A5034383757- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chemotherapy-induced cardiotoxicity and mitigation
- Glioma Diagnosis and Treatment
- Pharmaceutical studies and practices
- Blood Coagulation and Thrombosis Mechanisms
- Neuroblastoma Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Parvovirus B19 Infection Studies
- Hemophilia Treatment and Research
- Ethics and Legal Issues in Pediatric Healthcare
- Heparin-Induced Thrombocytopenia and Thrombosis
- Histiocytic Disorders and Treatments
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Obstructive Sleep Apnea Research
- Health, psychology, and well-being
Children's Hospital of Pittsburgh
2013-2025
University of Pittsburgh
2007-2025
University of Pittsburgh Medical Center
2011-2023
Pittsburg State University
2021
St. Jude Children's Research Hospital
2017
Children's Minnesota
2017
Children's Oncology Group
2006-2017
City Of Hope National Medical Center
2012-2017
City of Hope
2012-2017
University of North Texas
2017
This study examined whether chronic stress impairs the immune system's capacity to respond hormonal signals that terminate inflammation. Fifty healthy adults were studied; half parents of cancer patients, and children. Parents patients reported more psychological distress than They also had flatter diurnal slopes cortisol secretion, primarily because reduced output during morning hours. There was evidence impaired response anti-inflammatory signals: The a synthetic glucocorticoid hormone...
This study examined whether chronic stress impairs the immune system's capacity to respond hormonal signals that terminate inflammation.Fifty healthy adults were studied; half parents of cancer patients, and children.Parents patients reported more psychological distress than children.They also had flatter diurnal slopes cortisol secretion, primarily because reduced output during morning hours.There was evidence impaired response anti-inflammatory signals: The a synthetic glucocorticoid...
Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis these We examined whether single nucleotide polymorphisms (CBR1 1096G>A) and/or (CBR3 V244M) modified the dose-dependent risk anthracycline-related cardiomyopathy childhood cancer survivors.One hundred seventy survivors with (patient cases) were compared 317 no (controls; matched on diagnosis, year length follow-up, race/ethnicity) using...
Systemic exposure to mercaptopurine (MP) is critical for durable remissions in children with acute lymphoblastic leukemia (ALL). Nonadherence oral MP could increase relapse risk and also contribute inferior outcome Hispanics. This study identified determinants of adherence described impact on relapse, both overall by ethnicity.
Variability in prescribed doses of 6-mercaptopurine (6MP) and lack adherence to a 6MP treatment regimen could result intra-individual variability systemic exposure (measured as erythrocyte thioguanine nucleotide [TGN] levels) children with acute lymphoblastic leukemia (ALL). The effect on relapse risk this is unknown.To determine the high ALL.We used prospective longitudinal design (Children's Oncology Group study [COG-AALL03N1]) monitor disease 742 ALL ambulatory care settings 94...
PURPOSE: Isolated meningeal relapse in children with acute lymphoblastic leukemia (ALL) usually has been followed by bone marrow and limited survival. The purpose of this study was to prevent administering intensive therapy before delayed craniospinal radiation. PATIENTS AND METHODS: Eighty-three patients ALL first remission an isolated CNS were treated systemic chemotherapy known enter into the CSF intrathecal for 6 months. Craniospinal irradiation (24 Gy cranial/15 spinal) then...
Purpose Prognosis and outcome of children with isolated CNS relapse acute lymphoblastic leukemia (ALL) has depended on duration first complete remission (CR1). This study intensified systemic therapy by delaying radiation for 12 months tailored CR1 duration. Patients Methods Seventy-six ALL were treated chemotherapy that effectively penetrates into the CSF intrathecal months. less than 18 received craniospinal (24 Gy cranial/15 spinal), whereas those or more cranial only (18 Gy), followed...
ABSTRACT Background Management of neonatal portal vein thrombosis (PVT), a relatively common type pediatric deep thrombosis, is not completely standardized. Questions remain about the benefit anticoagulation (ATC) therapy and optimal frequency duration doppler ultrasound (US) surveillance for liver complications such as hypertension gastrointestinal bleeding. Current guidelines suggest reserving ATC only occlusive PVT, highlighting need explicit grading PVT in radiologic reports consensus...
Abstract BACKGROUND: Since 1975, there has been a dramatic increase in the survival rates of pediatric and older cancer patients, but adolescent young adult (AYA) patients ages 15 to 40 years have not had similar improvement. Data indicate direct correlation between increased cure clinical trial enrollment. METHODS: The authors previously published data indicating inferior enrollment when AYA were treated at an oncology center versus center. To address this deficit, joint Oncology Program...
Erwinia asparaginase is antigenically distinct from E.coli-derived and may be used after hypersensitivity. In a single-arm, multicenter study, we evaluated nadir serum activity (NSAA) toxicity with intravenously administered chrysanthemi (IV-Erwinia) in children adolescents acute lymphoblastic leukemia (ALL) or lymphoma hypersensitivity to asparaginase.Between 2012 2013, 30 patients (age 1-17 years) enrolled 10 centers. Patients received IV-Erwinia, 25,000 IU/m(2)/dose on...
Over the last 30 years significant strides have been made in cure rates for children with cancer, but these improvements not seen adolescents and young adults. The reasons this lack of progress are multifactorial, it is clear greater correlated controlled clinical trials. Our objective was to see if pediatric patients over age 15 had a lower rate trial enrollment, so, why.We retrospectively analyzed data on all new oncology diagnoses at Children's Hospital Pittsburgh (CHP) diagnosed 5-year...
Etude pilote sur 21 enfants de 6 mois a 13 ans atteints purpura thrombopenique idiopathique (PTI) avec un taux plaquettes inferieur 20000/μl, traites par 3 doses 30 mg/kg methylprednisolone. Resultat efficace les plaquettes, peu couteux, toxique, comparer prospectivement gamma-globulaires et steroides oraux
Background and Objectives. Chronic, severe iron-deficiency anemia (IDA) in the first years of life increases risk irreversibly compromised cognitive, affective, motor development. While IDA infants has decreased because dietary changes (iron-fortified formula delaying cow’s milk), toddlers (13-36 months) are equally vulnerable to adverse effects IDA. We aimed show that despite public health efforts, remains a problem is associated with excess milk consumption. Methods. Retrospective chart...
Purpose Children with acute lymphoblastic leukemia (ALL) are generally instructed to take mercaptopurine (6-MP) in the evening and without food or dairy products. This study examines association between 6-MP ingestion habits adherence, red cell thioguanine nucleotide (TGN) levels, risk of relapse children TMPT wild-type genotype. Methods Participants included 441 ALL receiving oral for maintenance. Adherence was monitored over 48,086 patient-days using Medication Event Monitoring System;...
Obesity correlates with adverse events (AEs) in children acute myelogenous leukemia and during maintenance therapy for lymphoblastic (ALL). Less is known about AEs obese ALL patients pre-maintenance chemotherapy. We evaluated the relationship between obesity (body mass index (BMI) ≥ 95th percentile) chemotherapy pediatric ALL.One hundred fifty-five diagnosed at a single institution 2006 2012 were retrospectively infections, treatment-requiring hypertension, insulin-requiring hyperglycemia,...
The American Society of Pediatric Otolaryngology recommends pre-operative coagulation testing only when indicated by history or physical exam. Nevertheless, many surgeons test all children scheduled for tonsillectomy and/or adenoidectomy (T&A). Studies screening have had conflicting results. A decision analysis model was constructed to address the costs and health outcome states strategies in children.A 14-day Markov evaluated three strategies: (1) disorders; (2) those with a pertinent...
We evaluated the prevalence of hemostatic disorders among pediatric patients with abnormal screening coagulation tests.We analyzed 48 consecutive referrals for prothrombin times, partial thromboplastin or closure times obtained as preprocedural screens. Patients were by uniform diagnostic testing.Seventeen (35%) had an isolated nonspecific inhibitor (NSI). Six (12.5%) presented mildly low factor activity a concomitant NSI. These deficiencies unclear clinical significance. One patient (2%)...
Abstract Background Treatment choice in pediatric immune thrombocytopenia (ITP) is arbitrary, because few studies are powered to identify predictors of therapy response. Increasingly, rituximab becoming a treatment those refractory other therapies. Methods The objective this study was evaluate univariate and multivariable platelet count response rituximab. After local IRB approval, 565 patients with chronic ITP enrolled met criteria for the longitudinal, North American Chronic Registry...
Obesity at diagnosis of childhood acute lymphoblastic leukemia (ALL) is associated with greater risk relapse; whether this association extends to obesity during maintenance unstudied.
Little is known about cisplatin ototoxicity in pediatric patients. Measurement of otoacoustic emissions a rapid, reproducible, objective method evaluating hearing. We examined whether transient-evoked patients exposed to the past correlated with audiographic findings. Twelve were entered into study (mean age at treatment 7.8 years, mean cumulative dose 442.5 mg/mm2, 7.1 doses). Hearing 3000 Hz was preserved 82.6% In higher frequencies significant sensorineural hearing loss noted: 43.5% 4...
Abstract Background The primary objective in the treatment of acute pediatric idiopathic thrombocytopenic purpura (ITP) is to rapidly increase platelet count. Methods We built a decision analytic model evaluate cost‐utility four commonly used strategies: intravenous immunoglobulin G (IVIG) 0.8 g/kg, anti‐D 75 mcg/kg, methylprednisolone (30 mg/kg for 3 days), and prednisone (4 mg/kg/day 4 days). In our baseline model, all children were hospitalized upon presentation, discharged once count...