A5086233828- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Mercury impact and mitigation studies
- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Heavy Metal Exposure and Toxicity
- Erythrocyte Function and Pathophysiology
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Heavy metals in environment
- Single-cell and spatial transcriptomics
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetics and Neurodevelopmental Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Periodontal Regeneration and Treatments
- Platelet Disorders and Treatments
- Dental Implant Techniques and Outcomes
Cincinnati Children's Hospital Medical Center
2018-2025
Guangzhou Medical University
2023-2024
Hefei First People's Hospital
2024
Institute of Geochemistry
2020-2024
University of Chinese Academy of Sciences
2020-2024
Chinese Academy of Sciences
2015-2024
China University of Geosciences
2024
Stomatology Hospital
2017-2023
Guangdong Pharmaceutical University
2014-2023
Chongqing Medical University
2018-2023
The bone marrow adjusts blood cell production to meet physiological demands in response insults. spatial organization of normal and stress responses are unknown owing the lack methods visualize most steps production. Here we develop strategies image multipotent haematopoiesis, erythropoiesis lymphopoiesis mice. We combine these with imaging myelopoiesis
Several studies have focused on cold tolerance in multiple regulated levels. However, a genome-scale molecular analysis of the network under control transcription factors (TFs) is still lacking, especially for trees. To comprehensively identify TFs that regulate stress response paper mulberry and understand their regulatory interactions, transcriptomic data was used to assess changes gene expression induced by exposure cold. Results indicated 794 TFs, belonging 47 families comprising more...
The gap in knowledge of the molecular mechanisms underlying differentiation human pluripotent stem cells (hPSCs) into mesenchymal cell lineages hinders application hPSCs for cell-based therapy. In this study, we identified a critical role muscle segment homeobox 2 (MSX2) initiating and accelerating program that leads to stem/stromal (MSC) from hPSCs. Genetic deletion MSX2 impairs hPSC MSCs. When aided with cocktail soluble molecules, ectopic expression induces form nearly homogeneous fully...
Rice paddies are agricultural sites of special concern because the potent toxin methylmercury (MeHg), produced in rice paddy soils, accumulates grains. MeHg cycling is mostly controlled by microbes but their importance production and degradation soils across a Hg concentration gradient remains unclear. Here we used surface rhizosphere soil samples series incubation experiments combination with stable isotope tracers to investigate relative different microbial groups on contamination...
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Selenium (Se) serves as a natural detoxifier for the typical toxic heavy metal mercury (Hg), and interactions between Se Hg have attracted considerable scholarly attention in field of Hg. However, there is currently lack systematic summaries discussions about Se–Hg soil–plant systems. This study summarizes microscopic processes macroscopic manifestations by exploring their characteristics, occurrence mechanisms, revealing dual-pump driving mechanism that emphasizes "soil-root"...
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic using defined transcription factors, are regarded as a promising cell source for tissue engineering. For the purpose of bone regeneration, efficient in vitro differentiation iPSCs into downstream cells, such mesenchymal (MSCs), osteoblasts, or osteocyte-like before use is necessary to limit undesired tumorogenesis associated with pluripotency iPSCs. Until recently numerous techniques on production iPSC-derived osteogenic...
Dental pulp stem cells (DPSC) have shown osteogenic and bone regenerative potential. Improving the in situ regeneration potential of DPSC is crucial for their application as seed during defect reconstruction clinics. This study aimed to develop DPSC-derived organoid-like microspheroids effective seeds tissue engineering applications. (70 μm diameter) were cultured a polydimethylsiloxane-mold-based agarose-gel microwell-culture-system with or without cannabidiol (CBD)-treatment. Results vitro...
Intangible cultural heritage (ICH) is a significant resource for integrating culture and tourism an essential content of development. This research used eye-tracking experiment, retrospective oral report, questionnaire survey to collect tourists' objective eye movement data subjective preference ICH. Results indicated difference in visual attention different categories Tourists put most on ICH folk customs skills. Moreover, character, culture, life elements are main focus. Findings from the...
Long non-coding RNAs (lncRNAs), a type of epigenetic regulator, are thought to play important roles in embryonic development mice, and several developmental defects associated with modification disorders. The most dramatic reprogramming event occurs during somatic cell nuclear transfer (SCNT) when the expression profile differentiated is abolished, newly embryo-specific established. However, molecular mechanism underlying remains unclear, dynamics functions lncRNAs this process have not yet...
Human globin gene production transcriptionally “switches” from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription cis elements scattered throughout the locus. The DRED (direct repeat erythroid-definitive) repressor recruited ε-globin γ-globin promoters orphan nuclear receptors TR2 (NR2C1) TR4 (NR2C2) engender their silencing in erythroid cells. Here we found receptor corepressor-1 (NCoR1) a critical component of...
Mammal embryos can be impaired by mother's excessive ethanol uptake, which induces a higher level of reactive oxygen species (ROS) and interferes in one carbon unit metabolism. Here, our analysis vitro culture system reveals immediate effect medium on mouse embryo development presents concentration dependent. A preimplantation using contained 1% could impact greatly early development, harmful would last during the whole period including reducing ratio blastocyst formation implantation,...
Induced pluripotent stem cell (iPSC)-derived mesenchymal cells (iMSCs) are a promising source for bone tissue engineering. However, iMSCs have less osteogenic potential than BMSCs, and the classical iPSC-EB-iMSC process to derive from iPSCs is too laborious as it involves multiple in vitro steps. Low-intensity pulsed ultrasound (LIPUS) safe therapeutic modality used promote differentiation of cells. Whether LIPUS can facilitate simplify unknown. We stimulated with at different output...
Selenium (Se) is an essential trace element that plays a crucial role in maintaining the health of humans, animals, and certain plants. It extensively present throughout Earth's crust absorbed by crops form selenates selenite, eventually entering food chain. Se biofortification agricultural process employs agronomic genetic strategies. Its goal to enhance mechanisms crop uptake accumulation exogenous Se, resulting production enriched with Se. This ultimately contributes promoting human...
Idiopathic aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. Immune abnormalities such as decreased lymphocyte counts, inverted CD4/CD8 T-cell ratio and increased IFN-γ-producing T cells have been found in AA. CD30, a surface protein belonging to the tumor necrosis factor receptor family releasing from cell soluble form (sCD30) after activation, marks subset of activated secreting IFN-γ when exposed allogeneic antigens. Our study elevated BM plasma levels sCD30...