A5101992123- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Retinal Development and Disorders
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Neurogenesis and neuroplasticity mechanisms
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Retinoids in leukemia and cellular processes
- Head and Neck Cancer Studies
- Natural Antidiabetic Agents Studies
- Pluripotent Stem Cells Research
- Retinopathy of Prematurity Studies
- Esophageal Cancer Research and Treatment
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Neuroscience and Neural Engineering
- Alzheimer's disease research and treatments
University of Kansas Medical Center
2021-2022
University of Kansas
2018-2020
University of Rochester
2019
University of California, San Diego
2019
Background and Aims: Increased megamitochondria formation impaired mitophagy in hepatocytes have been linked to the pathogenesis of alcohol‐associated liver disease (ALD). This study aims determine mechanisms by which alcohol consumption increases ALD. Approach Results: Human alcoholic hepatitis (AH) samples were used for electron microscopy, histology, biochemical analysis. Liver‐specific dynamin‐related protein 1 (DRP1; gene name DNM1L, an essential regulating mitochondria fission )...
Background:Advanced glycation end products (AGEs) are an important risk factor for the development of cognitive decline in aging and late-onset neurodegenerative diseases including Alzheimer's disease. However, whether how dietary AGEs exacerbate impairment brain mitochondrial dys function process remains largely unknown. Objective:We investigated direct effects on AGE adducts accumulation, function, performance mice. Methods:Mice were fed AGE+ diet or AGE– diet. We examined levels serum...
Astrocytes, the most populous glial cell type in brain, are critical for regulating brain microenvironment. In various neurodegenerative diseases, astrocytes determine progression and outcome of neuropathological process. We have recently revealed direct involvement mitochondrial function human pluripotent stem (hiPSC)-derived dopaminergic (DA) neuronal differentiation. Using astroglial-neuronal co-culture system, we show here that effectively rescue defects neurogenesis DA neurons with...
Highlights•Type 6 bipolar cell dendrites remodel following cone death in mature retina•Bipolar input synapses are dependent, while output invariant•Cone loss leads to narrower excitation and wider inhibition of AON-S ganglion cells•Spatial receptive field changes not recapitulated by partial stimulationSummaryResilience neural circuits has been observed the persistence function despite neuronal loss. In vision, acuity sensitivity can be retained after 50% cones. While neurons cortex loss,...
Alcohol-related liver disease (ALD) and non-alcoholic fatty (NAFLD) are the primary causes of chronic in western countries.Liver transplantation is currently one most efficient approaches to save patients with failure, which often associated hepatic ischemia-reperfusion (IR) injury.IR injury exacerbated by steatosis, yet mechanism remains elusive.Necroptosis a form regulated cell death mediated receptor-interacting protein kinase 1 (RIP1), RIP3 mixed lineage domain-like (MLKL) protein, has...
Background: Transmembrane protein 41B (TMEM41B) and vacuolar membrane 1 (VMP1) are endoplasmic reticulum (ER) transmembrane scramblase proteins that have been recently identified to important roles in autophagy hepatic lipoprotein secretion. While TMEM41B VMP1 structurally functionally similar, the nature of their interactions how they coordinately regulate secretion metabolic-associated steatotic liver disease (MASLD) steatohepatitis (MASH) remains unclear. Methods: Liver-specific...
Equilibration of phospholipids between the two monolayers lipid bilayer cellular membranes is mediated by scramblases acting as phospholipid shuttling proteins that are critical for function, particularly during inter-organelle contact. Recent work has identified several protein scramblases, including TMEM41B, VMP1 and ATG9 in autophagy. More recently, ATG9, have also been discovered to be important regulators homeostasis. In vivo mouse models involving ablation TMEM41B liver shown knockout...
VMP1 is an ER membrane protein with phospholipid scramblase activity that has a critical role in regulating phagophore expansion and autophagosome closure. also regulates lipid droplet formation lipoprotein secretion cultured cells zebrafish. In recent study, we showed mice hepatic deletion of Vmp1 have impaired very-low-density (VLDL) develop nonalcoholic steatohepatitis (NASH) even when fed regular chow diet. Mechanistically, leads to decreased phosphatidylcholine (PC)...
Mitochondrial dysfunction and axonal degeneration are early pathological features of Alzheimer's disease (AD)-affected brains. The underlying mechanisms strategies to rescue mitochondrial synaptic injury remain largely unknown. Using human trans-mitochondrial cybrid (cytoplasmic hybrid) neuronal cells whose mitochondria were transferred from platelets patients with sporadic AD or age-matched non-AD subjects relatively normal cognition as well transgenic mice protein-induced stress, we...