A5038182224- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Gallbladder and Bile Duct Disorders
- Social and Educational Sciences
- Glycosylation and Glycoproteins Research
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Molecular Biology Techniques and Applications
- Angiogenesis and VEGF in Cancer
- AI in cancer detection
- Global Health Workforce Issues
- Appendicitis Diagnosis and Management
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Proteoglycans and glycosaminoglycans research
Umeå University
2012-2024
GZA Ziekenhuizen Campus Sint-Augustinus
2021
Centre International de Recherche sur le Cancer
2016
National Institute for Public Health and the Environment
2016
Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs two rarer HGPs. The are defined owing to interface between cancer cells adjacent normal liver parenchyma that is in each pattern can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. current study provides consensus guidelines for scoring these Guidelines defining were established by a large international team. To assess...
Background Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) suggested to be at lower risk cardiovascular disease than their unhealthy (hyperinsulinaemic) counterparts. Whether similarly variable relationships exist for defined phenotypes cancer unknown. Methods Findings The association was investigated in...
Abstract Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved various metabolic, inflammatory immune‐related processes. The liver the primary site of synthesis. Liver dysfunction microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate metabolism increasing concentration BAs. Observations from prospective cohorts sparse. We conducted a study (233 HCC case‐control pairs) nested...
A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, hyperglycemia. It has been suggested that these processes stimulate the production toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes a group compounds known glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote cancer through their proinflammatory...
Abstract No reliable, non-invasive biomarker of metastatic breast cancer (mBC) exists: circulating CA15-3 (cCA15-3) is the marker mostly used to monitor mBC. Circulating collagen IV (cCOLIV) has been evaluated in other cancers and found be a promising biomarker. The overarching aim this study was evaluate cCOLIV as potential patients with first determine levels cCOL cCA15-3 healthy controls, primary (pBC) second compare different sites BC. third investigate prognostic value for mBC patients....
Background: Pancreatic ductal adenocarcinoma (pancreatic cancer) is often detected at late stages resulting in poor overall survival.To improve survival, more patients need to be diagnosed early when curative surgery feasible.We aimed identify circulating metabolites that could used as pancreatic cancer biomarkers.Methods: We performed metabolomics by liquid and gas chromatography-mass spectrometry plasma samples from 82 future matched healthy controls within the Northern Sweden Health...
Objectives: The aim of this research was to study whether plasma microRNAs (miRNA) can be used for early detection pancreatic cancer (PC) by analyzing prediagnostic samples collected before a PC diagnosis. Background: has poor prognosis due late presenting symptoms and metastasis. Circulating miRNAs are altered in at diagnosis but have not been evaluated setting. Methods: We first performed an initial screen using panel 372 retrospective case-control cohort that included early-stage patients...
Carcinoembryonic antigen (CEA) is the best circulating tumour marker for colorectal liver metastasis (CLM) but has suboptimal sensitivity and specificity. Circulating type IV collagen (COLIV) a new potential CLM marker. Here, COLIV CEA were measured in patients with resectable CLM. levels also related to of The prognostic value these markers on survival was evaluated. Preoperative plasma samples (n = 94) from 85) undergoing resection used. Seven underwent repeated resection. Samples 118...
Fetuin-A, also referred to as α2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known inhibit insulin actions. Hyperinsulinemia possible risk factor for colorectal cancer; however, the role of fetuin-A in development cancer unclear. We investigated association between circulating and nested case–control study within European Prospective Investigation into Cancer Nutrition. Fetuin-A concentrations were measured prediagnostic plasma samples from 1,367 cases matched controls. In...
Gallstones, a common gastrointestinal condition, can lead to several digestive complications and result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking physical inactivity, all of which are known risk colorectal cancer (CRC), as is However, it unclear whether factor CRC. We examined the association between history CRC European Prospective Investigation into Cancer Nutrition (EPIC) study, prospective cohort over half million participants from ten countries....
Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present elevated levels of COL in both CLM tissue and circulation. This study aimed to establish the cellular origin analyze circulating patients. The source was established through situ hybridization, immunohistochemical staining, morphological evaluation. Cellular expression vitro assessed by immunofluorescence. Tissue IV-degrading matrix metalloproteinases (MMPs)-2, -7,...
Introduction: Hereditary transthyretin amyloidosis (ATTR) is a genetic disease caused by point mutation in the TTR gene that causes liver to produce an unstable protein. The most effective treatment has been transplantation order replace variant producing with one produces only wild-type TTR. ATTR patients' livers are reused for sick patients, i.e. Domino procedure. However, recent findings have demonstrated can develop recipients within 7–8 years. aim of this study was elucidate how profile...
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death that typically presents at an advanced stage. No reliable markers for early detection presently exist. The prominent tumor stroma represents source circulating biomarkers use together with cell-derived earlier PDAC diagnosis. CA19-9 and CEA (cancer biomarkers), endostatin collagen IV (stroma-derived) were examined alone, or together, by multivariable modelling, using pre-diagnostic plasma samples (n = 259 samples) from...
We describe the fibrotic rim formed in desmoplastic histopathologic growth pattern (DHGP) of colorectal cancer liver metastasis (CLM) using situ sequencing (ISS). The origin is still a matter debate, and detailed cellular organization has not yet been fully elucidated. Understanding biology DHGP CLM can lead to targeted treatment improve survival.
Early detection of pancreatic ductal adenocarcinoma (PDAC) is challenging, and late diagnosis partly explains the low 5-year survival. Novel sensitive biomarkers are needed to enable early PDAC improve patient outcomes. Tissue polypeptide specific antigen (TPS) has been studied as a biomarker in diagnostics, it previously shown reflect clinical status better than 'golden standard' carbohydrate 19-9 (CA 19-9) that most widely used setting. In this cross-sectional case-control study using...
Purpose: Resectability assessment of patients with colorectal liver metastases is based on computed tomography and magnetic resonance imaging. Addition fluorine-18-fluorodeoxyglucose positron emission tomography/computed has been recommended, but the impact added information remains unclear. The primary aim this study was to determine how preoperative changed management in potentially resectable metastases. secondary investigate whether findings correlated metastatic disease cases extended...