A5028263779- Hepatitis C virus research
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- Trace Elements in Health
- Immunodeficiency and Autoimmune Disorders
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
Western Sydney University
2017-2025
Westmead Institute for Medical Research
2016-2025
Sydney Local Health District
2019-2025
Blacktown & Mount Druitt Hospital
2018-2025
The University of Sydney
2015-2024
Westmead Hospital
2014-2023
Westmead Institute
2011-2022
Camden and Campbelltown Hospitals
2020-2021
RELX Group (Netherlands)
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2005-2014
Vijayaprakash Suppiah and colleagues show that genotyping hepatitis C patients for the IL28B, HLA-C, KIR genes improves ability to predict whether or not will respond antiviral treatment.
Abstract Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and likely be influenced by host genetic architecture. Here we demonstrate, using liver disease as model, single-nucleotide polymorphism ( rs12979860) intronic region interferon-λ4 (IFNL4) strong predictor an aetiology-independent manner. In cohort 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 B (CHB) 488 non-alcoholic fatty (NAFLD), those rs12979860CC have...
Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological observations have not been reported. Using an vitro model infection with influenza A virus (IAV), we attribute differences human NK activity distinct KIR/HLA genotypes. Multicolor flow cytometry revealed that HLA-C–inhibited subset HLA-C1 homozygous subjects was larger and responded more rapidly...
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort 24 participants, association disease severity early immune responses on humoral 12 months post-infection examined. All severely affected participants maintain a stable subset SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) good neutralizing antibody breadth...
HIV has evolved several strategies to evade recognition by the host immune system including down-regulation of major histocompatibility complex (MHC) class I molecules. However, reduced expression MHC molecules may stimulate natural killer (NK) cell lysis in cells haematopoietic lineage. Here, we describe how counteracts stimulation NK stabilizing surface non-classical molecule, HLA-E. We demonstrate enhanced HLA-E on lymphocytes from HIV-infected patients and show that vitro infection with...
Natural killer (NK) cells exhibit a polarized phenotype with increased cytotoxicity and decreased interferon gamma (IFN–γ) production in chronic hepatitis C virus (HCV) infection. Here, we asked whether this is caused by type I (IFN)–induced expression phosphorylation levels of signal transducer activator transcription (STAT) molecules NK it affects the response refractoriness to IFN–α–based therapy HCV. STAT1 were significantly higher patients HCV infection than uninfected controls....
Although hepatitis C virus (HCV) has been shown to readily escape from virus-specific T and B cell responses, its effects on natural killer (NK) cells are less clear. Based two previous reports that recombinant, truncated HCV E2 protein inhibits NK functions via crosslinking of CD81, it is now widely believed impairs as a means establish persistence. However, the relevance these findings not verified with expressed part intact virions. Here we employed new culture system generating...
Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation fibrosis in viral non-viral diseases. Here we demonstrate that macrophages primary responders IFN-λ, uniquely positioned bridge gap between producing cells lymphocyte populations intrinsically responsive IFN-λ. While CD14+ monocytes do express receptor, IFNLR1, sensitivity is quickly gained...
Background The global COVID-19 pandemic has impacted on the mental health of individuals, particularly those with chronic illnesses. We aimed to quantify stress, anxiety and depression among individuals Inflammatory bowel disease (IBD) in Australia during pandemic. Methods An electronic survey was made available IBD patients Australia-wide from 17 June 12 July 2020. Respondents an underlying diagnosis over 18 years age were included. A validated questionnaire (Depression, Anxiety, Stress...
The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard care therapy is currently pegylated interferon alpha and ribavirin (PegIFN/R), which effective less than half those infected with most common viral genotype. Two IL28B single nucleotide polymorphisms (SNPs), rs8099917 rs12979860, predict response to (PegIFN/R) treatment HCV infection. These SNPs were identified genome wide analyses using Illumina genotyping chips. In people...
<h3>Objective</h3> Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of and action ribavirin C. <h3>Design</h3> 70 treatment-naive patients were randomised 4 weeks (1000–1200 mg/d) or none, followed by PEG-IFNα-2a at standard doses durations. Patients also a liver biopsy 24 h before 6 after starting PEG-IFN. Hepatic gene expression was assessed microarray interferon-stimulated (ISG)...
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well inflammation fibrosis progression non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that CC genotype correlates with increased hepatic metallothionein expression through systemic zinc levels. Zinc interferes IFN-λ3...
Objective Vaccination against hepatitis B virus (HBV) confers protection from subsequent infection through immunological memory that is traditionally considered the domain of adaptive immune system. This view has been challenged following identification antigen-specific natural killer cells (mNKs) in mice and non-human primates. While presence mNKs suggested humans based on expansion NK pathogen exposure, evidence regarding antigen-specificity lacking. Here, we demonstrate existence...