos (United States)
2020-2024
University of Nottingham
2022
National Health and Medical Research Council
2021
Public Health Scotland
2021
Intensive Care National Audit & Research Centre
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Public Health England
2021
Oxford University Clinical Research Unit
2021
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as driver of the hyperinflammatory response seen in COVID-19. However, our understanding specific immune responses to remains limited. Mast cells (MCs) and eosinophils are innate that play pathogenic roles many inflammatory responses. Here we report MC-derived proteases eosinophil-associated mediators elevated...
In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory whereby likely triggered by non-IgE stimuli (e.g., IL-33). Siglec-8 an inhibitory receptor expressed on MCs eosinophils that has been shown inhibit IgE-mediated MC responses reduce inflammation upon ligation a monoclonal antibody (mAb). Herein, we evaluated the effects anti-Siglec-8 mAb (anti-S8)...
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role pathogenesis. Targeting Siglec-8, an inhibitory receptor on eosinophils, has shown promising preclinical clinical studies. While the intracellular pathways that regulate Siglec-8 eosinophils been well studied, signaling mechanisms lead to MC inhibition not fully elucidated. Here, we evaluate Siglec-8-mediated primary using anti-Siglec-8 monoclonal antibody (mAb)....
Abstract Mast cells (MC) are key drivers of allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-6 is an immunoregulatory receptor found on MCs. While it recognized that engaging Siglecs with antibodies mediates inhibition across immune cells, the mechanisms govern this agonism not understood. Here we generated Siglec-6 mAb clones (AK01 to AK18) better understand Siglec-6-mediated agonism. mAbs displayed epitope-dependent internalization inhibitory...
Abstract Background Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐6 and Siglec‐8 are closely related mast cell (MC) receptors with broad inhibitory activity, but whose functional differences incompletely understood. Methods Proteomic profiling using quantitative mass spectrometry was performed on primary mouse MCs to identify proteins associated Siglec‐6 Siglec‐8. For characterization, each receptor evaluated biochemically in ex vivo inhibition models of IgE non‐IgE‐mediated MC...
Methods In the Northern California Childhood Leukaemia Study, a case–control study with incident cases and matched birth certificate controls, detailed written vaccination records were collected. A total of 323 aged 0–14 years at diagnosis 409 controls included in this analysis. All vaccinations censored on reference date (date for corresponding controls). Conditional logistic regression analysis was conducted, adjusting potential confounding factors. primary variable interest is number...
Abstract Atopic dermatitis (AD) is a debilitating type 2 inflammatory disease of the skin characterized by pruritus. Mast cells (MCs) and eosinophils (eos) are elevated in AD tissue. Siglecs inhibitory receptors found on immune cells, with Siglec-8 selectively expressed MCs eos. Engagement antibody results broad inhibition MC activation (IgE-dependent -independent pathways). eos key drivers itch. Crosstalk between sensory neurons contributes to non-histaminergic itch via Mas-related...
Abstract Background this study aimed to determine the level of digital literacy in adult Singaporeans community and its association with demographic characteristics, physical activity, self-rated health bodily pain, identify needs frequent internet users. Methods a cross-sectional survey was carried out among individuals living Punggol, Singapore on 2 June 2018. Survey data were using 20-minute self-completion questionnaire. The questionnaire included validated 8-item eHealth Literary Scale...
Cutaneous endometriosis (CEM) is a rare disease characterized by endometrial glands and/or stroma in the skin. Lesions present as firm papule or nodule and can be blue, violaceous, red, brown skin-colored. Patients frequently report cyclical tenderness, swelling bleeding at site of lesion related to their menstrual cycle. CEM presents diagnostic challenge lesions are commonly mistaken for keloid, dermatofibroma, dermatofibrosarcoma protuberans, melanoma cutaneous metastasis cancer (e.g.,...
Rationale: Clinical outcomes after coronavirus-2019 disease (COVID-19) have been well described, including persistent symptoms and abnormalities on pulmonary function tests imaging. However, the presence underlying mechanism of functional impairments COVID-19 remain unclear. Methods: Patients with SARS-CoV-2 confirmed by real-time polymerase chain reaction were recruited from a hospital in Yucatan, Mexico. who able to complete surveys, tests, 6-minute walk within 30-90 days symptom onset...