A5012796073- Hemoglobinopathies and Related Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Platelet Disorders and Treatments
- Advanced Glycation End Products research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Complement system in diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Hematopoietic Stem Cell Transplantation
- Vascular Malformations and Hemangiomas
- Vascular anomalies and interventions
- Erythrocyte Function and Pathophysiology
- Hemophilia Treatment and Research
- ATP Synthase and ATPases Research
- Erythropoietin and Anemia Treatment
- Chronic Myeloid Leukemia Treatments
- Prenatal Screening and Diagnostics
- Acute Myeloid Leukemia Research
- Lipid metabolism and disorders
University of Pittsburgh
2018-2025
Children's Hospital of Pittsburgh
2018-2025
University of Pittsburgh Medical Center
2023
Cohen Children's Medical Center
2021
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2021
Schneider Children's Hospital
2021
UCSF Benioff Children's Hospital
2018
University of California, San Francisco
2018
Centers for Disease Control and Prevention
2018
Pennsylvania Department of Health
2018
Thrombosis and inflammation are intimately linked synergistically contribute to the pathogenesis of numerous thromboinflammatory diseases, including sickle cell disease (SCD). While platelets central thrombogenesis inflammation, molecular mechanisms crosstalk between 2 remain elusive. High-mobility group box 1 (HMGB1) regulates stimulates platelet activation through Toll-like receptor 4. However, it remains unclear whether HMGB1 modulates other thrombotic agonists regulate activation....
ABSTRACT Background Management of neonatal portal vein thrombosis (PVT), a relatively common type pediatric deep thrombosis, is not completely standardized. Questions remain about the benefit anticoagulation (ATC) therapy and optimal frequency duration doppler ultrasound (US) surveillance for liver complications such as hypertension gastrointestinal bleeding. Current guidelines suggest reserving ATC only occlusive PVT, highlighting need explicit grading PVT in radiologic reports consensus...
Abstract Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated strains. We describe a case in which nongroupable strain, rarely causes disease healthy persons, caused fatal recipient despite vaccination.
Hemolysis, a pathological component of many diseases, is associated with thrombosis and vascular dysfunction. Hemolytic products, including cell-free hemoglobin free heme directly activate platelets. However, the effect hemolysis on platelet degranulation, central process in not only thrombosis, but also inflammatory mitogenic signaling, remains less clear. Our group showed that hemoglobin-induced activation involved production mitochondrial reactive oxygen species (mtROS). molecular...
A healthy 2-year-old male with a history of mild persistent asthma visited the outpatient hematology clinic to evaluate intermittent epistaxis. There was no recent illness. His exam notable for left upper extremity bruising secondary venipuncture, but lymphadenopathy or hepatosplenomegaly. Complete blood count (CBC) revealed hemoglobin 9.3 g/dL, leukocyte 20.7 109/L, and platelet 33 k 109/L. Peripheral smear exhibited polychromasia, numerous large platelets, few reactive lymphocytes. The...
Children with malignant mediastinal masses have increased thrombotic events (TE). Eligible subjects between January 2000 and December 2017 were evaluated for TE, 19 among 76 receiving enoxaparin thromboprophylaxis. There 13 TEs an incidence of 17.1%. Mediastinal compression directly led to TE in 9.2% who also had statistically significant superior vena cava at diagnosis. Primary thromboprophylaxis did not significantly affect occurrence; however, larger studies are warranted consider...
Background: Light transmission aggregometry (LTA) has been the gold standard test for evaluation and diagnosis of platelet function disorders (PFD).The high plasma volume required LTA can hinder assessment children.Whole blood impedance lumiaggregometry (WBILA) utilizes a smaller but there is paucity literature comparing these methodologies in children.Further, limited information on presenting bleeding symptoms their correlation with PFD pediatric patients.Comparison testing modalities may...
Abstract Thrombosis and inflammation are intimately linked synergistically contribute to the pathogenesis of a number vascular diseases. On cellular level, while platelet is central thrombus formation as well an active mediator inflammation, molecular mechanisms cross-talk between thrombosis remain elusive. High-Mobility Group Box 1 protein (HMGB1) inflammatory regulator that also stimulates activation through its interaction with toll-like receptor 4 (TLR4). However, it remains unclear...
Abstract Hemolysis is a pathological component of many diseases and associated with thrombosis vascular dysfunction. Hemolytic products, including cell-free hemoglobin free heme directly activate platelets. However, the effect hemolysis on platelet degranulation, central process in not only thrombosis, but also inflammatory mitogenic signaling, remains less clear. Our group showed that hemoglobin-induced activation involved production mitochondrial reactive oxygen species (mtROS). molecular...
Children with malignant mediastinal masses have increased thrombotic events (TE). We examined primary thromboprophylaxis in reducing TE. Eligible subjects were started on enoxaparin and compared to a cohort without. There 15 TEs among 76 for an incidence of 19.7%. Mediastinal compression directly led TE, (M-TE) 9.2% requiring 2-fold longer duration therapeutic anticoagulation. Primary revealed trend towards reduction M-TE although not statistically significant. The had greater superior vena...