Michele P. Lambert
A5034517358- Platelet Disorders and Treatments
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Genomics and Rare Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Congenital heart defects research
- Venous Thromboembolism Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Renal Diseases and Glomerulopathies
- Blood Coagulation and Thrombosis Mechanisms
- Congenital Heart Disease Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myeloid Leukemia Research
- Erythrocyte Function and Pathophysiology
- Autoimmune and Inflammatory Disorders Research
- Neonatal Health and Biochemistry
- Hemophilia Treatment and Research
- COVID-19 Clinical Research Studies
Children's Hospital of Philadelphia
2016-2025
Justus-Liebig-Universität Gießen
2025
University of Pennsylvania
2015-2024
Philadelphia University
2020-2023
University of Wisconsin–Madison
2023
Pediatrics and Genetics
2013-2022
Society for Classical Studies
2021
Pennsylvania State University
2020
National Institute for Health Research
2017
University of Cambridge
2017
BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2) pandemic described children as being less susceptible to disease 2019 (COVID-19) than adults. Subsequently, a and novel pediatric disorder termed multisystem inflammatory syndrome in (MIS-C) emerged. We report on unique hematologic immunologic parameters that distinguish between COVID-19 MIS-C provide insight into pathophysiology.
Cases of apparent secondary immune thrombocytopenia (ITP) after SARS-CoV-2 vaccination with both the Pfizer and Moderna versions have been reported reached public attention. Public alarm was heightened following death first identified patient from an intracranial hemorrhage, which on Internet, then in USA Today1 The New York Times.2 Described below, we collected a series cases very low platelet counts occurring within 2 weeks order to enhance our understanding possible relationship, if any,...
Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic disorder associated with a severe prothrombotic state. We investigated whether neutrophils and neutrophil extracellular traps (NETs) contribute to the development of thrombosis in HIT. Using endothelialized microfluidic system murine passive immunization model, we show that HIT induction leads increased adherence venous endothelium. In mice, endothelial enhanced immediately downstream nascent thrombi, after which...
22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by recurrent, chromosome‐specific, low copy repeat (LCR)–mediated copy‐number losses of chromosome 22q11. The Children's Hospital Philadelphia has been involved in the clinical care individuals with what now known as 22q11.2DS since our initial report association DiGeorge 1982. We reviewed medical records on continuously growing longitudinal cohort 1,421 patients molecularly confirmed from 1992 to 2018. Most are Caucasian and older...
E527K hyperactive SRC results in megakaryocytes with increased podosome formation, thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
Abstract Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild or minimal disease, a small proportion developing disease multisystem inflammatory in (MIS-C). Complement-mediated thrombotic microangiopathy (TMA) has been associated SARS-CoV-2 adults but not studied the pediatric population. We hypothesized that complement activation plays an important role and sought to understand if TMA was present these patients. enrolled 50 hospitalized...
Excessive bleeding at surgery is a feared complication in patients with inherited platelet disorders. However, very few studies have evaluated the frequency of surgical these hemorrhagic We performed worldwide, multicentric, retrospective study to assess complications surgery, preventive and therapeutic approaches adopted, their efficacy disorders: Surgery Platelet disorders And Therapeutic Approach (SPATA) study. rated outcome 829 procedures carried out 423 well-defined forms 238 function...
Abstract Mg 2+ plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg ] i megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is ubiquitous, constitutively active cation with cytosolic α-kinase domain that critical embryonic development cell survival. Here we report impaired function of TRPM7 MKs causes...
Multi-system Inflammatory Syndrome in Children (MIS-C) is a major complication of Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) infection pediatric patients. Weeks after an often mild or asymptomatic initial with SARS-CoV-2 children may present severe shock-like picture and marked inflammation. MIS-C varying degrees cardiovascular hyperinflammatory symptoms. Here we perform comprehensive analysis the plasma proteome more than 1400 proteins SARS-CoV-2. We hypothesize that would reflect...
To study the biology and identify markers of severe cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment.We used comprehensive proteomic profiling to measure over 1,400 serum proteins at multiple serial timepoints a cohort patients with B-cell acute lymphoblastic leukemia treated CD19-targeted CAR T CTL019 on two clinical trials.We identified fms-like tyrosine kinase 3 (FLT3) mast cell...