Inter-fraction variations during radiotherapy pose a challenge for cervical cancer patients, highlighting the benefits of online adaptive (oART). However, adaptation decisions rely on subjective image reviews by physicians, leading to high inter-observer variability and inefficiency. This study explores feasibility using artificial intelligence (AI) decision-making in oART. A total 24 patients with who underwent 671 fractions daily fan-bean computed tomography (FBCT)-guided oART were...

Summary Background The 5-year survival rate for extensive-disease small-cell lung carcinoma (ED-SCLC) is only 1%. Recently, apatinib exerted promising effects on cancer patients after failure of first-line chemotherapy. Methods This study enrolled 24 ED-SCLC to the efficacy and toxicity in combination with chemotherapy maintenance therapy. primary endpoints were overall (OS) progression-free (PFS). secondary included safety. Apatinib was given 250 mg/day during interval, as therapy 4–6...

Several materials are utilized in the production of bolus, which is essential for superficial tumor radiotherapy. This research aimed to compare variations dose deposition deep tissues during electron beam radiotherapy when employing different bolus materials. Specifically, study developed general models (S-T models) and postoperative breast cancer (P-B models). Each model comprised a made water, polylactic acid (PLA), polystyrene, silica-gel or glycerol. Geant4 was employed simulate...

ABSTRACT Objective In this study, we investigated the application value of bronchoalveolar lavage fluid (BALF) combined with targeted next‐generation sequencing (tNGS) in pathogen detection‐based diagnosis patients lung infections. Method A retrospective analysis was conducted on who underwent tracheoscopy and conventional microbiological tests (CMTs) BALF, coupled metagenomic (mNGS) or tNGS. This investigation encompassed individuals suspected infections at Tianjin First Central Hospital...

Abstract Objective To investigate the safety and feasibility of sleeve resection under Uni-VATS following neoadjuvant chemotherapy combined with immunotherapy for locally advanced central-type non-small cell lung cancer(NSCLC). Methods We analyzed 10 cIIB-IIIB NSCLC patients who underwent single-port thoracoscopy from December 2022 to August 2023 after receiving platinum-based albumin paclitaxel programmed death protein-1 (PD-1) inhibitor drugs. Perioperative clinical data, side effects...

Overexpression of epidermal growth factor receptor can be found in more than 80% patients with locoregionally advanced nasopharyngeal carcinoma and is associated shorter survival. In this work, we evaluated the feasibility adding nimotuzumab to chemoradiation carcinoma. Twenty-three clinically staged T3-4 or any node-positive disease were enrolled. They scheduled receive one cycle induction chemotherapy followed by intensity-modulated radiotherapy, weekly administration concurrent...

Objective: To evaluate the impact of systematic nutrition management (SNM) on nutritional status, treatment-related toxicity, quality life (QoL), response rates, and survival in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) treated by radiotherapy (RT). Methods: In this retrospective study, 56 LA-NPC were selected as group (NG) for SNM during RT till 1 month later. Another receiving without control (CG) identified from hospital database matched pairs NG according to age,...

Esophageal squamous cell carcinoma (ESCC) is the most prevalent form of esophageal cancer in China and closely associated with malignant biological characteristics poor survival. Ferroptosis a newly discovered iron-dependent mode death that plays an important role behavior ESCC cells. The clinical significance ferroptosis-related long noncoding RNAs (FRLs) remains unknown warrants further research. current study obtained RNA sequencing profiles corresponding data from Cancer Genome Atlas...

Abstract The aim of this study was to investigate the in vitro effects and regulatory mechanism CGRP (calcitonin gene‐related peptide) on NO (nitric oxide) production osteoblasts. MOB (primary human mandibular osteoblasts) osteoblast‐like cells (MG‐63) were either cultured with or co‐incubated inhibitors targeting eNOS (endothelial nitric oxide synthase), iNOS (inducible nNOS (neuronal synthase) [Ca 2+ ] i (intracellular Ca ). concentration cell culture supernatants measured during first 24...

Abstract We have investigated the in vitro effects and regulatory mechanism of CGRP (calcitonin gene‐related peptide) on differentiation OB (osteoblasts) co‐culture with HUVEC (human umbilical vein endothelial cells). Primary human MOB (mandibular OB) OB‐like cells (MG‐63) were either cultured directly or indirectly co‐cultured at a 1:1 ratio. Expression OC (osteocalcin) was measured by ELISA, expression ALP (alkaline phosphatase) collagen mRNA quantitative fluorescent PCR. For...

Tumor-infiltrating lymphocytes (TILs) play a crucial role in anti-tumor immunity. Basic studies have found that stimulator of interferon genes (STING), activated by sensing DNA damage, plays recruiting and activating TILs tumors. However, the correlation between base excision repair (BER) pathway, STING pathway TILS their effect on prognosis upper urinary tract urothelial carcinoma (UTUC) are still unclear. The aim this study was to investigate prognostic those proteins expression for...

Abstract Background To explore the efficacy and safety of Transcatheter rectal arterial chemoembolization with oxaliplatin S-1 concurrent chemoradiotherapy as neoadjuvant therapy for locally advanced cancer. Methods This s a prospective, monocentric, non-randomized clinical study, total 95 patients were enrolled assigned to two groups: an investigational group ( n = 50) receiving transcatheter (TRACE) preoperative radiotherapy plus chemotherapy (NATRACE-CRT), followed by surgery, control 45)...

Abstract Background It was demonstrated that multifunctional protein APE1 (Apurinic/apyrimidinic endonuclease 1) is closely related to tumor immune microenvironment in a number of investigations, Meanwhile, the abundance infiltrating lymphocytes (TILs) has been shown as prognosis indicator some researches. However, it remains unclear whether involved process TILs affecting patients. To this end, we investigated associations between and non-small cell lung cancer (NSCLC) explored would...

Objective: This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients locally advanced nasopharyngeal carcinoma (LA-NPC). Patients methods: A total 50 newly diagnosed LA-NPC treated at Affiliated Hospital Jiangnan University between November 2011 January 2017 were retrospectively analyzed. All received combined treatment modality IMRT. Nimotuzumab was administered concurrently...

In this study, the radiation-enhancing effects of combined treatment with nimotuzumab, a humanized EGFR-blocking antibody, and celecoxib, COX-2 selective inhibitor, in human nasopharyngeal carcinoma (NPC) cells were investigated.3-(4,5-Dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide clonogenic survival assays done to evaluate cytotoxic radiosensitizing nimotuzumab or celecoxib combination on CNE1 CNE2 cells. Western blot analysis was performed identify effect and/or without irradiation...

Abstract Background Although much progress has been made in the diagnosis of early-stage lung adenocarcinoma (ES-LUAD), prognosis for ES-LUAD patients with rapid recurrence is still poor. Importantly, there currently no effective and precise method to screen who may develop recurrence. Therefore, it necessary identify potential differentially expressed genes (DEGs) non-rapid Methods Affymetrix GeneChip Human Transcriptome Array was used DEGs between Rapid defined as recurrence-free survival...

Abstract Background and Objectives To analyze evaluate the impact of preoperative transcatheter rectal arterial chemoembolization (TRACE) with concurrent chemoradiotherapy on surgery prognosis locally advanced cancer (LARC). Methods A total 118 patients LARC were enrolled in this nonrandomized prospective study. They assigned into experimental group receiving TRACE (TRACE‐CRT group, N = 60) control only neoadjuvant (CRT 58). All underwent after their treatments. Results successfully...

BACKGROUND Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results high-risk MM with limited treatment alternatives. Thus, there an urgent need for identification validation potential treatments this subtype. Microarray data sequencing information from public databases could offer opportunities discovery new...

Objective:The purpose of this study was to evaluate the efficacy two radiotherapy techniques for breast cancer patients with post-mastectomy.The intensity-modulated treating chest wall and regional nodes contoured as a whole planning target volume compared conventional segmented 3-dimensional conformal undergoing modified radical mastectomy.Materials methods: Patients who received post-mastectomy radiation therapies were retrospectively analyzed.The supra/infraclavicular region +/-internal...

Breast cancer (BC) is the most commonly diagnosed and second leading cause of cancer-related death in women worldwide. Ferroptosis, an iron-dependent newly discovered mode cell death, can be induced by lenaltinib plays important role biological behaviors BC. Therefore, prognostic value ferroptosis-related genes (FRGs) BC warrants further investigation. FRG expression profiles clinical data were downloaded from The Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO)....

Aim: To compare treatment outcomes of total neoadjuvant therapy (TNT) and the standard for locally advanced rectal cancer (LARC). Materials & methods: Patients with LARC (cT2-4 and/or cN1-2) who were treated preoperative chemoradiotherapy plus induction consolidation chemotherapy followed by surgery or recruited. Pathologic complete response (pCR) rate, overall survival, disease-free survival sphincter preservation rate as well safety evaluated. Results: 49 cases TNT 71 received treatment....