Elmar Aigner
A5000713998- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Folate and B Vitamins Research
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
Paracelsus Medical University
2016-2025
Universitätskliniken Salzburg
2017-2025
Salzburger Landeskliniken
2010-2025
University of Salzburg
2012-2024
Leuphana University of Lüneburg
2024
Unfallkrankenhaus Salzburg
2018-2023
Swiss Federal Institute of Aquatic Science and Technology
2023
Gesundheit Österreich
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Ospedale Maggiore
2022
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5-8% of lean subjects also have evidence NAFLD. We aimed investigate clinical, genetic, metabolic and lifestyle characteristics in Caucasian with NAFLD.Data from 187 allocated one the three groups according body mass index (BMI) hepatic steatosis on ultrasound were obtained: healthy (BMI≤25 kg/m2, no steatosis, N=71), NAFLD N=55), obese (BMI≥30 steatosis; N=61). All received a detailed clinical laboratory...
Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress well-established cause organ damage in liver, main site storage. Ferroptosis, an iron-dependent mechanism regulated cell death, has recently been gaining attention development and progression liver disease. We therefore summarize mechanisms metabolism, its close connection to ferroptosis, particular relevance disease metabolic-dysfunction-associated fatty...
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation. While RA primarily affects the joints, its effects may lead to an increased cerebro- and cardiovascular risk. Atherosclerosis of carotid arteries significant risk factor for cerebrovascular events serves as surrogate marker This study explores link between artery atherosclerosis with data from Paracelsus 10,000 Study. Baseline assessments were conducted on individuals randomly selected Salzburg...
Copper has a role in antioxidant defense, lipid peroxidation, and mitochondrial function, copper deficiency been linked to atherogenic dyslipidemia. We aimed investigate the potential of availability pathogenesis nonalcoholic fatty liver disease (NAFLD).Patients with NAFLD (n=124) were compared patients chronic hepatitis C (n=50), hemochromatosis (n=35), alcoholic (n=13), autoimmune (n=11), control subjects (n=27). determined serum concentrations correlation clinical, histological,...
Wilson disease (WD) is an inherited disorder of hepatic copper metabolism with considerable variation in clinical presentations, the most common ones being liver and neuropsychiatric disturbances. This study investigated presentation relation to mutations a large cohort patients WD. A total 1,357 (702 children, 655 adults; 1,172 index patients, 185 siblings, all Leipzig score ≥4, male/female: 679/678) were studied. The age symptoms at used as key phenotypic markers. Index clinically...
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of insulin resistance (IR), and IR associated with an increased risk colorectal carcinoma (CRC). Increased echogenicity suggesting NAFLD a frequent incidental finding on ultrasound examination. We aimed to systematically evaluate whether independent factor for colonic neoplasia.One thousand two hundred eleven patients (603 males, 60.6 ± 9.6 years; 608 females, 61.1 10.3 years) who underwent screening colonoscopy according...
Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing cirrhosis, whereas relevance of heterozygous carriage remains unclear. Hence, we evaluated impact two most relevant AAT variants (‘Pi*Z’ and ‘Pi*S’), present in up to 10% Caucasians, on subjects with non-alcoholic fatty liver disease (NAFLD) or alcohol misuse. Design We analysed multicentric case–control cohorts consisting 1184 people biopsy-proven NAFLD 2462 chronic misuse, both comprising cases...
A small proportion of lean patients develop non-alcoholic fatty liver disease (NAFLD). We aimed to report the histological picture NAFLD in comparison overweight and obese patients. Biopsy clinical data from 466 diagnosed with were stratified groups according body mass index (BMI): (BMI ≤ 25.0 kg/m², n confirmed be appropriate = 74), > 30.0 242) 150). Lean had a higher rate lobular inflammation compared (12/74; 16.2% vs. 19/242; 7.9%; p 0.011) but similar (25/150; 16.7%). Ballooning was...
The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty disease (NAFLD), alcohol-related disease, hepatitis B and C. We aim to understand mechanism by which contributes pathogenesis of NAFLD.