A5044688218- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Heat shock proteins research
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Renal cell carcinoma treatment
- Endoplasmic Reticulum Stress and Disease
- Renal and related cancers
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Liver physiology and pathology
- Chronic Lymphocytic Leukemia Research
Shanghai University of Traditional Chinese Medicine
2024-2025
Carnegie Mellon University
2024-2025
Wayne State University
1993-2024
Eugene Applebaum College of Pharmacy and Health Sciences
2017-2024
Chinese Academy of Sciences
1999-2024
Institute of Hematology & Blood Diseases Hospital
2023-2024
Shanghai Jiao Tong University
2003-2024
Fudan University
2023-2024
Sichuan University
2016-2024
Fifth Affiliated Hospital of Zhengzhou University
2023-2024
The primary mission of Universal Protein Resource (UniProt) is to support biological research by maintaining a stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references querying interfaces freely accessible the scientific community. UniProt produced Consortium which consists groups from European Bioinformatics Institute (EBI), Swiss (SIB) Information (PIR). comprised four major components, each optimized for...
Nisin is a small gene-encoded antimicrobial protein produced by Lactococcus lactis that contains unusual dehydroalanine and dehydrobutyrine residues. The reactivity of these residues toward nucleophiles was explored reacting nisin with variety mercaptans. kinetics reaction 2-mercaptoethane-sulfonate thioglycolate indicated the pathway includes binding step. Reaction at high pH resulted in formation multimeric products, apparently as result intramolecular intermolecular reactions between...
Epidemiological studies have shown Per- and polyfluoroalkyl substances (PFAS) to be associated with diseases of dysregulated lipid sterol homeostasis such as steatosis cardiometabolic disorders. However, the majority mechanistic rely on single chemical exposures instead identifying mechanisms related toxicity PFAS mixtures. The goal current study is investigate linking exposure a mixture alterations in metabolism, including increased circulating cholesterol bile acids. Male female wild-type...
Purpose To assess the pharmacogenomic and pharmacokinetic determinants of skin rash diarrhea, two primary dose-limiting toxicities epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib. Patients Methods A prospective clinical study 80 patients with non–small-cell lung cancer, head neck ovarian cancer was performed. Detailed pharmacokinetics toxicity erlotinib were assessed. Polymorphic loci in EGFR, ABCG2, CYP3A4, CYP3A5 genotyped, their effects on evaluated. Results...
The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions complex traits. We identified determinants human liver gene variation using two independent collections primary tissue profiled with Agilent (n = 206) and Illumina 60) arrays SNP genotyping (550K), we also incorporated data from a published study 266). found that ∼30% SNP-expression correlations in one failed replicate either the others, even at thresholds yielding high reproducibility...
The epidermal growth factor receptor (EGFR) plays a prominent role in cell and development. Its regulation humans is complex incompletely understood. In this study, 12 new polymorphisms were discovered the 5'-regulatory region of EGFR gene 2 common single nucleotide (-216G/T -191C/A) found essential promoter area, one which located Sp1 recognition site (-216). Transient transfection human cancer primary lines showed significantly different activity between two most haplotypes (-216G-191C...
Childhood cancer survivors exposed to CNS irradiation are at increased risk for neurocognitive deficits; however, limited data exist linking outcomes with region-specific exposure irradiation. We report associations between radiation dose and self-reported health-related quality of life (HRQOL) in 818 adult childhood central nervous system (CNS) malignancies from the Cancer Survivor Study. Survivors were compared a sibling group national normative samples calculate standardized scores....
Long noncoding RNAs (lncRNA) have been observed in various cancer types. Our bioinformatic analysis of existing databases demonstrated overexpression lncRNA THAP9-AS1 pancreatic ductal adenocarcinoma (PDAC). We aimed to investigate the roles and mechanisms PDAC.The samples patients with was characterized associated clinical outcomes. The nonprotein coding property verified. Various vitro vivo experiments were performed interaction between YAP signaling.We that is overexpressed PDAC multiple...
Background and Aims: Increased megamitochondria formation impaired mitophagy in hepatocytes have been linked to the pathogenesis of alcohol‐associated liver disease (ALD). This study aims determine mechanisms by which alcohol consumption increases ALD. Approach Results: Human alcoholic hepatitis (AH) samples were used for electron microscopy, histology, biochemical analysis. Liver‐specific dynamin‐related protein 1 (DRP1; gene name DNM1L, an essential regulating mitochondria fission )...
Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER) transmembrane that regulates the formation of autophagosomes and lipid droplets. Recent evidence suggests VMP1 plays a critical role in lipoprotein secretion zebra fish cultured cells. However, pathophysiological roles mechanisms by which accumulation non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH) are unknown.Liver-specific hepatocyte-specific Vmp1 knockout mice as well knock-in were generated crossing...
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need identify new targetable pathways. Dysregulated glycine metabolism has emerged as causative factor therapeutic target NASH. Here, we report that tripeptide DT-109 (Gly-Gly-Leu) dose-dependently attenuates fibrosis mice. To enhance probability...
Pathogenesis roles of phospholipids (PLs) in nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This study investigated the role PLs progression NAFLD among obese individuals via studying alterations serum PL composition throughout spectrum and evaluating effects specific phosphatidylethanolamines (PEs) on FLD development vitro. A total 203 subjects, who were undergoing bariatric surgery, included this study. They histologically classified into 80 controls (C) with...
Male fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have classified as EDCs linked to adverse male reproductive health. The mechanisms these associations their implications on offspring health remain unknown. aims the current study were assess effect PFAS mixtures sperm methylome transcriptional changes metabolic tissues (i.e., liver fat). C57BL/6 mice exposed a mixture...
Fatty acid desaturase (FADS) genes and their variants have been associated with multiple metabolic phenotypes, including liver enzymes hepatic fat accumulation, but the detailed mechanism remains unclear. We aimed to delineate role of FADSs in modulating lipid composition human liver. performed a targeted lipidomic analysis variety phospholipids, sphingolipids, ceramides among 154 tissue samples. The associations between previously genome-wide association studies (GWASs)-identified six FADS...
Impairments in carbohydrate, lipid, and amino acid metabolism drive features of plaque instability. However, where these impairments occur within the atheroma remains largely unknown. Therefore, we sought to characterize spatial distribution metabolites stable unstable atherosclerosis both fibrous cap necrotic core.
Objectives Nine different functional UGT1A enzymes are generated from a single gene by alternative splicing, with each enzyme having unique exon 1. SN-38, the active metabolite of anticancer agent irinotecan, is metabolized both UGT1A1 and UGT1A9. We aim to characterize UGT1A9–UGT1A1 haplotypes in Asians Caucasians gain insights on their consequences. Methods Asian Caucasian individuals were genotyped for UGT1A9 variants. Results A higher frequency −118T10 allele was observed compared...
Subtilin and nisin are gene-encoded antibiotic peptides that ribosomally synthesized by Bacillus subtilis Lactococcus lactis, respectively. Gene-encoded antibiotics unique in their structures can be manipulated mutagenesis of structural genes. Although subtilin share considerable homology, has a greater tendency than to undergo spontaneous inactivation. This inactivation is accompanied chemical modification the dehydroalanine at position 5 (DHA5) with kinetic first-order t1/2 0.8 days. It...
Objective UDP-glucuronosyltransferase 2B7 (UGT2B7) plays a central role in the liver-mediated biotransformation of endogenous and exogenous compounds. The genetic basis interindividual variability UGT2B7 function is unknown. This study aimed to discover novel gene variants functional significance. Methods Caucasian human livers (n=54) were used. was resequenced 12 samples [(six highest six lowest for formation morphine-3-glucuronide (M3G)]. Haplotype-tagging single nucleotide polymorphisms...
The aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expression catalytic activity human hepatic UDP-glucuronosyltransferases (UGTs). Transcription levels five major UGT1A (UGT1A1, UGT1A3, UGT1A4, UGT1A6 UGT1A9) UGT2B (UGT2B4, UGT2B7, UGT2B10, UGT2B15 UGT2B17) genes were quantified in liver tissue samples (n = 125) using real-time PCR. Glucuronidation activities 14 substrates measured 47 livers. We genotyped 167 tagSNPs (single-nucleotide...