A5100343343- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Prenatal Screening and Diagnostics
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Insect symbiosis and bacterial influences
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Folate and B Vitamins Research
- Virology and Viral Diseases
- Gut microbiota and health
- Erythropoietin and Anemia Treatment
- Nuclear Receptors and Signaling
- Glutathione Transferases and Polymorphisms
- Genetics and Physical Performance
- Scoliosis diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Genomics, phytochemicals, and oxidative stress
- Cleft Lip and Palate Research
- Biochemical Acid Research Studies
Second Affiliated Hospital of Shantou University Medical College
2025
Shantou University
2025
Harbin Medical University
2011-2025
Fourth Affiliated Hospital of Harbin Medical University
2025
Mongolian National University of Medical Sciences
2024
University of Hong Kong
2023-2024
University of Hong Kong - Shenzhen Hospital
2023-2024
Zhejiang University
2000-2024
Affiliated Hospital of Qingdao University
2024
Huazhong University of Science and Technology
2024
Abstract Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations also confer malignant characters human cells by antioxidative/detoxifying enzymes and metabolic reprogramming. In this study, we examined how these contradictory activities of Nrf2, cancer chemoprevention cell growth enhancement, can be reconciled an established mouse model urethane-induced lung carcinogenesis. Using Keap1-knockdown (kd) mice, which express high levels found...
Significance Brown and beige fat function has important implications for metabolic physiology the treatment of disorders. How transcription factors interface with long noncoding RNAs (lncRNAs), an emerging class regulatory factors, to drive development thermogenesis brown/beige remains essentially unknown. Here we identified Zbtb7b as activator thermogenic gene program through a genome-wide functional screen showed that it plays essential role in cold-induced formation. Mechanistically,...
Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, microbiota modulation with probiotic bacteria, such as Saccharomyces boulardii, constitutes promising therapy for hepatosis. In this study, we aimed to investigate the protective effects of S. boulardii on D-Galactosamine-induced injury mice. Liver function test and histopathological analysis both suggested can be effectively attenuated by administration. meantime, induced dramatic changes...
Placental activation of the renin-angiotensin system (RAS) plays a key role in pathogenesis preeclampsia. Reactive oxygen species (ROS) are thought to affect placental angiogenesis, which is critical for preventing preeclampsia pathology. We examined ROS by genetically modifying Keap1-Nrf2 pathway, cellular antioxidant defense system, mouse model RAS-induced Nrf2 deficiency would be expected impair responses; however, preeclamptic mice improved maternal and fetal survival, ameliorated...
Changes in intestinal microecology during acute liver failure (ALF) directly affect the occurrence and development of disease. The study aimed to investigate relationship between microbiota key immune cells. Fecal transplantation (FMT) was used determine whether ALF can balance Th17/Treg cytokines. gut clinical indicators analyzed. BALB/c mice were treated with D-galactosamine (D-GalN) induce a murine model. FMT D-GalN conducted test for function indicators. Results showed that proportions...
Nickel (Ni) compounds are potent carcinogens and can induce malignant transformation of rodent human cells. To uncover the molecular mechanisms nickel sulfide (NiS)-induced cell transformation, we investigated epigenetic alterations in a set DNA repair genes. The silencing O(6)-methylguanine methyltransferase (MGMT) gene locus upregulation 1 (DNMT1) expression was specifically detected NiS-transformed bronchial epithelial (16HBE) In addition, noted including hypermethylation, reduced histone...
The mucosal lining of the small intestine is a complex epithelium that continually renewed by division stem cell population located in intestinal crypts, migration daughter cells along villus, and, finally, extrusion senescent into lumen. majority both crypt and villus compartments are enterocytes acquire differentiated functions as they migrate out crypt. Sucrase-isomaltase (SI) an enterocyte-specific, brush-border enzyme has little activity maximal low mid cells. mechanism which SI...
Hepatic gluconeogenesis is important for maintaining steady blood glucose levels during starvation and through light/dark cycles. The regulatory network that transduces hormonal circadian signals serves to integrate these physiological cues adjust synthesis secretion by the liver. In this study, we identified ubiquitin-specific protease 2 (USP2) as an inducible regulator of hepatic responds nutritional status clock. Adenoviral-mediated expression USP2 in liver promotes production exacerbates...
Neutrophil extracellular traps (NETs) released by neutrophils are crucial for cancer development, metastasis, and can indicate gastric (GC) patients' prognosis. This study reveals the relevance of NETs-related genes to GC through transcriptome analysis. We obtained sequencing data from UCSC Xena screened prognostic GEPIA2 database. The signature NETs was subsequently created using LASSO-Cox regression. clinical value model further explored nomogram externally validated GEO After that, we...
Hepatocellular carcinoma (HCC) is a fatal disease with great public health impact worldwide. Heme oxygenase (HO)-1 has recently been reported as an important player in tumor angiogenesis and metastasis. However, the role of HO-1 liver cancer metastasis unclear. In this study, we explored genetic differences downstream signal transduction pathways cell lines. wild-type mutant lines were generated from human line HepG2. The overexpression decreased migration HepG2 cells. contrast, HO-1G143H...
Host factors interacting with the dengue virus (DENV) 3' UTR are involved in replication, but their roles remain poorly understood. We used RNA affinity capture and mass spectrometry to identify p100 as a host cellular protein associated DENV UTR. By using immunoprecipitation confocal immunofluorescence analysis we demonstrated an interaction between DENV-infected cells. identified A4 region (the extensive stem-loop structure at end) binding site of by studying deletion mutants. knockdown...
The transcription factor GATA2 plays pivotal roles in early renal development, but its distribution and physiological functions adult kidney are largely unknown. We examined the expression pattern by tracing green fluorescent protein (GFP) fluorescence Gata2(GFP/+) mice that recapitulate endogenous found a robust GFP specifically medulla. Upon purification of GFP-positive cells, we collecting duct (CD)-specific markers, including aquaporin 2 (Aqp2), an important channel for water...
Chronic inflammation underlies the pathological progression of various diseases, and thus many efforts have been made to quantitatively evaluate inflammatory status diseases. In this study, we generated a highly sensitive inflammation-monitoring mouse system using bacterial artificial chromosome (BAC) clone containing extended flanking sequences human interleukin 6 gene (hIL6) locus, in which luciferase (Luc) reporter is integrated (hIL6-BAC-Luc). We successfully monitored...
A metropolitan official tourism website is an important medium to promote and communicate the metropolitan's tourist image due its marketing role reliability of information. This paper based on theories cultural capital destination image. Through content analysis New York Tokyo's websites in Chinese, this suggests innovative conceptual framework relation image, recognizing various types building Compared with natural resources, quantity has overwhelming advantage both websites; static...
Human globin gene production transcriptionally “switches” from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription cis elements scattered throughout the locus. The DRED (direct repeat erythroid-definitive) repressor recruited ε-globin γ-globin promoters orphan nuclear receptors TR2 (NR2C1) TR4 (NR2C2) engender their silencing in erythroid cells. Here we found receptor corepressor-1 (NCoR1) a critical component of...
Human γ-globin is predominantly expressed in fetal liver erythroid cells during gestation from 2 nearly identical genes, HBG1 and HBG2, that are both perinatally silenced. Reactivation of these genes adult red blood can ameliorate many symptoms associated with the inherited β-globinopathies, sickle cell disease, Cooley anemia. Although promising genetic strategies to reactivate treat diseases have been explored, there significant barriers their effective implementation worldwide;...
Acute kidney injury (AKI) is a leading cause of chronic disease. Proximal tubules are considered to be the primary origin pathogenic inflammatory cytokines in AKI. However, it remains unclear whether other cell types, including collecting duct (CD) cells, participate processes. The transcription factor GATA2 specifically expressed CD cells and maintains their cellular identity. To explore pathophysiological function AKI, we generated renal tubular cell-specific Gata2 deletion (G2CKO) mice...
Abstract Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation thermogenesis. The chromatin-remodeling machinery governs genome accessibility renders adipocytes poised for thermogenic activation remains elusive. Here we show BAF60a, subunit of the SWI/SNF complexes, serves an indispensable role in cold-induced thermogenesis brown fat. BAF60a maintains chromatin at PPARγ EBF2 binding sites key genes. Surprisingly, fat-specific inactivation...