Calies Menard‐Katcher
A5008257308- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Pediatric health and respiratory diseases
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Feeding Issues
- Gastrointestinal motility and disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Refrigeration and Air Conditioning Technologies
- Neonatal Health and Biochemistry
- Delphi Technique in Research
- Tracheal and airway disorders
- Poisoning and overdose treatments
- Esophageal Cancer Research and Treatment
University of Colorado Denver
2016-2025
Children's Hospital Colorado
2016-2025
University of Colorado Anschutz Medical Campus
2016-2021
American Society for Gastrointestinal Endoscopy
2016-2017
Research Network (United States)
2016
American Partnership for Eosinophilic Disorders
2015
University of Pennsylvania
2009-2014
Children's Hospital of Philadelphia
2009
Philadelphia University
2009
Introduction Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis ( non‐EoE EGIDs ) are rare chronic inflammatory of the (GI) tract. Diagnosis is based on clinical symptoms and histologic findings inflammation after exclusion a secondary cause or systemic disease. Currently, no guidelines exist for evaluation . Therefore, European Society Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) North American Pediatric (NASPGHAN) formed task force group to provide...
The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and colitis (EC) is limited. We aimed characterize rates of diagnosis, clinical features, initial treatments for patients with EG, EGE, EC. In this retrospective study, data were collected from 6 centers in the Consortium Eosinophilic Gastrointestinal Researchers 2005 2016. analyzed demographics, time trends medical history, presenting symptoms, disease overlap, treatment patterns/responses. Of 373 subjects (317...
Objectives: Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration inflammation is a predicted risk factor; however, complications remain unpredictable. Studies using the functional lumen imaging probe (FLIP) have demonstrated decreased distensibility esophagus in adult patients with EoE. As impact on developing unknown, we investigated pediatric cohort to determine effect age, ongoing inflammation, fibrotic features distensibility. Methods: We...
End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. We sought develop a core outcome set (COS) controlled observational studies pharmacologic diet interventions adult pediatric patients with EoE. Candidate were generated from systematic literature reviews patient...
Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options management, but the decision-making process for determining varies among practitioners. To reduce variability in practice patterns help clinicians monitor clinical course disease an office setting, we aimed to create international consensus scoring index EoE.
In contrast to peptic strictures, clinically significant strictures in patients with eosinophilic esophagitis (EoE) may be subtle and go unrecognized at the time of endoscopy. We aimed identify how often stricture was identified by endoscopy as compared esophagram.We retrospectively reviewed esophagram examinations all EoE esophageal seen a tertiary care pediatric hospital over 6-year period who had both procedures completed within 3-month frame. Medical charts were for clinicopathologic...
ABSTRACT Objectives: Existing treatments for pediatric eosinophilic esophagitis (EoE) effectively reduce inflammation. The impact of treatment on health‐related quality life (HRQoL) over time patients with EoE and their families, however, has not been systematically assessed. We hypothesized that individualized multidisciplinary would improve both child family HRQoL time, improvements associated decreased symptom severity. Methods: Children treated in 4 tertiary care centers were enrolled....
As both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with malnutrition feeding dysfunction, this study compares growth, nutrition, behaviors in children GERD EoE.Subjects ages 1 to 7 years or EoE were enrolled a prospective study. Assessments included length/height, weight, 3-day food diary, serum biomarkers of the Behavioral Pediatric Feeding Assessment Scale.Mean weight-for-length z scores -0.93 -1.14 (p = NS) mean body mass index 0.29 -0.13 (P...
Children with eosinophilic esophagitis (EoE) experience daily challenges related to coping symptoms and the psychosocial effect of this chronic disease. The aim study was identify features dysfunction experienced by children EoE who were evaluated in a tertiary care program.We performed retrospective review patients their families' evaluations program. Consecutive analyzed document reports patients' disease-related pain/discomfort; feeding/appetite symptoms; sleep, social, school problems;...
ABSTRACT Objectives: Although several studies report on the experience with adult eosinophilic esophagitis (EoE)–related stricture, outcomes for pediatric patients EoE–associated fibrostenosis and stricture is more limited. To address this, we aim to identify adverse event (AE) rate short‐term of largest reported cohort children EoE undergo esophageal dilation management symptomatic narrowing. Methods: A retrospective assessment all children, 18 years younger, who underwent at an academic...
Swallowed topical steroids (STS) are the only effective pharmacological therapy for eosinophilic esophagitis (EoE). Thus far, studies of small populations EoE patients have reported conflicting results in relation to adrenal insufficiency (AI). We sought measure AI a clinical setting children taking STS EoE. performed quality improvement study pediatric seen multidisciplinary clinic, who were treated with at least 3 months. Two hundred twenty-five completed questionnaires assess signs AI....
Background & AimsWe evaluated treatment withdrawal, long-term outcomes, and safety of budesonide oral suspension (BOS) 2.0 mg twice daily in patients with eosinophilic esophagitis who completed a 12-week induction study.MethodsInduction full responders (≤6 eosinophils per high-power field [eos/hpf] ≥30% reduction the Dysphagia Symptom Questionnaire score) to BOS (ORBIT1/SHP621-301/NCT02605837) were randomized continue (BOS–BOS) or withdraw placebo (BOS–PBO) for 36 weeks...
Aims A growing body of evidence suggests a role for altered epithelial barrier function in the pathophysiology eosinophilic oesophagitis (EoE), but few have described structure during inflammation. The purpose this study was to define ultrastructural features active, inactive EoE and control subject's oesophageal epithelia. Methods We prospectively enrolled patients undergoing diagnostic upper endoscopy evaluation EoE. Mucosal pinch biopsies were obtained from distal oesophagus processed...