A5088339167- Hematopoietic Stem Cell Transplantation
- Entomological Studies and Ecology
- Lepidoptera: Biology and Taxonomy
- Retinal Development and Disorders
- Hymenoptera taxonomy and phylogeny
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Circadian rhythm and melatonin
- T-cell and B-cell Immunology
- Hematological disorders and diagnostics
- Advanced Radiotherapy Techniques
- Orthoptera Research and Taxonomy
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Erythrocyte Function and Pathophysiology
- Cancer, Stress, Anesthesia, and Immune Response
- Hemoglobinopathies and Related Disorders
- Dietary Effects on Health
- Radiation Therapy and Dosimetry
- Single-cell and spatial transcriptomics
- Medical History and Research
Cincinnati Children's Hospital Medical Center
2018-2025
Children's Medical Center
2018-2024
University of Cincinnati Medical Center
2019-2024
University of Arizona
1979-2023
University of Michigan
2014-2017
Albert Einstein College of Medicine
2010-2017
Accuray (United States)
2015-2017
Organogenesis (United States)
2017
ETH Zurich
2016
Centro Nacional de Biotecnología
2005-2014
L-Glutamic acid and its sodium salt have been widely used in the oral treatment of petit mal mental deficiency (e. g., Zimmerman, Burgemeister, Putnam, 1949; Milliken Standen, 1951). Single doses 20-30 gm. also administered intravenously without permanent illeffects (Sapirstein, 1943; Elman, 1946; Mayer-Gross Walker, Weil-Malherbe, 1949). During an investigation influence various substances biochemical importance upon progress mouse hereditary retinal dystrophy it was observed that...
Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear phagocytes modulate HSC niche. We defined three populations of BM that include Gr-1hi monocytes (MOs), Gr-1lo MOs, and macrophages (MΦ) based on differential expression Gr-1, CD115, F4/80, CD169. Using MO MΦ conditional depletion models, found reductions led to reduced CXCL12 levels, selective down-regulation retention...
The bone marrow adjusts blood cell production to meet physiological demands in response insults. spatial organization of normal and stress responses are unknown owing the lack methods visualize most steps production. Here we develop strategies image multipotent haematopoiesis, erythropoiesis lymphopoiesis mice. We combine these with imaging myelopoiesis
Abstract Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression function of the patterning transcription factor, Hoxa11, in progenitor-enriched MSCs. Here, using a newly generated Hoxa11-CreER T2 lineage-tracing system, we show Hoxa11 -lineage marked give...
The developing peripheral nervous and immune systems are functionally distinct from those of adults. These vulnerable to early-life injury, which influences outcomes related nociception following subsequent injury later in life (i.e., "neonatal nociceptive priming"). underpinnings this phenomenon unclear, although previous work indicates that macrophages trained by inflammation injury. Our findings show both necessary partially sufficient drive neonatal priming, possibly due a long-lasting...