A5016102803- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Bariatric Surgery and Outcomes
- Folate and B Vitamins Research
- Obesity and Health Practices
- Pregnancy and preeclampsia studies
- Cardiovascular Disease and Adiposity
- Nutrition and Health in Aging
- Hepatitis B Virus Studies
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Pregnancy and Medication Impact
- Cardiovascular Function and Risk Factors
- Fibroblast Growth Factor Research
University of Chicago
1998-2025
Sungkyunkwan University
2024
Karolinska University Hospital
2024
Kangbuk Samsung Hospital
2024
Northwestern University
2013-2022
University of Chicago Medical Center
2022
Ruane Medical
2020
University Medical Center
2016-2020
Cambridge University Hospitals NHS Foundation Trust
2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019
The principal limitations of the terms NAFLD and NASH are reliance on exclusionary confounder use potentially stigmatising language. This study set out to determine if content experts patient advocates were in favor a change nomenclature and/or definition. A modified Delphi process was led by three large pan-national liver associations. consensus defined priori as supermajority (67%) vote. An independent committee external made final recommendation acronym its diagnostic criteria. total 236...
PREAMBLE The study of NAFLD has intensified significantly, with more than 1400 publications since 2018, when the last American Association for Study Liver Diseases (AASLD) Guidance document was published.1 This new AASLD reflects many advances in field pertinent to any practitioner caring patients and emphasizes noninvasive risk stratification therapeutics. A separate guideline focused on management context diabetes been written jointly by Clinical Endocrinology AASLD.2 Given significant...
The methionine choline-deficient (MCD) diet results in liver injury similar to human nonalcoholic steatohepatitis (NASH). aims of this study were define mechanisms MCD-induced steatosis insulin-resistant db/db and insulin-sensitive db/m mice. MCD-fed mice developed more hepatic retained insulin resistance than Both subcutaneous gonadal fat reduced by MCD feeding: decreased 23% 90% Weight loss was attenuated the mice, being only 13% compared with 35% respectively. strains had upregulation...
Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis, nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. The majority NAFLD subjects do not have NASH carry significant risk for liver-related adverse outcomes (cirrhosis mortality). Globally, the prevalence approximately 25%. In Asia, gradient high to low rates noted from urban rural areas. Given NAFLD, clinical economic burden can be substantial. With increasing recognition as an important...
Despite the substantial gains in our understanding of NAFLD/NASH over past 2 decades, there has been some dissatisfaction with terminology "non-alcoholic" which overemphasizes "alcohol" and underemphasizes root cause this liver disease, namely, predisposing metabolic risk factors. As a potential remedy, name change from NAFLD to associated fatty disease (MAFLD) proposed. Although MAFLD reflects relevant factors for term is still suboptimal, leaving great deal ambiguity. Here, we caution that...
Nonalcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH), are rapidly becoming among the top causes of cirrhosis, hepatocellular carcinoma, indications for transplantation. Other than lifestyle modification through diet exercise, there currently no other approved treatments NASH/NAFLD. Although weight loss can be effective, it is difficult to achieve sustain. In contrast, bariatric surgery improve metabolic conditions associated with NAFLD, has...
Lazarus, Jeffrey V.; Newsome, Philip N.; Francque, Sven M.; Kanwal, Fasiha; Terrault, Norah A.; Rinella, Mary E. Author Information
Nonalcoholic fatty liver disease (NAFLD) and heart failure (HF) are obesity-related conditions with high cardiovascular mortality. Whether NAFLD is independently associated subclinical myocardial remodeling or dysfunction among the general population unknown. We performed a cross-sectional analysis of 2,713 participants from multicenter, community-based Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent concurrent computed tomography (CT) quantification fat...