A5051139428- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet, Metabolism, and Disease
- Gastric Cancer Management and Outcomes
- Frailty in Older Adults
- Colorectal Cancer Screening and Detection
- Organ Donation and Transplantation
- Healthcare Policy and Management
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Food Security and Health in Diverse Populations
- HIV/AIDS drug development and treatment
- Nutritional Studies and Diet
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Hip and Femur Fractures
- Cannabis and Cannabinoid Research
University of Southern California
2020-2025
Touro University California
2025
Drexel University
2025
Keck Hospital of USC
2024
University of California, San Francisco
2014-2023
University of Washington
2012-2020
Université de Montréal
2019
Great Western Hospital
2017
University of Colorado Anschutz Medical Campus
2015
University of Modena and Reggio Emilia
2013
We report on the long-term intention-to-treat (ITT) outcome of 118 patients with hepatocellular carcinoma (HCC) undergoing downstaging to within Milan/United Network for Organ Sharing T2 criteria before liver transplantation (LT) since 2002 and compare results 488 listed LT HCC meeting at listing in same period. The subgroups include 1 lesion >5 ≤8 cm (n = 43), 2 or 3 lesions least one >3 ≤5 total tumor diameter 61), 4-5 each ≤3 14). In group, 64 (54.2%) had received 5 (7.5%) developed...
Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified the Model for End‐Stage Liver Disease (MELD) Sodium (MELDNa) score. We aimed to develop a frailty index capture these extrahepatic complications of cirrhosis enhance prediction in patients with cirrhosis. Consecutive outpatients listed liver transplantation at single transplant center without MELD exceptions were assessed candidate measures. Best subset...
Several factors are associated with increased hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT), but no reliable risk score has been established to determine the individual for HCC recurrence.We aimed develop and validate a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) patients meeting Milan criteria by imaging.Predictors were tested in development cohort 721 who underwent LT between 2002 2012 at 3 academic transplant centers (University...
The efficiency of hepatitis C virus (HCV) transmission by sexual activity remains controversial. We conducted a cross-sectional study HCV-positive subjects and their partners to estimate the risk for HCV infection among monogamous heterosexual couples. A total 500 anti-HCV-positive, human immunodeficiency virus-negative index long-term were studied. Couples interviewed separately lifetime factors infection, within-couple practices, sharing personal grooming items. Blood samples tested...
Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. We aimed objectively measure decline in patients with cirrhosis awaiting liver transplantation its association waiting list mortality. Consecutive adults listed for laboratory Model End‐Stage Liver Disease (MELD) ≥12 at a single center underwent status assessments every outpatient visit using the Short Physical Performance Battery (0 = impaired 12 robust), consisting of gait, chair stands,...
<h3>Importance</h3> Alcohol-associated liver disease (ALD) has emerged as the most common indication for transplant in United States, but data on reasons this increase and long-term post-liver outcomes among recipients are sparse. <h3>Objective</h3> To characterize trends of ALD States between 2002 2016. <h3>Design, Setting, Participants</h3> This multicenter, prospective, national cohort study used from Network Organ Sharing database to evaluate all transplants performed January 1, 2002,...
Background and Aims: The multisociety consensus nomenclature has renamed NAFLD to steatotic liver disease (SLD) with various subclassifications. There is a paucity of data regarding how the new modifies our understanding prevalence patient phenotypes. Approach Results: Using National Health Nutrition Examination Survey from January 2017 March 2020, we included all participants aged 18 years or above complete vibration-controlled transient elastography measures. SLD its subclassifications...
What do people care about in an image? To drive computational visual recognition toward more human-centric outputs, we need a better understanding of how perceive and judge the importance content images. In this paper, explore number factors relate to human perception importance. Proposed fall into 3 broad types: 1) related composition, e.g. size, location, 2) semantics, category object or scene, 3) contextual likelihood attribute-object, object-scene pairs. We these using what describe as...
It has been shown that patients with hepatocellular carcinoma (HCC) meeting the United Network for Organ Sharing T2 (Milan) criteria have an advantage in comparison without HCC under current organ allocation system liver transplantation (LT). We hypothesized within group, there is a subgroup low risk of wait-list dropout should not receive same listing priority. This study evaluated 398 consecutive listed LT Model End-Stage Liver Disease exception from March 2005 to January 2011 at our...
Frailty is prevalent in liver transplant candidates, but little known of what happens to frailty after transplantation. We analyzed data for 214 adult recipients who had ≥1 assessment using the Liver Index (LFI) at 3- (n = 178), 6- 139), or 12- 107) months posttransplant (higher values=more frail). "Frail" and "robust" were defined as LFI ≥4.5 <3.2. Median pre-liver was 3.7, worse 3 (3.9; P .02), similar 6 (3.7; .07), improved 12 (3.4; < .001). The percentage robust pre- 3-, 6-, 12-months...
AIMTo investigate the impact of physical frailty on risk hospitalisation in cirrhotic patients liver transplant waitlist.
United Network for Organ Sharing (UNOS) recently implemented a national policy granting priority listing liver transplantation (LT) in patients who achieved down-staging of hepatocellular carcinoma (HCC) to Milan criteria. We aimed evaluate the experience on by comparing two groups with (1) tumor burden meeting UNOS (UNOS-DS) inclusion criteria and (2) "all-comers" (AC-DS) initial beyond UNOS-DS versus always within Milan.
In the United States, 1 in 10 infants and 20 older children die on liver transplant waiting list. Increasing split transplantation could increase organ availability for these children, without decreasing transplants adults.Using Network Organ Sharing Standard Transplant Analysis Research data, we identified livers transplanted 2010 to 2015 that potentially have been used transplant, based strict criteria. Livers not suitable pediatric patients or allocated high-risk recipients were excluded....
High alpha‐fetoprotein (AFP) > 1,000 ng/mL is associated with poor outcomes after liver transplantation (LT) for hepatocellular carcinoma (HCC). A new national policy has been implemented AFP requiring a decrease to < 500 before LT, but there paucity of data on the optimal threshold LT. We aimed evaluate effects reduction in from different thresholds LT survival and HCC recurrence using United Network Organ Sharing database. identified 407 patients who underwent transplant between...
Whether direct‐acting antivirals (DAAs) increase the risk of hepatocellular carcinoma (HCC) recurrence after tumor‐directed therapy is controversial. We sought to determine impact DAA on HCC local‐regional (LRT) and waitlist dropout among liver transplant (LT) candidates with HCC. performed a retrospective cohort study 149 LT hepatitis C virus (HCV) at single center from 2014 through 2016. Cumulative incidence post‐LRT was estimated by group. Factors associated each outcome were evaluated...
Researchers in a recent multicenter study developed and validated novel prognostic index, Risk Estimation of Tumor Recurrence After Transplant (RETREAT), which incorporates α-fetoprotein (AFP) at liver transplantation (LT), microvascular invasion, the sum largest viable tumor number tumors on explant. We now aim to evaluate RETREAT United Network for Organ Sharing (UNOS) database patients with hepatocellular carcinoma (HCC) who meet Milan criteria by imaging underwent LT between 2012 -2014....
Background and Aims Frailty, as measured by the Liver Frailty Index (LFI), is associated with liver transplant (LT) waitlist mortality. We sought to identify an optimal LFI cutoff that predicts Approach Results Adults cirrhosis awaiting LT without hepatocellular carcinoma at nine centers in United States assessments were included. Multivariable competing risk analysis assessed relationship between identified a single evaluating fit of models, searching for gave best model (as judged...
Naltrexone is an approved drug for management of alcohol use disorder (AUD), but data in patients with liver disease (LD) are limited. We aimed to evaluate the safety naltrexone those LD. This a retrospective cohort adults and without LD who were prescribed AUD from 2015 2019 safety-net setting. hepatic was determined by enzyme changes during after compared before prescription as well rates subsequent hospitalization death Kaplan-Meier methods. Factors associated examined Cox regression. Of...