A5080536216- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal vascular conditions and treatments
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- Peptidase Inhibition and Analysis
Hospital de São João
2016-2025
Petrobras (Brazil)
2025
Universidade do Porto
2015-2024
Universidade Lusófona do Porto
2017-2018
Objective Alpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn disorder caused by mutations in alpha-1 (AAT). Homozygosity for the ‘Pi*Z’ variant of AAT (Pi*ZZ genotype) causes lung and liver disease, whereas heterozygous carriage (Pi*MZ predisposes to gallstones fibrosis. The clinical significance more common ‘Pi*S’ remains largely undefined no robust data exist on prevalence tumours AATD. Design Baseline phenotypes AATD individuals non-carriers were analysed 482 380...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the least deadly but most infectious strain transmitted from wild animals. It may affect many organ systems. Aim of current guideline to delineate effects SARS-CoV-2 on liver. Asymptomatic aminotransferase elevations are common in disease 2019 (COVID-19) disease. Its pathogenesis be multifactorial. involve primary liver injury and indirect such as "bystander hepatitis," myositis, toxic injury, hypoxia, preexisting Higher...
<b><i>Objectives:</i></b> Peroral cholangioscopy (POC) has shown to be a useful diagnostic procedure in the evaluation of biliary strictures; however, data regarding its role on preoperative staging are scarce. The aim this study was evaluate POC diagnosis and intraductal perihilar cholangiocarcinoma (CCA). <b><i>Methods:</i></b> Retrospective that included all patients who underwent with...
Abstract For over a decade, Petrobras has harnessed the power of ensemble-based methods, which represent state-of-the-art in data assimilation, to facilitate efficient history matching multiple reservoir models. Now, takes significant leap forward with launch "BR-Loop," an integrated and automated workflow designed transform collaboration between geosciences engineering disciplines modeling, characterization assimilation. BR-Loop connects all critical steps—from seismic depth conversion...
Benign esophageal strictures need repeated dilatations to relieve dysphagia. Literature is scarce on the risk factors for refractoriness of these strictures.This study aimed assess associated with refractory a retrospective patients benign who were referred dilatation over period 3 years.A total 327 performed in 103 patients; 53% reported dysphagia liquids. Clinical success was achieved 77% patients. There further 54% patients, being more frequent liquids [78 vs. 64%, P=0.008, odds ratio...
Inflammatory bowel disease (IBD) may be associated with a wide range of hepatobiliary manifestations. This study aimed to characterize the spectrum disorders in patients IBD who underwent liver biopsy for sustained abnormal function tests (LFT).A retrospective was performed all between January 2010 and December 2020 LFT (at least 6-month duration).A total 101 were included, mostly male (62.4%), mean age 44.4±13.3 years. The most common type Crohn's (61.4%). Median time interval 14 (7-36)...
<b><i>Introduction:</i></b> Controlled attenuation parameter (CAP), measured by transient elastography, has been suggested as a noninvasive method for the detection and quantification of steatosis. We aimed to assess accuracy CAP detect steatosis in patients with chronic liver disease (CLD) compared histology evaluate factors that correlate value. <b><i>Methods:</i></b> Patients CLD who underwent biopsy simultaneous determination were...
Background Ischaemic colitis (IC) is the most common form of intestinal ischaemia with a wide spectrum severity, possible risk death. Objective The purpose this study was to evaluate predictive factors in‐hospital and short‐term mortality, in cohort patients IC. Methods Retrospective analysis IC cases diagnosed between 2008–2013 single tertiary centre, assessment at time diagnosis associated 90‐day mortality. Results Of 203 included (132 women), 47 (23%) died during follow‐up (median: 16...
Patency capsule (PC) examination is usually performed - previously to endoscopy evaluate small-bowel patency in patients with established Crohn's disease (CD). The reported PC retention rate significantly higher than expected. Our aims were assess patency, determine the precise location of retained CD, and false positive evaluation a radiofrequency identification tag (RFIT) scanner.This prospective single-center study including CD clinical indication for endoscopy. PillCam® was on all...
Anal squamous intraepithelial lesions (ASIL) are precancerous of anal cell carcinoma, with a higher prevalence in immunosuppressed patients. There some studies kidney transplant recipients, but there is no information regarding liver transplantation. Our aim was to evaluate the ASIL this setting.Prospective case-control study involving recipients without any other known risk factor for (n=59), which were compared healthy control group (n=57). All submitted cytology and high-resolution...
<b><i>Introduction:</i></b> Endoscopic retrograde cholangiopancreatography (ERCP) is a technically demanding procedure with high risk for adverse events (AEs). <b><i>Aim:</i></b> evaluate patient- and procedure-related factors ERCP-related AEs develop an online app to estimate of AEs. <b><i>Methods:</i></b> retrospective study 1,491 consecutive patients who underwent 1,991 ERCPs between 2012 2017 was conducted....
Cirrhosis is one of the major causes morbidity and mortality worldwide. Portal hypertension contributor cirrhosis-related complications defined as a hepatic venous pressure gradient (HVPG) > 5 mmHg. Measurement HVPG an invasive, difficult, costly procedure. Therefore, it only performed in specialized centers. Liver stiffness measured with transient elastography most studied noninvasive markers portal hypertension, spleen has recently emerged important adjuvant tool. The development new probe...
Hepatic granulomas have an estimated prevalence of 5% in liver biopsies, with a wide range aetiologies globally. Our aim was to assess the clinical relevance, presenting features and underlying aetiology non-transplant, tertiary referral centre from western country.This retrospective, single-centre review clinical, laboratory histological data including all adult patients for whom biopsy performed January 1998 December 2014. A total 297 cases hepatic were found 9374 but 57 excluded analysis...