A5083877666- Organ Transplantation Techniques and Outcomes
- Reproductive Biology and Fertility
- Liver Disease and Transplantation
- Ovarian function and disorders
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Advanced NMR Techniques and Applications
- Renal and related cancers
- Metabolomics and Mass Spectrometry Studies
- Total Knee Arthroplasty Outcomes
- Ureteral procedures and complications
- NMR spectroscopy and applications
- Biomedical Text Mining and Ontologies
- Bone and Joint Diseases
- Knee injuries and reconstruction techniques
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and Vascular Pathologies
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Gastrointestinal disorders and treatments
- Assisted Reproductive Technology and Twin Pregnancy
Max Planck Institute for Multidisciplinary Sciences
2023
Indian Institute of Science Bangalore
2020-2022
Methodist Hospital
2020
Royal Prince Alfred Hospital
2004-2018
Mahatma Gandhi University
2017
Concord Repatriation General Hospital
2013-2016
The University of Texas at Austin
1988-2013
The University of Sydney
2013
Sir Charles Gairdner Hospital
2012
Peter MacCallum Cancer Centre
2012
To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer.Eligible patients had ultrasound- or magnetic resonance imaging-staged T3N0-2M0 adenocarcinoma within 12 cm from anal verge. SC consisted of pelvic 5 × Gy in 1 week, early surgery, six courses adjuvant chemotherapy. LC was 50.4 Gy, 1.8 Gy/fraction, 5.5 weeks, with continuous infusional fluorouracil 225 mg/m(2) per day, surgery 4 to 6 four chemotherapy.Three...
We evaluated the results in eighty-three patients (ninety-five knees) who had a high tibial osteotomy for either unicompartmental osteoarthritis or osteonecrosis. The operations were performed between 1965 and 1976. mean length of follow-up was 8.9 years (range, five to fifteen years). early promising: at two 97 per cent 85 knees an excellent good result. At subsequent follow-up, however, only sixty (63 cent) result, remainder recurrent pain developed. Twenty-two (23 been revised total knee...
Abstract Small molecule immune checkpoint inhibitors targeting PD-1 and other pathways may offer advantages including ease of dosing, ability to manage immune-related adverse events (irAEs) due their shorter pharmacokinetic exposure opportunity target more than one pathway for improving efficacy. Here we describe the identification characterization CA-170, an amino acid inspired small inhibitor PD-L1 VISTA derived from interface PD-L1. CA-170 exhibited potent rescue proliferation effector...
Donor liver steatosis can impact on allograft outcomes. The aim of the present study was to comprehensively report type and grade donor steatosis, as well recipient factors, including reported Risk Index (DRI), outcomes.A review unit data for all adult transplant procedures from 2001 2007, offers. biopsies were regraded by an experienced histopathologist.Steatosis detected in 184/255 (72%) biopsies, which 114 (62%) had microvesicular (MiS; 68 mild, 22 moderate, 24 severe) 70 (38%)...
The anterior distal part of the iliotibial trace with attached bone block from Gerdy's tubercle was used as an intra-articular graft fixed by a screw to tibia control instability (otherwise known anterior, anteromedial, or anterolateral laxity) in twenty-four knees which were followed for two four years. Concomitant single-plane 2+ 4+ medial present eleven and treated five them simple immobilization, imbrication collateral ligament, Vigliani procedure. At follow-up, stability improved result...
Accurate preoperative staging of anorectal neoplasia is required to identify patients for whom local excision or adjuvant therapy may be appropriate. The objectives this study were review the accuracy endoluminal transrectal ultrasonography (TRUS) in rectal cancers and determine learning curve before optimal can achieved.The results all TRUS examinations assessment performed by two colorectal surgeons at teaching hospitals University Sydney from 1991 2001 collected prospectively.Of 433...
The objectives of this study were to define appropriate criteria for assessing the presence lymphedema, and report prevalence risk factors development upper limb lymphedema after level I-III axillary dissection melanoma.The lack a consistent reliable objective definition remains significant barrier appreciating its melanoma (or breast carcinoma).Lymphedema was assessed in 107 patients (82 male, 25 female) who had previously undergone complete dissection. Of patients, 17 also received...
Hepatic artery stenosis (HAS) is thought to predispose patients biliary complications secondary ischemic injury. Despite this, the clinical significance of HAS remains poorly defined. The aims this study were determine prevalence and outcomes define which might benefit from endovascular treatment. From a prospective database 662 adult undergoing liver transplantation between 2000 2011, we identified 54 who developed HAS. was defined as any > 70% that seen during multidetector computed...
Abdominal actinomycosis (AA) is a rare infection caused by filamentous Gram-positive anaerobic bacteria Actinomyces. We report two cases of adults with AA who initially presented clinical and radiological features appendicitis. Both patients underwent appendicectomy histopathology diagnostic for the appendix subsequently completed prolonged courses oral penicillin. differential diagnosis appendicitis should be considered especially in chronic, indolent course nonspecific abdominal symptoms....
Abstract This study investigated whether combining metabolomic and embryologic data with machine learning (ML) models improve the prediction of embryo implantation potential. In this prospective cohort study, infertile couples ( n =56) undergoing day-5 single blastocyst transfer between February 2019 August 2021 were included. After transfer, spent culture medium (SCM) was subjected to metabolite analysis using nuclear magnetic resonance (NMR) spectroscopy. Derived levels parameters...
We report the synthesis and structural characterization of a dicobalt(III) complex with μ-OH,μ-O2 core, namely μ-OH,μ-O2-[Co(enN4)]2(X)3 [1(ClO4)3 1(BF4)3]. The dinuclear core is cross-linked by two N4 Schiff base ligands that span each cobalt center. formally CoIII–CoIII dimer formed spontaneously upon exposure mononuclear Co(II) to air exhibits ν(O–O) value at 882 cm–1 shifts 833 substitution 18O2. CV 1(BF4)3 reversible {CoIII–CoIII}↔{CoIII–CoIV} redox process, we have investigated...
Despite the growing data supporting role of microcirculation in regulating liver function, little this knowledge has been translated into clinical practice. The aim study is to quantify hepatic vivo using sidestream dark field (SDF) imaging and correlate these findings with blood flow, hemodynamic parameters, soluble mediators. Postreperfusion was assessed SDF imaging. Hepatic measurements included functional sinusoidal density (cm/cm 2 ), diameter (μm), red cell velocity (μm/second),...
The ability to measure nuclear magnetic resonance (NMR) spectra with a large sample volume is crucial for concentration-limited biological samples attain adequate signal-to-noise (S/N) ratio. possibility 5-mm cryoprobe currently absent at the 1.2-GHz NMR instruments due exceedingly high radio frequency power demands, which four times compared 600-MHz instruments. Here, we overcome high-power demands by designing optimal control (OC) pulses up 20 lower requirements than necessary...
We aimed to describe the demand for liver transplantation (LTx) and patient outcomes on waiting list at Australian National Liver Transplantation Unit, Sydney over last 20 years.We performed a retrospective analysis with data divided into three eras: 1985-1993, 1994-2000 2001-2008.The number of patients accepted LTx increased from 320 372 548 (P < 0.001) being increasing 262 312 452 respectively 0.001). The median adult recipient age 45 48 52 years while it decreased in children 4 2 1 = In...
The piezoelectric sorption detection method is evaluated for use in construction of an inexpensive, rugged, compact, and fast sensor measuring the concentration inhalation anesthetics. 10 MHz quartz crystals were coated with various substances their frequency shifts measured upon exposure to varying concentrations halothane, enflurane, nitrous oxide. For a silicone rubber coating, response was found be linear concentration, sufficient signal allow resolution approximately 0.05 volume percent...
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study to investigate the potential relationship between postreperfusion gene expression, serum mediators, and onset AKI LT. Sixty-five consecutive patients undergoing LT were included in study. Reverse transcription polymerase chain reaction (PCR) was performed on biopsies. Gene expression 23 genes involved ischemia/reperfusion (IRI) evaluated....