Samer Gawrieh
A5019562801- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Gastroesophageal reflux and treatments
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- RNA modifications and cancer
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2016-2025
Indiana University
2023-2024
Indiana University Health
2024
University School
2023
Heinrich Heine University Düsseldorf
2023
Liver Institute Northwest
2023
Washington State University
2023
University Gastroenterology
2021
Indianapolis Zoo
2018
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236...
NAFLD is characterized by insulin resistance and dysregulated lipid glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor-α/γ agonist, improves sensitivity, glycemic parameters. Saroglitazar improved NASH histology in animal studies. In this randomized controlled clinical trial, we evaluated the efficacy safety of saroglitazar patients with NAFLD/NASH.A total 106 NAFLD/NASH alanine aminotransferase (ALT) ≥ 50 U/L at baseline body mass index ≥25 kg/m2 were...
The effects of diet quality (DQ), physical activity (PA), and socioeconomic status (SES) on the risk NAFLD are unclear. We examined association among DQ, PA, SES, risk.
Vitamin E improves liver histology in adults with nonalcoholic steatohepatitis (NASH) but not diabetes, its impact on long-term patient outcomes is unknown. We evaluated whether vitamin treatment clinical of NASH patients bridging fibrosis or cirrhosis. Two hundred and thirty-six biopsy-proven cirrhosis seen at Indiana University Medical Center between October 2004 January 2016 were included. Ninety them took 800 international units/day for ≥2 years (vitamin users) propensity-matched to 90...
Summary Background Limited data exist on the burden and features of non‐cirrhotic hepatocellular carcinoma (HCC) in United States. Aim To evaluate characteristics, aetiologies, trends outcomes HCC from 2000 to 2014 at five large US centres Methods Patient, tumour liver disease aetiology were collected. The presence underlying cirrhosis was assessed based published criteria. Results Of 5144 eligible patients with HCC, 11.7% had no cirrhosis. Non‐cirrhotic older (64.1 vs 61.2 years), more...
OBJECTIVES: Patients with nonalcoholic fatty liver disease (NAFLD) and normal aminotransferase levels may have advanced histology. We conducted a study to characterize the prevalence of factors associated histology in patients histologically characterized NAFLD levels. METHODS: evaluated 534 adults biopsy-proven alanine (ALT) aspartate (AST) <40U/L within 3 months their biopsy. Histological phenotypes primary interest were steatohepatitis (NASH) stage 2–3 fibrosis (NASH F2-3) cirrhosis....
Background and Aim: Data retrospective cohort studies have shown that liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) can predict mortality in patients with NAFLD, however, its ability to at a population level is unknown. We investigated the of LSM controlled-attenuation parameter (CAP) TE prospective US cohort. Approach Results: A total 4192 adults aged ≥18 years enrolled National Health, Nutrition Examination Survey (NHANES) (2017–2018) reliable information on...
Pathogenesis roles of phospholipids (PLs) in nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This study investigated the role PLs progression NAFLD among obese individuals via studying alterations serum PL composition throughout spectrum and evaluating effects specific phosphatidylethanolamines (PEs) on FLD development vitro. A total 203 subjects, who were undergoing bariatric surgery, included this study. They histologically classified into 80 controls (C) with...
Summary Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD. Aims To assess the effects of this new nomenclature on prevalence and distribution different SLD categories in people with HIV (PWH) identified factors associated MASLD clinically significant fibrosis (CSF). Methods PWH were prospectively enrolled from 9 US centres underwent clinical evaluation vibration‐controlled transient elastography controlled...
Background: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS alcohol-associated cirrhosis by comparing single-nucleotide polymorphisms among patients with (ALC) versus drinkers who did not have evidence liver fibrosis/cirrhosis. Methods: Using data-driven approach, ALC was generated using meta-genome-wide study (N=4305) an independent cohort heavy without...
The biological basis of variability in histological progression nonalcoholic fatty liver disease (NAFLD) is unknown. Dehydroepiandrosterone (DHEA) the most abundant steroid hormone and has been shown to influence sensitivity oxidative stress, insulin sensitivity, expression peroxisome proliferator-activated receptor alpha procollagen messenger RNA. Our aim was determine whether more histologically advanced NAFLD associated with low circulating levels DHEA. Serum samples were obtained...
Deficiencies in vitamins A, D, and E have been linked to night blindness, bone health, post-liver transplant reperfusion injury. The aim of this study was determine the prevalence predictive factors fat-soluble vitamin deficiencies liver candidates. We reviewed medical records candidates at our center from January 2008 September 2011. etiology cirrhosis, Model for End-Stage Liver Disease score, Child-Pugh class, body mass index (BMI), E, 25-OH-D levels were recorded. Patients excluded...
Metformin may protect against hepatocellular carcinoma and mortality among patients with type 2 diabetes.To investigate whether long-term use of metformin improves survival reduces liver-related outcomes diabetes non-alcoholic steatohepatitis.A total 191 diabetic biopsy-proven steatohepatitis bridging fibrosis or compensated cirrhosis were retrospectively identified at Indiana University Medical Center between October 2004 January 2016. Of them, 110 users 81 never-users metformin. Primary...