A5017202683- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Cancer therapeutics and mechanisms
- Acute Myeloid Leukemia Research
- Statistical Methods in Clinical Trials
- Neuroendocrine Tumor Research Advances
- Adolescent and Pediatric Healthcare
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Family Support in Illness
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Pharmaceutical studies and practices
- Sepsis Diagnosis and Treatment
- Ethics in Clinical Research
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Advanced Neuroimaging Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Virus-based gene therapy research
- Energy Efficient Wireless Sensor Networks
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2014-2025
Indiana University – Purdue University Indianapolis
2014-2025
St. Jude Children's Research Hospital
2013-2025
Zhejiang University
2022-2024
Nanjing University of Chinese Medicine
2024
Xizang Minzu University
2021-2024
University of Virginia Children's Hospital
2024
Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, number of cell-cycle proteins, particularly those within the Cyclin D/CDK4/CDK6/RB network, have been shown exert oncogenic roles in neuroblastoma, suggesting their therapeutic exploitation might improve patient outcomes.We evaluated effect dual CDK4/CDK6 inhibition on neuroblastoma viability using LEE011 (Novartis Oncology), highly specific CDK4/6 inhibitor.Treatment with significantly...
PURPOSE To prospectively evaluate the effectiveness of risk-adapted preemptive tocilizumab (PT) administration in preventing severe cytokine release syndrome (CRS) after CTL019, a CD19 chimeric antigen receptor T-cell therapy. METHODS Children and young adults with CD19-positive relapsed or refractory B-cell acute lymphoblastic leukemia were assigned to high- (≥ 40%) low- (< tumor burden cohorts (HTBC LTBC) based on bone marrow aspirate biopsy before infusion. HTBC patients received single...
Tisagenlecleucel is a CD19-specific chimeric antigen receptor T-cell therapy, US Food and Drug Administration-approved for children, adolescents, young adults (CAYA) with relapsed and/or refractory (RR) B-cell acute lymphoblastic leukemia (B-ALL). The Administration registration tisagenlecleucel was based on complete response (CR) rate of 81%, 12-month overall survival (OS) 76%, event-free (EFS) 50%. We report clinical outcomes analyze covariates after commercial tisagenlecleucel.We...
PURPOSE CD19-targeted chimeric antigen receptor (CAR)–modified T cells demonstrate unprecedented responses in B-cell acute lymphoblastic leukemia (B-ALL); however, relapse remains a substantial challenge. Short CAR T-cell persistence contributes to this risk; therefore, strategies improve are needed. METHODS We conducted pilot clinical trial of humanized CD19 product (huCART19) children and young adults with relapsed or refractory B-ALL (n = 72) B-lymphoblastic lymphoma 2), treated two...
We conducted a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract therapy in patients with mild to moderate generalized anxiety disorder (GAD). hypothesized that chamomile would be superior placebo reducing GAD symptoms comparable profile.Sixty-one outpatients were enrolled, 57 randomized either double-blind (n = 28) or 29) for 8 weeks. The study was powered detect statistically significant clinically meaningful group...
Neuroblastomas harboring activating point mutations in anaplastic lymphoma kinase (ALK) are differentially sensitive to the ALK inhibitor crizotinib, with certain conferring intrinsic crizotinib resistance. To overcome this clinical obstacle, our goal was identify inhibitors improved potency that can target intractable variants such as F1174L. We find PF-06463922 has high across and inhibits more effectively than vitro. Most importantly, induces complete tumor regression both...
Abstract Chromosome 6p22 was identified recently as a neuroblastoma susceptibility locus, but its mechanistic contributions to tumorigenesis are yet undefined. Here we report that the most highly significant single-nucleotide polymorphism (SNP) associations reside within CASC15, long noncoding RNA define tumor suppressor at 6p22. Low-level expression of short CASC15 isoform (CASC15-S) associated with advanced and poor patient survival. In human cells, attenuating CASC15-S increased cellular...
Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us examine downstream effectors this pathway and identify mitotic regulator Wee1 as an additional therapeutic target in disease. was overexpressed both neuroblastoma cell lines high-risk patient tumors. Genetic or pharmacologic abrogation signaling results marked cytotoxicity 10 11 with a median IC(50) 300 nmol/L for Wee1-selective small-molecule inhibitor MK-1775. Murine tumor...
Nonresponse and relapse after CD19-chimeric antigen receptor (CAR) T-cell therapy continue to challenge survival outcomes. Phase II landmark data from the ELIANA trial demonstrated nonresponse rates of 14.5% 28%, respectively, whereas use in real-world setting showed 15% 37%. Outcome analyses describing fate post-CAR remain limited. Here, we aim establish outcomes both CD19+ CD19- relapses explore treatment variables associated with inferior survival.
Abstract Phytosulfokine (PSK), a plant peptide hormone with wide range of biological functions, is recognized by its receptor PHYTOSULFOKINE RECEPTOR 1 (PSKR1). Previous studies have reported that PSK plays important roles in growth, development, and stress responses. However, the involvement fruit development quality formation remains largely unknown. Here, using tomato (Solanum lycopersicum) as research model, we show exogenous application promotes initiation ripening formation, while...
PAX5, a B cell-specific transcription factor, is overexpressed through chromosomal translocations in subset of cell lymphomas. Previously, we had shown that activation immunoreceptor tyrosine-based motif (ITAM) proteins and receptor (BCR) signaling by PAX5 contributes to B-lymphomagenesis. However, the effect on other oncogenic factor-controlled pathways unknown. Using MYC-induced murine lymphoma model as well MYC-transformed human lines, found controls c-MYC protein stability steady-state...
Background Infertility is an unfortunate treatment-related consequence for some pediatric malignancies as well non-malignant conditions treated with stem cell transplant. Unlike pubertal males, prepubertal males cannot produce semen cryopreservation. This manuscript reports on the acceptability and safety of a multi-institutional protocol offering testicular tissue cryopreservation to families male children at highest risk infertility. Data decision influences, decision-making control,...
Background: In the United States, cancer is common, with high morbidity and mortality; incidence varies between states. Online searches reflect public awareness, which could be driven by underlying regional epidemiology.
Acquired aplastic anemia (aAA) is an acquired deficiency of early hematopoietic cells, characterized by inadequate blood production, and a predisposition to myelodysplastic syndrome (MDS) leukemia. Although its exact pathogenesis unknown, aAA thought be driven Human Leukocyte Antigen (HLA)-restricted T cell immunity, with earlier studies favoring HLA class II-mediated pathways. Using whole exome sequencing (WES), we recently identified two patients somatic mutations in I genes. We...
Background Dexrazoxane may reduce anthracycline-associated cardiotoxicity in pediatric cancer patients. However, concerns of secondary acute myeloid leukemia (AML) have led to restrictions on dexrazoxane use Europe. Published data about dexrazoxane-associated AML are limited and conflicting. We sought estimate the risk children receiving after anthracycline exposure. Procedure A retrospective cohort with newly identified malignancies (excluding AML) anthracyclines between January 1, 1999...
Purpose: Neuroblastoma is treated with aggressive multimodal therapy, yet more than 50% of patients experience relapse. We recently showed that relapsed neuroblastomas frequently harbor mutations leading to hyperactivated ERK signaling and sensitivity MEK inhibition therapy. Here we sought define a synergistic therapeutic partner potentiate inhibition.Experimental Design: first surveyed 22 genetically annotated human neuroblastoma-derived cell lines (from 20 unique patients) for the...
Background: Thyroid nodules are less common in pediatric patients (i.e., those ≤18 years) than they adults. The Bethesda System for Reporting Cytopathology allows individual risk stratification, but a significant number of indeterminate. Incorporating gene mutation panels and expression classifiers may aid preoperative diagnosis. overall aim this study was to assess the prevalence oncogene alterations representative population across broad-spectrum thyroid tumor diagnoses. Methods: This...
Whether social determinants of health are associated with survival in the context pediatric oncology-targeted immunotherapy trials is not known. We examined association between poverty and event-free (EFS) overall (OS) for children high-risk neuroblastoma treated targeted trials.We conducted a retrospective cohort study 371 GD2-targeted Children's Oncology Group trial ANBL0032 or ANBL0931 at Pediatric Health Information System center from 2005 to 2014. Neighborhood exposure was characterized...
Acute lung injury is a fatal condition characterized by excessive inflammation responses. Salidroside, the active constituent of Rhodiola rosea, possesses properties including anti-oxidation, anti-aging, anti-inflammatory, anti-hypoxia, and anti-cancer activities. In present study, Salidroside attenuated acute via inhibition inflammatory cytokine production. Rats pre-treated with showed lipopolysaccharide (LPS)-induced pathological damage suppressed tumor necrosis factor-alpha (TNFα)...