A5000396863- Genetic factors in colorectal cancer
- COVID-19 and healthcare impacts
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Trauma and Emergency Care Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- 3D Printing in Biomedical Research
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal vascular conditions and treatments
- Appendicitis Diagnosis and Management
- Microfluidic and Bio-sensing Technologies
- Colorectal Cancer Surgical Treatments
- Global Health Workforce Issues
- Bone Tissue Engineering Materials
- Abdominal Trauma and Injuries
- Mitochondrial Function and Pathology
- Congenital Anomalies and Fetal Surgery
- Genetic Neurodegenerative Diseases
- Colorectal and Anal Carcinomas
- Nuclear Receptors and Signaling
- Inflammatory Biomarkers in Disease Prognosis
- Radiation Dose and Imaging
- Machine Learning in Materials Science
Umeå University
2017-2024
Bielefeld University
2023-2024
Centre for Research and Technology Hellas
2020-2023
Cambridge University Hospitals NHS Foundation Trust
2023
Aristotle University of Thessaloniki
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by the expansion of polyglutamine (polyQ) tract in ATXN1 protein. This thought to be responsible for gradual aggregation mutant protein, which associated with increased cytotoxicity and neuronal cell death. Apart from polyQ tract, other domains are also involved initial events protein such as dimerization domain that promotes oligomerization. interacts various proteins; among them, MED15 significantly enhances...
Abstract Background Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly patients with right-sided tumors. On the other hand, defective mismatch repair (dMMR) tumors, primarily located right colon, are known to have favorable survival and dense local immune infiltration. The aim of this study was see if there is any form relationship between these seemingly diverse entities. Methods Complete...
Plant cells are omnipotent and breeding of new varieties can be achieved by protoplast fusion. Such fusions treatment with poly(ethylene glycol) or applying an electric field. Microfluidic devices allow for controlled conditions targeted manipulation small batches down to single-cell analysis. To provide achieve high reproducibility, we developed characterized a microfluidic device reliably trap some Arabidopsis thaliana protoplasts induced cell fusion addition (PEG, molecular weight 6000)....
Background: Biocompatible materials-topography could be used for the construction of scaffolds allowing three-dimensional (3D) organization human stem cells into functional tissue-like structures with a defined architecture. Methods: Structural characterization an alumina-based substrate was performed through XRD, Brunauer–Emmett–Teller (BET) analysis, scanning electron microscopy (SEM), and wettability measurements. Biocompatibility assessed by measuring proliferation differentiation neural...
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in the ATXN1 gene. It characterized presence of polyglutamine (polyQ) intranuclear inclusion bodies (IIBs) within affected neurons. In order to investigate impact polyQ IIBs SCA1 pathogenesis, we generated novel protein aggregation model inducible overexpression mutant ATXN1(Q82) isoform human neuroblastoma SH-SY5Y cells. Moreover, developed simple and...
Stage II colon cancer is primarily a surgical disease. Only still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship between chemotherapy and survival after relapse furthermore definitely explored in this group patients. A number reports suggest some association defective mismatch repair (dMMR) colorectal stage prognosis, but due to contradictory results existing studies, the exact predictive role fully understood.Retrospective...
Abstract The systemic inflammatory response (SIR), defined as elevated levels of circulating C-reactive protein (CRP), is an important predictor impaired survival in colorectal cancer. aim this study was to explore the prognostic role SIR and its association with tumour mismatch repair status immune response. Immune activity profiles mononuclear cells isolated from CRC tissues blood U-CAN exploration cohort ( n = 69), were analysed by flow cytometry. In validation 257), T-helper (T-bet + ),...
Abstract Background and Objectives Disparities between tumors arising via different sporadic carcinogenetic pathways have not been studied systematically. This retrospective multicenter cohort study evaluated the differences in risk for non‐colorectal malignancy colorectal cancer (CRC) patients from DNA mismatch repair status. Methods A European including total of 1706 CRC treated 1996 2019 three countries. The proficiency (pMMR) or deficiency (dMMR) was determined by immunohistochemistry....
Abstract Introduction The optimal timing of surgery for acute cholecystitis has been subject debate, but the predominant view supports early cholecystectomy. This study investigates safety cholecystectomy during weekends compared to delaying until weekdays. Method A population-based cohort based on data from GallRiks (Swedish National Register Gallstone Surgery and Endoscopic Retrograde Cholangiopancreateatography). Data cholecystectomies 2006-2020 were analysed. Patients operated with...
The latest developments in tissue engineering scaffolds have sparked a growing interest the creation of controlled 3D cellular structures that emulate intricate biophysical and biochemical elements found within versatile vivo microenvironments. objective this study was to 3D-print monolithic silica scaffold specifically designed for cultivation neural precursor cells. Initially, preliminary investigation conducted identify critical parameters pertaining calcination. This aimed produce sturdy...
Plant cells are omnipotent and breeding of new varieties can be achieved by protoplast fusion. Such fusions treatment with poly(ethylene glycol) or applying an electric field. Microfluidic devices allow for controlled conditions targeted manipulation small batches down to single cell analysis. To provide achieve high reproducibility, we developed characterized a microfluidic device reliably trap few Arabidopsis thaliana protoplasts induced fusion addition (PEG, molecular weight 6000)....
Intraoperative rendezvous endoscopic retrograde cholangiopancreatography (ERCP) is one of the single-stage options available for managing common bile duct stones during laparoscopic cholecystectomy [1]. The procedure allows immediate biliary cannulation and reduces risk post-ERCP pancreatitis [1] [2]. We report a case omentum stomach strangulation caused by trans-cystic guidewire routine ERCP, an unusual complication.
Drug discovery involves extremely costly and time consuming procedures can be significantly benefited by computational approaches, such as virtual screening (VS). Structure-based VS relies on scoring functions which aim to evaluate the binding of a candidate compound (ligand) protein target. Over last few years, advancement deep learning field has led development novel based convolutional neural networks (CNN), have achieved state-of-the-art results. In this paper, we present an integrated...
The primary therapy for biliary atresia is a surgical hepatic portoenterostomy, known as Kasai procedure, which has been shown to reduce mortality. Patients that undergo this procedure often develop complications such ascending cholangitis and cirrhosis. In case of recurrent cholangitis, revision percutaneous drainage are the most used techniques, while in rare cases endoscopic retrograde cholangiopancreatography (ERCP) used. Here we report patient with intrahepatic lithiasis secondary...