A5089407589- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Teratomas and Epidermoid Cysts
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Thyroid Disorders and Treatments
- Oral and Maxillofacial Pathology
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Hearing, Cochlea, Tinnitus, Genetics
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Congenital Ear and Nasal Anomalies
- Nasal Surgery and Airway Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Craniofacial Disorders and Treatments
- Marine animal studies overview
- Immunotherapy and Immune Responses
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Temple University
2024
Harvard University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Philadelphia University
2003-2022
Cochlear (United States)
2007
North American Skull Base Society
2007
Hospital of the University of Pennsylvania
2001
Penn Presbyterian Medical Center
1992-1994
The potential roles of CD8(+) T-cell-induced chemokines in the expansion immune responses were examined using DNA immunogen constructs as model antigens. We coimmunized cDNA expression cassettes encoding alpha-chemokines IL-8 and SDF-1alpha beta-chemokines MIP-1alpha, RANTES, MCP-1 along with immunogens analyzed resulting antigen-specific responses. In a manner more similar to traditional modulatory role CD4(+) T cells via Th1 or Th2 cytokines, appeared play an important effector function by...
In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary thyroid cancer samples reported by The Cancer Genome Atlas project suggested that reclassification into molecular subtypes,
Background: Thyroid nodules are less common in pediatric patients (i.e., those ≤18 years) than they adults. The Bethesda System for Reporting Cytopathology allows individual risk stratification, but a significant number of indeterminate. Incorporating gene mutation panels and expression classifiers may aid preoperative diagnosis. overall aim this study was to assess the prevalence oncogene alterations representative population across broad-spectrum thyroid tumor diagnoses. Methods: This...
The incidence and spectrum of tongue lesions in children, particular hamartomas, is relatively unknown. We report a retrospective review all seen at major tertiary care children's hospital over an 18-year period with emphasis on describing hamartomas. A total 135 were identified. Vascular/lymphatic (36/135) the most common followed by mucus extravasation phenomenon (22/135). Interestingly, hamartomatous (18/135) third lesion category Lingual hamartomas predominantly submucosal location...
Current guidelines recommend total thyroidectomy for the majority of pediatric thyroid cancer owing to an increased prevalence multifocality. However, there is a paucity information on exact and risk factors multifocal disease-knowledge that critical improving management outcomes.To determine disease in patients with papillary carcinoma (PTC).This multicenter retrospective cohort study included 18 years or younger who underwent PTC from 2010 2020 at 3 tertiary hospitals 2 adult...
There has been significant progress in understanding the molecular landscape of pediatric differentiated thyroid carcinoma over past two decades. Classification into three-tiers, RAS-like mutant, BRAF-mutant, and kinase-fusions, accurately reflects an increasing risk for invasive behavior, including regional distant metastasis. In clinical practice, somatic oncogene testing nodules with indeterminate cytology per Bethesda System Reporting Thyroid Cytopathology provides objective data to...
Introduction: The American Joint Committee Cancer (AJCC) TNM system predicts survival in patients with differentiated thyroid cancer (DTC). In the eighth edition of AJCC TNM, microscopic extrathyroidal extension (microETE) was removed and tumor size >4 cm maintained definition T3 disease to reduce unnecessarily aggressive therapy for adults at low risk death from DTC. pediatric where DTC rates are high, is used identify increased persistent, postsurgical disease, who benefit radioactive...
Abstract Context The American Thyroid Association (ATA) Pediatric Guidelines recommend patients not receive radioactive iodine therapy (RAIT) for differentiated thyroid cancer (DTC) confined to the thyroid. Since publication, there is ongoing concern whether withholding RAIT will result in a lower rate of remission. Objective This study explores ATA low-risk treated with and without achieved similar remission rates. Methods Medical records <19 years old diagnosed DTC total...
The current recommendation for pediatric patients with papillary thyroid cancer (PTC) is a total thyroidectomy. This applies to all stages of PTC, including microcarcinoma (≤1 cm, T1a) tumors.To evaluate the characteristics American Joint Committee on Cancer T1 PTC tumors in large population and identify subgroup who may benefit from lobectomy instead thyroidectomy.This retrospective cohort study was conducted January 1, 2009, May 31, 2020. took place at tertiary care medical center included...
Traditionally, data regarding thyroidectomy were extracted from billing databases, but information may be missed. In this study, a multi-institutional pediatric database was used to evaluate recurrent laryngeal nerve (RLN) injury and hypoparathyroidism. Retrospective cohort study. Tertiary care hospital systems throughout North America. Data individually collected for thyroidectomies, then entered into centralized analyzed using univariate multivariable regression models. total, 1025...
The management of chronic sinusitis (CS) in children has yet to be fully elucidated. objective this study is assess practice trends within the pediatric otolaryngology community for with CS.A multiple choice survey members American Society Pediatric Otolaryngology (ASPO) was performed various factors related CS children.A total 175 ASPO responded survey. majority respondents initially treat patients medically oral antibiotics (95%), topical steroids (90%), and nasal saline sprays (68%)....
Background: Hypoparathyroidism is one of the most common complications for patients undergoing total thyroidectomy. Our study's primary objective was to assess if intraoperative PTH levels correlate with parathyroid gland function recovery time in pediatric following Methods: Retrospective review who underwent thyroid surgery at CHOP demographics and laboratory test values (calcium, phosphorus, hormone). We defined Time Recovery (TOR) as difference from first intra-operative hormone level...
Malignant melanoma of the ear canal is an exceedingly rare disease process, especially in children under 15 with only one case previously described literature. This report describes clinical course a young man initially diagnosed malignant at age 10 and subsequently underwent surgical intervention, chemotherapy, immunotherapy as well radiation therapy. Despite extensive treatment patient unfortunately succumbed to metastatic 17 months after his initial diagnosis. The goal this manuscript...