A5038842219- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Epistemology, Ethics, and Metaphysics
- Philosophy and Theoretical Science
- Renal Transplantation Outcomes and Treatments
- Liver Diseases and Immunity
- Philosophy and History of Science
- Free Will and Agency
- Psychology of Moral and Emotional Judgment
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Philosophical Ethics and Theory
- Probability and Statistical Research
- Pancreatitis Pathology and Treatment
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Classical Philosophy and Thought
- Hepatitis Viruses Studies and Epidemiology
- Pancreatic function and diabetes
Cardiff University
2013-2025
Launceston General Hospital
2022-2025
Anzac Research Institute
2020-2024
UNSW Sydney
2015-2023
University of Oxford
2006-2022
Wellcome Centre for Ethics and Humanities
2010-2022
Ingham Institute
2017-2021
Liverpool Hospital
2017-2021
The University of Sydney
2010-2020
South Western Sydney Local Health District
2018-2020
Real‐time quantitative reverse transcriptase–polymerase chain reaction (RT–PCR) is the method of choice for rapid and reproducible measurements cytokine or growth factor expression in small samples. Fluorescence detection methods monitoring real‐time PCR include fluorogenic probes labelled with reporter quencher dyes, such as Taqman Molecular Beacons dsDNA‐binding dye SYBR Green I. Fluorogenic (Taqman) a range human rat cytokines factors were tested sensitivity compared an assay I...
Although religious belief is often claimed to help with physical ailments including pain, it unclear what psychological and neural mechanisms underlie the influence of on pain. By analogy other top-down processes pain modulation we hypothesized that helps believers reinterpret emotional significance leading detachment from it. Recent findings emotion regulation support a role for right ventrolateral prefrontal cortex (VLPFC), region also important driving inhibitory circuits. Using...
ABSTRACT Chronic infection by hepatitis B virus (HBV) is the major contributor to liver disease worldwide. Though HBV replicates via a nuclear episomal DNA (covalently closed circular [cccDNA]), integration of into host cell genome regularly observed in infected patients. While reported as prooncogenic alteration, mechanism(s) and timing are not well understood, chiefly due lack vitro models that have detectable events. In this study, we established an system which can be reliably detected...
Donor liver steatosis can impact on allograft outcomes. The aim of the present study was to comprehensively report type and grade donor steatosis, as well recipient factors, including reported Risk Index (DRI), outcomes.A review unit data for all adult transplant procedures from 2001 2007, offers. biopsies were regraded by an experienced histopathologist.Steatosis detected in 184/255 (72%) biopsies, which 114 (62%) had microvesicular (MiS; 68 mild, 22 moderate, 24 severe) 70 (38%)...
Neuroimaging studies on moral decision-making have thus far largely focused differences between judgments with opposing utilitarian (well-being maximizing) and deontological (duty-based) content. However, these investigated dilemmas involving extreme situations, did not control for two distinct dimensions of judgment: whether or it is intuitive (immediately compelling to most people) in By contrasting where are counterintuitive which they intuitive, we were able use functional magnetic...
<h3>BACKGROUND</h3> Primary biliary cirrhosis (PBC) is an autoimmune disease in which the pathogenesis of progressive liver injury poorly understood. <h3>AIM</h3> To provide novel insights into PBC related using cDNA array analysis, simultaneously examines expression many genes. <h3>METHODS</h3> Utilising arrays 874 genes, was compared with primary sclerosing cholangitis (PSC) associated and non-diseased liver. Differential 10 genes confirmed by real time quantitative reverse...
Neuroscience and psychology have recently turned their attention to the study of subpersonal underpinnings moral judgment. In this article we critically examine an influential strand research originating in Greene's neuroimaging studies 'utilitarian' 'non-utilitarian' judgement. We argue that given explananda are specific personal-level states—moral judgments with certain propositional contents—its methodology has be sensitive criteria for ascribing states such contents subjects. current...
Summary Hepatocyte clone size was measured in liver samples of 21 patients various stages chronic hepatitis B virus ( HBV ) infection and from to 76 years age. clones containing unique virus–cell DNA junctions formed by the integration were detected using inverse nested PCR . The maximum hepatocyte tended increase with age, although there considerable patient‐to‐patient variation each age group. There an upward trend increasing fibrosis, inflammatory activity seroconversion e‐antigen HB e A...
Obese Alms1 mutant (foz/foz) NOD.B10 mice develop diabetes and fibrotic NASH when fed high-fat(HF) diet. To establish whether or obesity is more closely associated with fibrosis, we compared diabetic foz/foz C57BL6/J non-diabetic BALB/c mice. We also determined hepatic cytokines, growth factors related profibrotic pathways.Male female were HF chow for 24 weeks before determining metabolic indices, liver injury, factors, pathology/fibrosis matrix deposition pathways.All obese. Hepatomegaly,...
Recent research on moral decision-making has suggested that many common judgments are based immediate intuitions. However, some individuals arrive at highly counterintuitive utilitarian conclusions about when it is permissible to harm other individuals. Such have been attributed effortful reasoning overcome our natural emotional aversion harming others. studies, however, suggest such might also result from a decreased others, due deficit in empathic concern and social emotion. The present...
The principle of indifference is supposed to suffice for the rational assignation probabilities possibilities. Bertrand advances a probability problem, now known as his paradox, which apply; yet, just because problem ill-posed in technical sense, applying it leads contradiction. Examining an ambiguity notion shows that there are precisely two strategies resolving paradox: distinction strategy and well-posing . main contenders Marinoff Jaynes, offer solutions exemplify these strategies. I...