A5100340189- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Fractures and Fixation Techniques
- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Cardiac Arrhythmias and Treatments
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Alzheimer's disease research and treatments
- Respiratory Support and Mechanisms
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Orthopedic Surgery and Rehabilitation
- Innovations in Medical Education
- Kidney Stones and Urolithiasis Treatments
- Adipose Tissue and Metabolism
- Gastrointestinal disorders and treatments
- Cardiovascular Health and Disease Prevention
- Renal cell carcinoma treatment
- Elbow and Forearm Trauma Treatment
Chongqing Cancer Hospital
2017-2025
Chongqing University
2004-2025
Hangzhou Medical College
2021-2024
Taizhou Central Hospital
2020-2024
Taizhou University
2020-2024
Second Military Medical University
2016-2024
Chongqing Medical University
2010-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Fujian Normal University
2017-2024
Ningxia Medical University
2024
The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies optimizing stem-cell-based myocardial therapy are needed.The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) more effective than cultured under ambient oxygen levels the treatment injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation.MSCs were engineered...
<h3>Objective</h3> To evaluate the efficacy and tolerability of replacing tetracycline with amoxicillin in bismuth quadruple therapy. <h3>Design</h3> Subjects who were infected <i>Helicobacter pylori</i> naïve to treatment randomly (1:1) assigned receive a 14-day modified therapy: lansoprazole 30 mg, 1 g, potassium citrate 220 mg (elemental bismuth), twice day metronidazole 400 four times (metronidazole group) or clarithromycin 500 (clarithromycin group). Six weeks after treatment, <i>H....
Summary Background Increasing Helicobacter pylori resistance has led to decreases in treatment effectiveness. Aim To test the effectiveness of susceptibility‐guided therapy vs a locally highly effective empiric modified bismuth quadruple for first‐line H region with high antimicrobial . Methods We compared 14‐day using multicentre superiority‐design trial, which randomised infected subjects 3:1 (a) therapies contained esomeprazole 20 mg and amoxicillin 1 g b.d. plus clarithromycin 500 mg,...
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands single disease-specific targets. For Alzheimer's disease (AD), focus amyloid beta peptide (Aß) that mediates familial pathology. However, given age greatest risk factor AD, we explored an alternative scheme efficacy in multiple cell culture models of age-associated pathologies rather than exclusively metabolism. Using this approach, identified exceptionally potent, orally active,...
To compare the efficacy and safety of bismuth-containing quadruple therapy with tetracycline or amoxicillin for rescue treatment Helicobacter pylori.The study was a non-inferiority trial H. pylori eradication at least two previous failures. Subjects were randomized to receive 14-day b.i.d. lansoprazole 30 mg bismuth 220 mg, plus metronidazole 400 q.i.d 1 g t.i.d (amoxicillin group) 500 (tetracycline group). Antimicrobial susceptibility assessed by agar-dilution method. Primary outcome 6...
Investigation of pain requires measurements nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority gait analysis over traditional evaluations (e.g., skin sciatic function index [SFI]) in detecting subtle improvements deteriorations animal models. Here, parameters, whose criteria include (1) alteration models, (2) correlation with threshold, (3) normalization by analgesics, were identified representative models neuropathic (spared nerve injury:...
Left bundle branch area pacing (LBBAP) has developed in an effort to improve cardiac resynchronization therapy (CRT). We aimed compare the long-term clinical outcomes between LBBAP and biventricular (BIVP) patients with heart failure (HF) complete left block (CLBBB). Consecutive HF CLBBB requiring CRT received either or BIVP were recruited at Second Affiliated Hospital of Nanchang University from February 2018 May 2019. assessed their implant parameters, electrocardiogram (ECG), during...
BackgroundAblation has been recommended by worldwide guidelines as first-line treatment for hepatocellular carcinoma (HCC), while evidence regarding its efficacy primary intrahepatic cholangiocarcinoma (iCCA) is lacking. We aimed to study the of ablation in treating iCCA comparing prognosis with surgery.MethodsIn this real-world multicenter cohort from January 2009 June 2022, 10,441 patients ten tertiary hospitals were identified. Patients who underwent curative-intent microwave (MWA) or...
Most <em>Aloe</em> species are used as new food or functional ingredient. Even though widely known for its health benefits, the anti-inflammatory effects and underlying mechanisms of Aloin (Alo), an anthraquinone compound isolated from plant genus <em>Aloe</em>, remain unidentified. Here, we investigated protective Alo against cecal ligation puncture (CLP)-induced sepsis microflora in mice. significantly improved CLP-induced survival rate septic mice, downregulated expression proinflammatory...
Abstract Background Helicobacter pylori ( H. ) eradication has become increasingly difficult especially for penicillin allergy patients. Aims To evaluate the efficacy of adding bismuth or high‐dose metronidazole to an regimen containing a proton‐pump inhibitor, clarithromycin, and in patients allergic penicillin. Methods Pilot study which penicillin‐allergic, treatment‐naive subjects were randomized (1:1) 14‐day esomeprazole (20 mg q12h), clarithromycin (500 high dose (400 q6h) with BECM...
Benzo [a] pyrene (BaP), a potent carcinogen, has been proved that it toxicological effects via activation the aryl hydrocarbon receptor (AhR) pathway. AhR can participate in regulating lipogenesis and lipolysis. This topic will verify whether BaP regulates lipid metabolism AhR.
Nicotine reduces beta-amyloidosis and has a beneficial effect against Alzheimer's disease (AD), but the underlying mechanism is not clear. The abnormal interactions of beta-amyloid (Abeta) with metal ions such as copper zinc are implicated in process Abeta deposition AD brains. In present study, we investigated nicotine on homeostasis hippocampus cortex APP(V717I) (London mutant form APP) transgenic mice. A significant reduction contents senile plaques neuropil observed after treatment....
To test the efficacy of lansoprazole, bismuth, levofloxacin, and amoxicillin therapy compared to bismuth metronidazole tetracycline (BMT) quadruple for second-line treatment Helicobacter pylori infection.A total 284 patients who failed prior H. eradication were randomized receive 14-day regimens containing lansoprazole 30 mg twice a day (b.i.d.), subcitrate 240 b.i.d., either amoxcillin, 1 g b.i.d. levofloxacin 500 once daily (qd) (levofloxacin/bismuth therapy) or 400 four times (q.i.d.)...
Background: The beneficial properties of tea polyphenols have been extensively studied; however, less attention has paid to their effects, especially anti-inflammatory effect during exhaustive exercise. Objective: present study assessed the potential protective effects against fatigue, inflammation and tissue injury caused by an exercise bout in rats. Design: Twenty-four healthy male rats were divided into three groups. Group C was a sedentary control group, Groups E+TP E performed single...
Since July 2015, vesicular lesions affecting growing pigs and sows accompanied with neonatal mortality have been reported in multiple U.S. states. Senecavirus A has consistently detected from these cases. The complete genome sequences of 3 recent isolates were determined to further characterize this virus.