A5101419039- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiovascular and exercise physiology
- Cardiac and Coronary Surgery Techniques
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Oral microbiology and periodontitis research
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease and Transplantation
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Safe Handling of Antineoplastic Drugs
Bryn Mawr Hospital
2003-2023
Main Line Health
2003-2023
Imperial Consultants
2023
Cambridge University Hospitals NHS Foundation Trust
2023
University of Cambridge
2023
Pinnacle Clinical Research
2022
Bryn Mawr College
2000-2021
Centre Hospitalier d'Arras
2017
The University of Texas Health Science Center at San Antonio
2001-2016
Thomas Jefferson University
2000-2015
Inflammatory mediators that originate in vascular and extravascular tissues promote coronary lesion formation. Adipose tissue may function as an endocrine organ contributes to inflammatory burden patients at risk of cardiovascular complications. In this study, we sought compare expression epicardial subcutaneous adipose stores with critical CAD.Paired samples were harvested the outset elective CABG surgery (n=42; age 65+/-10 years). Local chemokine (monocyte chemotactic protein [MCP]-1)...
The maximal exercise capacity of patients with chronic heart failure is frequently reduced. To investigate whether this intolerance caused by inadequate nutritive flow to skeletal muscle, we compared cardiac outputs, leg blood flow, and metabolism during bicycle in seven normal oxygen uptake (VO2) (greater than 20 ml/min/kg; group A), eight moderately reduced VO2 (15 18 B), markedly (less 14 C). As the severity increased from A C there was a progressive decline output at any given workload...
Multiple pathways contribute to accelerated coronary atherosclerosis in diabetics, including increased oxidative stress and inflammatory burden. Accordingly, the mechanisms of abnormal formation reactive oxygen species changes gene expression were examined diabetic arteries.In pigs with streptozotocin-induced diabetes, superoxide was augmented media adventitia because NAD(P)H oxidase activity (3 months) accompanied by upregulated its cytosolic subunit, p22phox. Diabetes-induced resulted...
Background— Myocardial salvage is often suboptimal after percutaneous coronary intervention in ST-segment elevation myocardial infarction. Posthoc subgroup analysis from a previous trial (AMIHOT I) suggested that intracoronary delivery of supersaturated oxygen (SSO 2 ) may reduce infarct size patients with large infarction treated early. Methods and Results— A prospective, multicenter was performed which 301 anterior undergoing within 6 hours symptom onset were randomized to 90-minute SSO...
Abstract Objective: This prospective randomized trial compared the Angio‐Seal VIP™ with Perclose Proglide™ and to manual compression respect time hemostasis ambulation, patient satisfaction, vascular complications following percutaneous coronary intervention (PCI). Background: The use of arterial closure devices for reduction PCI remains controversial. There have been no head trials comparing these most commonly used PCI. Methods: Two hundred patients undergoing were compression, or VIP™....
The aerobic exercise capacity of patients with chronic heart failure is frequently impaired because inadequate O2 transport to working skeletal muscle. To determine whether hydralazine improves muscle, we examined the effect intravenous on blood flow (measured by thermodilution) and metabolism in leg during maximal upright bicycle 10 failure. Hydralazine increased cardiac output (5.6 +/- 0.7 6.7 0.6 l/min; p less than .01) decreased systemic extraction (79 3% 65 2%; but did not alter uptake...
Aortic input impedance and hydraulic power were derived from simultaneous catheter recordings of ascending aortic pressure velocity in eight normal subjects 11 age-matched with clinical heart failure secondary to idiopathic congestive cardiomyopathy. Resting data revealed the characteristic depression cardiac output elevation systemic vascular resistance patients failure. The pulsatile component load, (Zc), was similar both groups (Zc normal: 85 +/- 30 dyne-sec-cm-5; Zc cardiomyopathy: 93 33...
Abstract The objective of this study was to evaluate the pharmacokinetic response intravenous (IV) enoxaparin given 8–12 hr after subcutaneous (SC) dosing in patients undergoing percutaneous coronary intervention (PCI). Fifty‐five received SC (1 mg/kg every 12 hr) followed by an IV bolus (0.3 mg/kg) last dose, at start PCI or during catheterization. Anti‐Xa levels were within target range 98% 2–8 96% following bolus, and 91% for a further 2 hr. Subcutaneous provides sufficient anti‐Xa dose....
Background —Recent findings suggesting the involvement of adventitial cells in coronary repair have raised questions regarding phenotypic “plasticity” medial smooth muscle (SMCs). Accordingly, aims present study were to examine characteristics and compare responses noncoronary SMCs stimulation. Methods Results —Enzymatically isolated (human porcine) distinct from SMCs, showing poor adhesion spreading, as well lower proliferation, collagen synthesis, LDL degradation. Several extracellular...
Background —Enoxaparin inhibits smooth muscle cell proliferation in experimental models. Intimal hyperplasia has been found to be the principal cause of restenosis after coronary stent implantation. We sought determine whether intramural delivery enoxaparin before stenting de novo lesions decreases restenosis. Methods and Results —One hundred patients who were undergoing randomly assigned either local administration during predilation with reduced systemic heparinization or standard,...