A5074471116- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Distributed and Parallel Computing Systems
- Vehicle Routing Optimization Methods
- Optimization and Packing Problems
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Semantic Web and Ontologies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- S100 Proteins and Annexins
- Service-Oriented Architecture and Web Services
- Advanced Manufacturing and Logistics Optimization
- Trauma Management and Diagnosis
- Scientific Computing and Data Management
- Smart Parking Systems Research
- Ultrasound in Clinical Applications
- Supply Chain and Inventory Management
- Intensive Care Unit Cognitive Disorders
- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
Second Affiliated Hospital of Zhejiang University
2017-2025
Key Laboratory of Guangdong Province
2021-2024
Zhejiang University
2003-2023
Nielsen (United States)
2021
Ningbo University
2013-2020
Weil Institute of Critical Care Medicine
2012-2014
Foundation for the Advancement in Research in Medicine
2012-2014
Society of Critical Care Medicine
2012
Xuzhou Medical College
2008
Imperial College London
2007
Treatment of cardiac arrest/cardiopulmonary resuscitation (CA/CPR)-induced brain injury remains a challenging issue without viable therapeutic options. Octanoic acid (OA), lipid oil that is mainly metabolized in the astrocytes brain, promising treatment for this type owing to its potential functions against oxidative stress, apoptosis, inflammation, and ability stabilize mitochondria. However, application OA strictly limited by short half-life low available concentration target organ....
We develop a new local search approach based on network flow model that is used to simultaneously evaluate several customer ejection and insertion moves. use this direct swap procedure solve the well-known Vehicle Routing Problem. The capacity constraints are relaxed using penalty terms whose parameter values adjusted according time feedback. Tabu Search incorporated into overcome optimality. More advanced issues such as intensification diversification strategies developed provide effective...
Considers an airport gate assignment problem that dynamically assigns gates to scheduled flights based on passengers' daily origin and destination flow data. The objective of the is minimize overall connection times during which passengers walk catch their flights. We formulate this as a mixed 0-1 quadratic integer programming then reformulate it with linear function constraints. design simple tabu search meta-heuristic solve problem. algorithm exploits special properties different types...
Following cardiopulmonary resuscitation (CPR), the ensuing cardiac and cerebral injuries contribute to poor outcome of arrest (CA) victims, in which pathogenetic process is possibly driven by cell pyroptosis ferroptosis. Mesenchymal stem cells (MSCs) have been shown be a promising strategy for post-resuscitation protection rat, but its effectiveness clinically relevant swine model potential protective mechanism remain unknown. The present study was designed investigate whether MSCs...
<title>Abstract</title> Background Inflammation plays a critical role in the pathogenesis of limb injury caused by Deinagkistrodon acutus snakebite. Investigating its regulatory mechanisms and intervention strategies may uncover effective therapeutic approaches for this condition. Recent studies have identified pyroptosis as key pathway exacerbating target organ damage amplifying inflammatory responses. Immune Matrix-Regulatory Cells (IMRC), novel type mesenchymal stem cell, their derived...
To investigate the mechanism of human embryonic stem cell-derived mesenchymal cells (hESC-MSC) in alleviating brain injury after resuscitation swine with cardiac arrest (CA). Twenty-nine healthy male large white were randomly divided into Sham group (n = 9), cardiopulmonary (CPR) 10) and hESC-MSC 10). The only completed animal preparation. In CPR group, model CA-CPR was established by inducing ventricular fibrillation for 10 minutes electrical stimulation 6 minutes. At 5 successful...
Brain injury is a common sequela following cardiac arrest (CA), with up to 70% of hospitalized patients dying from it. microvascular endothelial cells (BMVECs) play crucial role in post-cardiac brain (PCABI). However, the effects and mechanisms targeting BMVEC energy metabolism mitigate remain unclear. We established mouse model by injecting potassium chloride into right internal jugular vein. Mass spectrometry detected targeted changes short-chain fatty acids metabolites CA/CPR group...
Tabu Search is a metaheuristic that has proven to be very effective for solving various types of combinatorial optimization problems. To achieve the best results with tabu search algorithm, significant benefits can sometimes gained by determining preferred values certain parameters such as tenures, move selection probabilities, timing and structure elite solution recovery intensification, etc. In this paper, we present implement some new ideas fine‐tuning algorithm using statistical tests....
Severe hemorrhagic shock and resuscitation is a state of global body ischemia reperfusion that causes myocardial cerebral dysfunction. We investigated whether remote ischemic preconditioning (RIPC) would reduce injuries after as the result K(ATP) channel activation. Twenty-one male rats were randomized into three groups: RIPC, RIPC with blocker, control. Remote was induced by four cycles 5 min limb followed for min. Hemorrhagic removing 50% estimated total blood volume during an interval 1...
We develop a generic tabu search heuristic for solving the well-known vehicle routing problem. This algorithm explores advantages of simple local and improvement heuristics as well complex meta-heuristic. The solutions generated by these are selected assembled set-partitioning model to produce superior solutions. Computational experience on standard benchmark problems is discussed comparisons with other up-to-date methods provided.
To avoid aggressive fluid resuscitation during hemorrhagic shock, is best guided by a specific measurement of tissue perfusion. We investigated whether sublingual PCO2 would reduce the amount without compromising outcomes shock. Ten male domestic pigs weighing between 34 and 37 kg were used. Forty-five percent estimated blood volume was removed an interval 1 h. The animals then randomized to receive based on either or pressure (BP). In PCO2-guided group, initiated when exceeded 70 Torr...
Cardiac arrest and resuscitation are models of whole body ischemia reperfusion injury. Postresuscitation myocardial cerebral dysfunction major causes high mortality morbidity. Remote ischemic postconditioning has been proven to provide potent protection the heart brain against In this study, we investigated effects remote on postresuscitation function in a rat model cardiac resuscitation.Prospective, randomized, controlled experimental study.University-affiliated animal research...
One of the private line network design problems in telecommunications industry is to interconnect a set customer locations through ring end offices so as minimize total tariff cost and provide reliability. We develop Tabu Search method for problem that incorporates long term memory, probabilistic move selections, hierarchical evaluation, candidate list strategies an elite solution recovery strategy. Computational results test data show heuristic finds optimal solutions all can be solved...
A complex allocation-routing problem arising in grocery distribution is described. It solved by means of a heuristic that alternates between these two components. Tests on real and artificial data confirm the efficiency robustness proposed approach.
Post-cardiac arrest syndrome, which has no specific curative treatment, contributes to the high mortality rate of victims who suffer traumatic cardiac (TCA) and initially can be resuscitated. In present study, we investigated potential ulinastatin mitigate multiple organ injury after resuscitation in a swine TCA model. Twenty-one male pigs were subjected hemodynamic shock (40% estimated blood loss 20 min) followed by (electrically induced ventricular fibrillation) respiratory suspension for...