A5063992499- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Fermentation and Sensory Analysis
- Horticultural and Viticultural Research
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Wine Industry and Tourism
- Prenatal Substance Exposure Effects
- Hypothalamic control of reproductive hormones
- Neuroscience of respiration and sleep
- Electrolyte and hormonal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Plant Pathogens and Fungal Diseases
- Education and Critical Thinking Development
- Regulation of Appetite and Obesity
- Algal biology and biofuel production
University of Malaya
2023-2024
University of Auckland
2009-2024
Kennesaw State University
2021-2024
University of Georgia
2024
Korea Basic Science Institute
2021-2023
Korea University of Science and Technology
2019-2022
Keimyung University
2001-2020
Yanbian University Hospital
2020
Inje University Haeundae Paik Hospital
2020
CHA Bundang Medical Center
2020
Amyloids are highly organized protein aggregates that associated with both neurodegenerative diseases such as Alzheimer disease and benign functions like skin pigmentation. self-polymerize in a nucleation-dependent manner by recruiting their soluble protein/peptide counterpart stable against harsh physical, chemical, biochemical conditions. These extraordinary properties make amyloids attractive for applications nanotechnology. Here, we suggest the use of formulation long-acting drugs. It is...
There is increased need to identify sustainable agricultural methods which avoid environmental degradation. Previous studies have focused on the effect of specific interventions large organisms, but we fewer data evaluating how microbes, are key components ecosystems, might be affected. Additionally, previous been constrained as they only examined one habitat in an ecosystem and not gone evaluate approach harvested crops. Here take ecosystems net conventional versus biodynamic management by...
Testosterone (T) secretion is classically considered to be under the primary control of pituitary LH, itself regulated by hypothalamic peptide LH-releasing hormone. Secretagogues present in general circulation and/or manufactured testis can also alter Leydig cell activity independently pituitary. Finally, spanchnic innervation regulates testicular LH receptors and blood flow. In work, we provide evidence that, addition, there may a neural brain-testicular circuit that T release function...
The impact of juice press fractions upon the content varietal thiols in Sauvignon blanc has been examined for wines fermented at laboratory scale (750 mL). Wines made from pressed juices (taken 0.25 and 1.0 bar) contained less than half concentration 3-mercaptohexan-1-ol (3MH) 3-mercaptohexyl acetate (3MHA), important contributors to tropical passion fruit character wines, compared free run juices. exhibited lower acidity values, more rapid decline glutathione content, advanced polyphenol...
Recent studies indicate that the regulation of adrenocorticotropin (ACTH) secretion by corticotropin-release factor (CRF) is mediated predominantly type I CRF receptor (CRF-R1). Indeed, CRF-R1-deficient (CRF-R1 −/−) mice show marked impairment pituitary-adrenal axis. However, plasma ACTH concentrations unstressed CRF-R1 −/− are similar to those in wild-type mice. We here arginine vasopressin (AVP) a major secretagogue resting conditions, since administration anti-AVP serum, but not anti-CRF...
The commitment of cells to specific lineages during development is determined in large part by the relative expression various homeodomain (HOX) selector proteins, which mediate activation distinct genetic programs. But mechanisms individual HOX genes are themselves targeted for different cell types remain largely uncharacterized. Here, we demonstrate that STF-1, a protein functions pancreatic morphogenesis and glucose homeostasis encoded an “orphan” homeobox gene on mouse chromosome 5. When...
The peripheral injection of alcohol stimulates the activity hypothalamic-pituitary-adrenal (HPA) axis, but ready penetration this drug in most bodily compartments has made it difficult to identify its specific sites action. Here we determined whether can directly influence corticotropes. We first acted within brain stimulate neurons paraventricular nucleus (PVN) hypothalamus, which synthesizes corticotropin-releasing factor (CRF) and vasopressin (VP). To test hypothesis, injected...
Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin (PS) gene. This suggests that an altered function mutated PSs accounts for a fundamental process leading AD. Here we identify new PS binding protein, PBP, which is highly expressed in cerebral cortex and hippocampus. immunohistochemical studies cell fractionation analysis show PBP redistributes from cytoplasm membranes presence PS. In addition, deficient soluble fraction sporadic AD brains.
Immediate early gene (IEG) expression has been routinely used by neuroscientists as an index of neuronal activation. In the case hypothalamic–pituitary–adrenal axis, induction c- fos and/or NGFI-B mRNAs in parvocellular paraventricular nucleus (pPVN) documented after a variety stimuli that increase adrenocorticotropin (ACTH) systemic circulation. However, functional relationship between IEGs and transcription genes for ACTH secretagogues corticotropin-releasing factor (CRF) arginine...
Increases in circulating glucagon during fasting maintain glucose balance by stimulating hepatic gluconeogenesis. Acute ethanol intoxication promotes hypoglycemia through an increase NADH, which inhibits gluconeogenesis reducing the conversion of lactate to pyruvate. Here we show that acute exposure also lowers blood concentrations inhibiting CREB-mediated activation gluconeogenic program response glucagon. Ethanol blocked recruitment CREB and its coactivator CRTC2 promoters up-regulating...
Background: We have previously shown that long‐term alcohol treatment blunts the ACTH response to itself, as well other stresses, and is accompanied by decreased pituitary responsiveness vasopressin (VP), but not corticotropin‐releasing factor (CRF). The present work aims determine relevance of changes in CRF VP receptors gland and/or peptide stores neurons paraventricular nucleus (PVN) hypothalamus, areas are most directly involved release. Methods: Intact male rats were exposed using a new...