A5016539282- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Advancements in Semiconductor Devices and Circuit Design
- Nanowire Synthesis and Applications
- Lung Cancer Treatments and Mutations
- Hospital Admissions and Outcomes
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- Iron Metabolism and Disorders
- Integrated Circuits and Semiconductor Failure Analysis
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Virus-based gene therapy research
- Eosinophilic Disorders and Syndromes
- Cytomegalovirus and herpesvirus research
- Blood Coagulation and Thrombosis Mechanisms
- Vascular anomalies and interventions
- CNS Lymphoma Diagnosis and Treatment
- Head and Neck Anomalies
- Nausea and vomiting management
Children's Hospital of Philadelphia
2020-2025
University of Pennsylvania
2021-2025
Pediatrics and Genetics
2022
Children's Hospital of Pittsburgh
2021
University of Pittsburgh Medical Center
2021
Treatment options for patients with relapsed or refractory (R/R) anaplastic large cell lymphoma (ALCL) have increased in the era of targeted therapies such as brentuximab vedotin (BV) and Anaplastic Lymphoma Kinase (ALK) inhibitors. However, there is no standard treatment limited published data evaluating their use. The goal this retrospective study to describe current real-world outcomes pediatric, adolescent, young adult R/R ALK-positive ALCL. We conducted a retrospective,...
ABSTRACT Background Management of neonatal portal vein thrombosis (PVT), a relatively common type pediatric deep thrombosis, is not completely standardized. Questions remain about the benefit anticoagulation (ATC) therapy and optimal frequency duration doppler ultrasound (US) surveillance for liver complications such as hypertension gastrointestinal bleeding. Current guidelines suggest reserving ATC only occlusive PVT, highlighting need explicit grading PVT in radiologic reports consensus...
ABSTRACT Epstein–Barr virus (EBV)‐positive smooth muscle tumors (SMTs) are rare seen in immunocompromised patients. There is no clear standard of care for the management and treatment EBV‐SMTs. Patients often treated with chemotherapy, surgery, and/or radiation. Additional options include antiretroviral treatment, reduction immunosuppression, EBV‐directed virus‐specific T cells (VSTs). This report describes regimens outcomes eight patients EBV‐associated SMTs. Although consensus EBV‐SMTs has...
Relapse after CD19-directed chimeric antigen receptor (CAR)-modified T cells remains a substantial challenge. Short CAR T-cell persistence contributes to relapse risk, necessitating novel approaches prolong durability. reinfusion (CARTr) represents potential strategy reduce the risk of or treat relapsed disease initial infusion (CARTi). We conducted retrospective review murine (CTL019) humanized (huCART19) anti-CD19/4-1BB across 3 clinical trials commercial tisagenlecleucel for prevention...
10511 Background: CNS relapse of B-ALL is difficult to treat after cranial radiation or multiple relapses. Durable remissions relapsed/refractory (r/r) have been seen with CD19 CAR T cells; however, most trials excluded patients active disease. As we observed trafficking into the CSF, hypothesized that cells could control B-ALL. Methods: We identified children and young adults r/r treated on 4 clinical cells, CTL019 CTL119. NCT01626495 NCT02435849 disease, while former in an amendment as...
There are limited data pertaining to the prognostic features and optimal therapeutic approach for 20%-25% of children with lymphoblastic lymphoma (LLy) who have B-lymphoblastic subtype. Outcomes favorable following treatment modeled after acute leukemia (ALL) regimens, but prognosis is dismal relapse, there no established predicting therapy response. Ongoing US international trials will include largest cohort uniformly treated patients B-LLy date, providing an opportunity define clinical...
Abstract Pediatric recipients of intestinal transplants have a high incidence PTLD, but the impact specific induction immunosuppression agents is unclear. In this single‐center retrospective review from 2000 to 2017, we describe incidence, characteristics, and outcomes PTLD after primary transplantation in 173 children with or without liver, rATG, alemtuzumab, anti‐IL‐2R agents. Thirty cases occurred among 28 children, EBV+ 2 EBV−. Although not statistically significant, was higher isolated...
Abstract Background After solid organ transplantation, children are at risk for Epstein–Barr virus‐associated post‐transplant lymphoproliferative disorder and smooth muscle tumors. Little is known about the clinical course, viral load variations, optimal treatment such patients. We set forth to understand course of repeated episodes Methods performed a retrospective chart review patients up 21 years old with transplantation Children's Hospital Philadelphia from January 2003 through June 30,...
Background: Pediatric B-lymphoblastic lymphoma is an uncommon subtype of non-Hodgkin lymphoma. Studies regarding the biology, clinical course, and approach to relapse are limited. Observations: We present a series children with describe course at diagnosis as well role tumor cytogenetics, immunotherapy, hematopoietic stem cell transplant. Conclusions: The prognostic significance cytogenetic changes in not described but may offer improved risk stratification. Immunotherapy salvage options for...
A previously healthy 30-month-old boy presents to the oncology clinic for evaluation of an abdominal mass discovered that day by ultrasonography. His parents first noticed distention around his birthday, and it seemed progressively grow over subsequent months. He remained well-appearing with normal growth along curves (approximately 35th percentile weight 30th height). raised their concerns pediatrician several months after birthday but were reassured because abdomen was soft palpation no...
A previously healthy 14-year-old girl is referred to the hematology clinic for evaluation of microcytic anemia. She has no significant medical or family history. On review systems she reports several weeks progressive fatigue, worsening headaches, and intermittent lightheadedness. denies any history bleeding, including blood in her stool urine. premenarchal. rashes, arthralgias, abdominal pain, bloating, nausea, vomiting, diarrhea, constipation, intolerance foods. There inflammatory bowel...
As hospitalized pediatric patients have grown in number and complexity, residency structural changes reduced resident coverage, inpatient care models changed to include additional providers at the “front line.” Hospitalists are increasingly employed general units, but specialized areas, hospitalist less common. Hospitalist programs oncology few unique, thus there limited data assessing this role. Here we describe oncology/stem cell transplant program Children’s Hospital of Philadelphia with...
Children with cancer and those undergoing hematopoietic stem cell transplantation frequently require anesthesia for imaging as well diagnostic therapeutic procedures from diagnosis through follow-up. Due to their underlying disease side effects of chemotherapy radiation, they are at risk complications during this time, yet no published guideline exists preanesthesia preparation. A comprehensive literature review served the basis discussions among our multidisciplinary panel oncologists,...