A5059888713- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Clinical Nutrition and Gastroenterology
- Hepatocellular Carcinoma Treatment and Prognosis
- Hormonal and reproductive studies
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Drug-Induced Hepatotoxicity and Protection
- Renal Transplantation Outcomes and Treatments
- Muscle metabolism and nutrition
- Ovarian function and disorders
- Pharmacology and Obesity Treatment
- Liver Diseases and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alcohol Consumption and Health Effects
- Parathyroid Disorders and Treatments
- Frailty in Older Adults
- Polyomavirus and related diseases
- Healthcare and Venom Research
- Thermoregulation and physiological responses
Austin Health
2016-2025
The University of Melbourne
2016-2025
Austin Hospital
2013-2024
Australian Centre for International Agricultural Research
2024
Arizona Liver Health
2023
University of Chicago
2023
University of California, San Francisco
2017-2018
Baylor University Medical Center
2018
University of Michigan
2018
Baylor Scott & White Health
2015
Background and Aims: Aldafermin, an engineered analog of the human hormone FGF19, improves liver histology in patients with noncirrhotic NASH; however, its efficacy safety compensated cirrhosis is unknown. No drug has yet to demonstrate benefit NASH population. Approach Results: In this multicenter, double-blind, placebo-controlled, phase 2b trial, 160 were randomized aldafermin 0.3 mg (n = 7), 1 42), 3 55), or placebo 56) for 48 weeks. The group was discontinued limit exposure suboptimal...
AIMTo investigate the impact of physical frailty on risk hospitalisation in cirrhotic patients liver transplant waitlist.
Sarcopenia is associated with mortality in cirrhosis, but there no gold standard for its diagnosis. The comparative utility of different diagnostic methods unknown. This single-center observational cohort study followed 145 men referred liver transplant evaluation between 2005 and 2012. Muscle mass was estimated by handgrip strength, dual energy X-ray absorptiometry (DEXA) lean mass, single-slice computed tomography (CT) scan at the fourth lumbar vertebra. Recorded outcomes included time to...
Observational studies suggest a beneficial effect of continuous terlipressin infusion (CTI) on ascites and sarcopenia in decompensated cirrhosis with portal hypertension.
Current guidelines recommend long-term nucleot(s)ide analogue (NA) therapy for patients with HBeAg-negative chronic hepatitis B (CHB). However, disease remission has been described after stopping NA therapy, as well HBsAg loss.We performed a prospective multi-centre cohort study of therapy. Inclusion criteria were CHB, the absence cirrhosis and HBVDNA<lower limit quantification ≥18 months. We assessed virological biochemical outcomes including loss, restart rates, over 96 weeks.In total, 110...
Abstract Background and Aim Both sarcopenia low serum testosterone have been associated with increased mortality in men cirrhosis. It is not known how these variables interact. Methods We conducted a retrospective longitudinal cohort study of 145 referred for liver transplant evaluation between 2005 2012. Baseline demographics included hormone profile model end‐stage disease (MELD) score. computerized tomography was reformatted to calculate skeletal muscle area at L4 using validated,...
Sarcopenia is associated with adverse outcomes in cirrhosis. Branched-chain amino acids (BCAA) target several pathways that lead to muscle loss this population.
Endoscopic variceal band ligation (EVBL) aims to eradicate high-risk oesophageal varices. There is a small risk of precipitating bleeding from EVBL-induced ulceration, which associated with significant mortality. We explore the factors and outcome ulcer bleeding.Retrospective review our endoscopy database between 2007 2012 identified upper endoscopies during EVBL was performed. Patient demographics, biochemistry endoscopic findings were recorded as complications death.A total 749 episodes...
Reduced muscle area on CT scan is an independent predictor of mortality in cirrhosis. We examine for the first time relationship between dual energy x-ray absorptiometry (DEXA) lean mass parameters outcomes cirrhotic men awaiting liver transplantation.We retrospectively reviewed DEXA scans performed during transplant assessment 2001 and 2016. Baseline data including presence ascites MELD score were recorded. measures adjusted height. The primary outcome was 12-month wait-list mortality.Four...
Background and Aims: HBV RNA in peripheral blood reflects cccDNA transcriptional activity may predict clinical outcomes. The prospective Melbourne HBV-STOP trial studied nucleot(s)ide analog discontinuation HBeAg-negative non-cirrhotic participants with long-term virological suppression. Ninety-six weeks after stopping treatment, the proportion of relapse (HBV DNA > 2000 IU/mL), biochemical (ALT 2 × ULN or hepatitis flare 5 IU/mL) was 89%, 58%, 38%, respectively. We evaluated ability...
Accurate biomarkers to predict outcomes following discontinuation of nucleos(t)ide analogue (NA) therapy are needed. We evaluated serum hepatitis B core-related antigen (HBcrAg) level as a biomarker for predicting after NA discontinuation.
ABSTRACT Introduction Our goal is to understand whether there an association between Abx exposure—and the inferred downstream damage intestinal microbiome—and key patient outcomes of overall survival and rejection following liver transplant. Methods We conducted a retrospective cohort study 462 transplant recipients treated at multistate (LTx) service during 7‐year period. The antibiotic exposure outcome was tested across models that addressed spectrum, duration, timing relative Cox...
BACKGROUND Sarcopaenia is associated with a two-fold higher mortality rate in patients cirrhosis independent of liver disease severity. Few treatments for related sarcopaenia exist beyond optimal nutritional management. AIM To assess if rifaximin-α, minimally absorbed antimicrobial used to manage hepatic encephalopathy (HE), may improve through its ammonia lowering and anti-inflammatory properties. METHODS This single-centre retrospective cohort study prior HE compared treated lactulose...
Abstract Background In clinical trials, hepatitis C virus (HCV) salvage treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) achieved an SVR12 rate of &gt;95% in NS5A-experienced participants. Lower rates have been reported real-world studies, particularly for genotype (GT)3 infection and cirrhosis. We determined the efficacy safety SOF/VEL/VOX a large cohort. Methods assessed HCV NS5A-inhibitor experienced participants cirrhosis portal hypertension, prior liver...
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in people with diabetes no available treatment.To explore the effect of testosterone treatment on liver. Testosterone therapy improves insulin resistance and reduces total body fat, but its impact remains poorly studied.This secondary analysis a 40 wk, randomised, double-blinded, placebo-controlled trial intramuscular undecanoate men type 2 lowered serum concentrations evaluated change hepatic steatosis as measured by fat fraction...
BACKGROUND De novo malignancy is a leading cause of late morbidity and mortality in liver transplant recipients. Cumulative immunosuppression has been shown to contribute post-transplant (PTM) risk. There emerging evidence on the differential carcinogenic risk profile individual immunosuppressive drugs, independent net effect immunosuppression. Calcineurin inhibitors such as tacrolimus may promote tumourigenesis, whereas mycophenolic acid (MPA), active metabolite mycophenolate mofetil, limit...
Diabetes at time of liver transplantation is associated with reduced post-transplant survival. We aimed to assess whether additional metabolic conditions such as obesity or hypertension had additive prognostic impact on post-transplantation survival.A multi-center cohort study 617 adult subjects undergoing between 2003 and 2009 has been used. Dry body mass index was calculated following adjustment for ascites.After a median follow-up 5.8 years (range 0-10.5), 112 (18.2%) patients died....