A5060274786- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic floor disorders treatments
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Diverticular Disease and Complications
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Enhanced Recovery After Surgery
- Patient-Provider Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Palliative Care and End-of-Life Issues
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Stoma care and complications
- Frailty in Older Adults
- Pancreatic and Hepatic Oncology Research
Royal Prince Alfred Hospital
2016-2025
The University of Sydney
2016-2025
Cooperative Trials Group for Neuro-Oncology
2007-2024
Sydney Local Health District
2015-2024
Sunshine Coast University Hospital
2024
Centre for Rural and Remote Mental Health
2024
James Cook University
2024
Australian Institute of Tropical Health and Medicine
2024
Institute for Urban Indigenous Health
2024
Griffith University
2005-2024
Abnormalities in CD4+CD25+Foxp3+ regulatory T (T reg) cells have been implicated susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However, phenotypic functional assessment of human reg has hampered by difficulty distinguishing between CD25-expressing activated cells. Here, we show that expression CD127, the α chain interleukin-7 receptor, allows an unambiguous flow cytometry–based distinction be made CD127lo CD127hi conventional within CD25+CD45RO+RA−...
<h3>Importance</h3> Laparoscopic procedures are generally thought to have better outcomes than open procedures. Because of anatomical constraints, laparoscopic rectal resection may not be because limitations in performing an adequate cancer resection. <h3>Objective</h3> To determine whether is noninferior for adequacy clearance. <h3>Design, Setting, and Participants</h3> Randomized, noninferiority, phase 3 trial (Australasian Cancer the Rectum; ALaCaRT) conducted between March 2010 November...
To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer.Eligible patients had ultrasound- or magnetic resonance imaging-staged T3N0-2M0 adenocarcinoma within 12 cm from anal verge. SC consisted of pelvic 5 × Gy in 1 week, early surgery, six courses adjuvant chemotherapy. LC was 50.4 Gy, 1.8 Gy/fraction, 5.5 weeks, with continuous infusional fluorouracil 225 mg/m(2) per day, surgery 4 to 6 four chemotherapy.Three...
Laparoscopy has revolutionized many abdominal surgical procedures. Laparoscopic colectomy become increasingly popular. The short- and long-term benefits satisfactory oncological treatment of colorectal cancer by laparoscopic-assisted resection remain topical. outcomes all international randomized controlled trials are still awaited, short-term important in the interim.Between January 1998 April 2005, a multicenter, prospective, clinical trial patients with colon was conducted. Six hundred...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
The aim of the study was to determine efficacy laparoscopic rectal resection (Lap) versus open laparotomy and (Open) for cancer on locoregional recurrence (LRR) disease-free survival (DFS) at 2 years.Although a Lap approach colon surgery may offer similar oncological outcomes Open with potentially less morbidity, this remains be clearly established treatment cancer.A randomized, multicenter noninferiority phase 3 trial 475 patients T1 T3 adenocarcinoma <15 cm from anal verge, given or...
Abstract Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, the majority of data from single-centre series. This study analysed an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized on patients who had pelvic LRRC between 2004 and 2014 were accrued 27 specialist centres. The primary endpoint was survival. impact resection margin, bone resection, node status use...
Abstract Background The objectives of this study were to compare both subjective clinical outcomes and the objective stress response laparoscopic open abdominal rectopexy in patients with full-thickness rectal prolapse. Abdominal for prolapse is well suited a approach as no resection or anastomosis necessary. Methods Forty randomized before operation group an group. They agreed conform pathway (CP) liquid diet (CP1) full mobility (CP2) on day 1, solid (CP3) 2 discharge (CP4) 5. Their...
<h3>AIM</h3> Colorectal cancer has been described in association with hyperplastic polyposis but the mechanism underlying this observation is unknown. The aim of study was to characterise foci dysplasia developing polyps subjects on basis DNA microsatellite status and expression mismatch repair proteins hMLH1, hMSH2, hMSH6. <h3>MATERIALS AND METHODS</h3> material derived from four patients between one six synchronous colorectal cancers. Normal (four), (13), dysplastic malignant (11) samples...
Surgery for recurrent rectal cancer is the only therapy with curative potential. This study was designed to assess factors that affect survival after surgery locally cancer.Prospective databases of patients undergoing surgical resection at three tertiary centers between 1990 and 2006 were combined analyzed. Cox regression Kaplan-Meier analysis used associated survival.A total 160 (96 males) underwent (median age, 63 (range, 27-93) years). Ninety-five (59 percent) received neoadjuvant...
Although the randomized, controlled trial has gained preeminence as criterion standard for evaluating pharmaceutical treatments, randomized trials in surgery have been perceived difficult to surmount. Furthermore, attitudes of surgeons toward are not well understood. We determined views Australian about feasibility and barriers surgical trials.All members Section Colon Rectal Surgery Royal Australasian College Surgeons (n = 147) all colorectal subspecialist 72) were mailed a questionnaire...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
National cancer policies identify the improvement of care coordination as a priority to improve delivery health services for people with cancer. Identification current barriers effective is needed drive service improvement. A qualitative study was undertaken in which semi-structured individual interviews and focus groups were conducted those best placed issues; patients who had been treated range cancers their carers well professionals involved providing care. Data collection continued until...
This study examined what parents of children with disabilities and special needs found helpful about belonging to mutual support groups. Quantitative data (based on 56 from 6 groups) indicated that members the groups very were satisfied they received their groups; also described as high in cohesion, expressiveness, task orientation, self-discovery. A grounded theory analysis focus group 43 5 such was three broad domains: (1) sociopolitical, which involved developing a sense control agency...
In Brief Objective: We report a multicentered randomized controlled trial across Australia and New Zealand comparing laparoscopic-assisted colon resection (LCR) with open (OCR) for cancer. Background: Colon cancer is significant worldwide health issue. This investigated whether the short-term benefits associated LCR could be achieved safely, without survival disadvantages, in our region. Methods: A total of 601 patients potentially curable were to receive or OCR. Primary endpoints 5-year...
PURPOSE: Lateral pelvic recurrence is considered a poor prognostic variable and relative contraindication to surgery because of the difficulty in achieving clear margins. The aim this study was outline our surgical approach lateral sidewall involvement assess oncologic long-term outcomes. METHODS: A retrospective review prospective database performed. Patient demographics, cancer operative details, intent, margins, lymph node status, rerecurrence at resection site, follow-up, living death...