A5009835306- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Immunodeficiency and Autoimmune Disorders
- Clostridium difficile and Clostridium perfringens research
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Peripheral Nerve Disorders
- Cancer therapeutics and mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Pharmaceutical Economics and Policy
- Potassium and Related Disorders
- Mobile Health and mHealth Applications
- Gastroesophageal reflux and treatments
- Alcoholism and Thiamine Deficiency
- Opioid Use Disorder Treatment
- bioluminescence and chemiluminescence research
Monash Health
2021-2025
Austin Hospital
2019-2024
Seagen (United States)
2024
Austin Health
2019-2023
Monash University
2023
The University of Melbourne
2019
University of Missouri Health System
2014
University of Missouri
2014
OSF Saint Francis Medical Center
2008
University of Pittsburgh
1992
Abstract Background Crohn’s disease (CD) and ulcerative colitis (UC) have been associated with the major histocompatibility complex in genome wide association studies (1) subsequently this area is most widely studied genetic region. HLA-DRB1*01:03 has susceptibility to both CD UC (2), severe (3). However, frequency of allele known vary by ethnicity. We aimed determine HLA DRB1*01:03 a multi-ethnic Australian population its refractory disease. Methods At single centre, tertiary Inflammatory...
Reduced muscle area on CT scan is an independent predictor of mortality in cirrhosis. We examine for the first time relationship between dual energy x-ray absorptiometry (DEXA) lean mass parameters outcomes cirrhotic men awaiting liver transplantation.We retrospectively reviewed DEXA scans performed during transplant assessment 2001 and 2016. Baseline data including presence ascites MELD score were recorded. measures adjusted height. The primary outcome was 12-month wait-list mortality.Four...
BACKGROUNDAcute liver failure (ALF) is a life-threatening syndrome with varying aetiologies requiring complex care and multidisciplinary management.Its changing incidence, aetiology outcomes over the last 16 years in Australian context remain uncertain. AIMTo describe of ALF South Eastern Australia.
Abstract Background Biologic drugs are highly effective for inflammatory bowel disease (IBD) management but key drivers of costs care especially when administered intravenously (i.v.). Availability subcutaneous (SC) formulations has increased convenience patients and improved access to care, at the cost revenue health services. Aims To evaluate economic impact transitioning a tertiary centre IBD cohort from i.v. SC biologic administration assess implications stakeholders. Methods A...
A prescription is a health-care program implemented by physician or other qualified practitioner in the form of instructions that govern plan care for an individual patient. Although algorithmic nature prescriptions axiomatic, this insight has not been applied systematically to medication safety. We used software design principles and debugging methods create “Patient-oriented Prescription Analgesia” (POPA), assessed rate extent adoption POPA physicians, conducted statistical process control...
Sensory potentials recorded from the dorsal cutaneous branch of ulnar nerve (DCUN) help localize lesions. This conduction technique was first described by Jabre in 1980. Abnormalities detected with this control populations are commonly attributed to local trauma. Anatomic variations innervation dorsum hand, however, have been described. We DCUN responses using both normal stimulation point and a secondary site at radial aspect forearm 44 patients. Eleven patients demonstrated low-amplitude...
Abstract Topoisomerase 1 (TOP1) inhibitors are a class of cytotoxic small molecules that have demonstrated effectiveness as therapeutic agents in cancer. However, the broad clinical application has been hindered by poor pharmacokinetic profiles and off-target toxicities. Antibody-drug conjugates (ADCs) enable targeted delivery payloads specifically targeting cell-surface antigens expressed on cancers reducing systemic exposure toxicity. TOP1-ADCs received FDA approval for HER2-...
Abstract Background The management of pain in patients with advanced liver disease is a clinical challenge. Initial pharmacokinetic safety data advised against the use oxycodone–naloxone this population, but practice it commonly used. Our case aims to illustrate potential mechanism by which administration can cause systemic opioid antagonism and harm patients. Clinical details A 45‐year‐old man received two separate doses immediate postoperative setting, resulting symptoms signs consistent...
Abstract Background Biologic drugs are highly effective for inflammatory bowel disease (IBD) management but key drivers of costs care especially when administered intravenously (IV). Availability subcutaneous (SC) formulations has increased convenience patients and improved access to at the cost revenue health services. The aim this study was evaluate economic impact transitioning a tertiary centre IBD cohort from IV SC biologic administration assess implications stakeholders. Methods A...
Abstract Background Vedolizumab is effective in inducing and maintaining remission patients with both Crohn’s Disease (CD) ulcerative colitis (UC). Recent data has demonstrated that there superior persistence vedolizumab compared to anti-TNF biologics. However, the efficacy of dose intensified remains uncertain. We aimed assess whether intensification resulted a meaningful improvement treatment determine were any clinical, biochemical or endoscopic parameters associated response...
To the Editors, We report case of a 33-year-old female who developed dual pathologies synchronous multifocal colonic dysplasia and post-transplant lymphoproliferative disease (PTLD). Her medical history was significant with an orthotopic liver transplant for autoimmune hepatitis 16 years earlier long-standing chronic active ulcerative colitis refractory to infliximab vedolizumab. A colonoscopy, undertaken due severe activity despite 300 mg vedolizumab administered every 4 weeks, demonstrated...